Guest guest Posted December 30, 2004 Report Share Posted December 30, 2004 Chronic Fatigue Syndrome (EBV) JoAnn Guest Dec 29, 2004 16:26 PST ==================================================================== Chronic Fatigue Syndrome (EBV) Researchers are only beginning to target possible causes of CFS. Many suspect that it is caused by thyroid, adrenal, liver, or immune system dysfunction. It is a poorly understood disease involving many body systems. No single cause for chronic fatigue syndrome (CFS) has been identified. Therefore, it is defined by symptoms and by ruling out other known causes of fatigue. Suggested causes include chronic viral infections, food allergy, adrenal gland dysfunction, and many others. Another theory is that CFS is caused by a virus similar to the herpes virus, i.e. Epstein-Barr virus. The current definition is disabling fatigue lasting more than six months that reduces activity by more than half. When there is extreme muscle soreness, fibromyalgia may be the actual problem. Although CFS is considered a modern diagnosis, it may have existed for centuries under other names, such as " the vapors, " neurasthenia, " effort syndrome " (diagnosed in World War I veterans), hypoglycemia, and 'chronic 'mononucleosis. What are the symptoms of chronic fatigue syndrome? In addition to fatigue, there may also be muscle pain, joint pain not associated with redness or swelling, short-term memory loss, and an inability to concentrate. Some people with chronic fatigue syndrome also experience difficulty sleeping, swollen lymph nodes, and/or mild fever. How is it treated? Since there is no definitive conventional therapy for CFS, doctors use a combination of lifestyle changes, including aerobic exercise, healthful diet and stress reduction. Dietary changes that may be helpful: Some believe that people with CFS who have low blood pressure should not restrict their salt intake. Among CFS sufferers who have a form of low blood pressure triggered by changes in position (orthostatic hypotension), some have been reported in a preliminary study to be helped by dietary intervention and the addition of *sea* salt to their regimen. http://dowsers.com/page47.html People with CFS considering increasing salt intake should have their blood pressure monitored before making such a change. Nutritional supplements that may be helpful: The combination of potassium aspartate and magnesium aspartate has shown benefits for chronically fatigued people in double-blind trials. Usually 1 gram of aspartates is taken twice per day, and results have been reported within one to two weeks. Vitamin B12 deficiency may cause fatigue. Some reports even double-blind ones, have shown that people who are not deficient in B12 have 'increased energy' following a series of vitamin B12 injections. In one preliminary trial, 2,500 to 5,000 mcg of vitamin B12 given by injection every two to three days led to improvement in 50 to 80% of a group of people with CFS; most improvement appeared after several weeks of B12 shots. Oral or sublingual B12 supplements are unlikely to obtain the same results as injectable B12, because the body's ability to absorb large amounts is relatively poor. A preliminary trial has shown that people with CFS have reduced *functional* B-vitamin status when compared to people without the condition. The functional vitamin deficiency seen in this study was most pronounced for vitamin B6. L-carnitine is required for energy production in the powerhouses of cells (the mitochondria). There may be a problem in the " mitochondria " in people with CFS. Deficiency of L-carnitine has been seen in some CFS sufferers. One gram of carnitine taken three times daily for eight weeks led to improvement in CFS symptoms in one preliminary trial. NADH (nicotinamide adenine dinucleotide) helps make ATP, the energy source the body runs on. In a double-blind trial, people with CFS received 10 mg of NADH or a placebo each day for four weeks. Of those receiving NADH, 31% reported improvements in fatigue, decreases in other symptoms, and improved overall quality of life, compared with only 8% of those in the placebo group. Herbs that may be helpful: Some research suggests that CFS may be partially due to low *adrenal* function resulting from different " stressors " (e.g., mental stress, physical stress, and even viral illness) and impacting the normal " communication " between the hypothalamus, pituitary gland, and the adrenal glands. Licorice root is known to " stimulate " the adrenal glands and to block the breakdown of active cortisol in the body. One case report described a man with CFS whose symptoms improved after taking 2.5 grams of licorice root daily. While there have been no controlled trials to test licorice in patients with CFS, it may be worth a trial of six to eight weeks using 2 to 3 grams of licorice root daily. Other integrative approaches that may be helpful: Diet can play an important role in CFS treatment. Patients often discover that simply by modifying their diet, they can greatly improve their CFS symptoms. By choosing organically grown nutrient-rich foods which are easily digested, CFS patients can begin to take control. Good dietary choices include: Organic vegetables, fruits, Legumes, lentils, dried beans, whole organic grains, raw nuts, seeds and cold-water Fish such as Alaskan Salmon and Sardines (water-packed). CFS patients may also find that certain other foods *intensify* their symptoms. *Processed* foods, refined oils and foods that require more 'energy' to digest may 'increase' fatigue " symptoms " in CFS patients. Some foods that CFS patients may want to avoid include: Dairy products, Red meats and poultry, Alcohol, Refined Sugar, refined oils, fried food, and processed foods (margarines, snacks, breads,and baked goods containing Hydrogenated fats and oils. Caffeinated beverages, regular and diet sodas, coffee (both caffeinated and decaf), and chocolate may be problematic as well. The most debilitating symptom of CFS is a complete lack of energy. Some herbs used for 'energy enhancement' include: Fresh Ginger root Coconut Milk Licorice Root Dandelion Root & Leaf Alfalfa Organic Blackstrap Molasses Stinging Nettle tea (for iron) Garlic Chives -Fresh garlic Pineapple In a study at the University of California Department of Medicine, Echinacea, Olive leaf and Astragalus extracts enhanced cellular immune function in both healthy individuals and patients with depressed immune systems. Herbs that are recognized for immune system 'enhancement' include: Shitake Mushrooms Fresh Garlic Leeks, Onions, & Scallions Reishi Mushroom Olive leaf extract COq10 IMPORTANT SUPPLEMENTS: Dietary supplements can provide great relief to individuals suffering from CFS. In a study of fibromyalgia and CFS, patients reported a " significant improvement " in symptoms after taking nutritional supplements.Experts recommend the following nutritional supplements for CFS patients. Magnesium aspartate- is important for energy production, protein formation, and cellular replication. Most Americans are deficient in this mineral. Iron deficiency can lead to chronic fatigue and anemia. Spinach, kale, dandelion greens, beets, chives, dandelion greens, asparagus and organic eggs are important food sources. Vitamin B-complex consists of 11 B vitamins, including folic acid, vitamin B6, and vitamin B12. Vitamin B6 deficiency has been implicated in Epstein Barr, resulting in fatigue and anemia. Vitamin B12 deficiency is implicated in elevated *homocysteine* levels. High levels of homocysteine are believed to contribute blocked arteries leading to heart disease, the number one killer in the U.S. Elevated levels of *homocysteine* are characteristic of CFS patients. Researchers have discovered that CFS patients have lower levels of B vitamins than healthy patients. Vitamin E--an important antioxidant, protects cells against damage from toxins. It can enhance imune function and has antihistamine properties. Potassium deficiency has been linked to fatigue and muscle weakness. Potassium may help restore energy levels in CFS patients. *Pantothenic Acid*- helps your body 'make' its own *thyroid glandular*. Organic Blackstrap molasses, Brewers Yeast, Coconut milk and fresh Pineapple are rich in *Pantothenic Acid*. Vitamin C- is an important antioxidant known to support immune function. Under stressful conditions, the body needs additional vitamin C to help the immune system function normally. Vitamin C promotes healthy *adrenal* function, which is especially helpful for women who suffer from CFS and stress. In a study of 411 married couples, researchers found a clear correlation between chronic fatigue and low levels of vitamin C. Stress Reduction: Most experts agree that *stress* plays a part in CFS. Meditation induces relaxation. Affirmative thoughts are beneficial. Visualization may be combined with calming music to reduce stress Focus on positive imagery. Yoga can improve circulation and may increase energy Massage can also improve circulation and reduce stress as well. CFS Symptoms For many people, CFS begins after a bout with a cold, bronchitis, hepatitis, or an intestinal bug. For some, it follows a bout of infectious mononucleosis, or mono, which temporarily saps the energy of many teenagers and young adults. Often, people say that their illnesses started during a period of high stress. In others, CFS develops more gradually, with no clear illness or other event starting it. Unlike flu symptoms, which usually go away in a few days or weeks, CFS symptoms either hang on or come and go frequently for more than six months. CFS symptoms include: Intense Headache Tender lymph nodes Fatigue and weakness Muscle and joint aches Inability to concentrate What Causes CFS? While no one knows what causes CFS, for more than a century, doctors have reported seeing illnesses similar to it. In the l860s, Dr. George Beard named the syndrome " neurasthenia " because he thought it was a nervous disorder with weakness and fatigue. Since then, health experts have suggested other explanations for this baffling illness. Iron-poor blood (anemia) Low blood sugar (hypoglycemia) Environmental allergy A body wide yeast infection (candidiasis) In the mid-1980s, the illness became labeled " chronic EBV " when laboratory clues led scientists to wonder whether the Epstein-Barr virus (EBV) might be causing this group of symptoms. New evidence soon cast doubt on the theory that EBV could be the only thing causing CFS. High levels of EBV antibodies (disease-fighting proteins) have now been found in some healthy people as well as in some people with CFS. Likewise, some people who don't have EBV antibodies, and who thus have never been infected with the virus, can show CFS symptoms. How is CFS Diagnosed? Doctors find it difficult to diagnose CFS because it has the same symptoms as many other diseases. When talking with and examining you, your doctor must first rule out diseases that look similar, such as multiple sclerosis and systemic lupus erythematosus in which symptoms can take years to develop. In follow-up visits, you and your doctor need to be alert to any new cues or symptoms that might show that the problem is something other than CFS. When other diseases are ruled out and if your illness meets other criteria as well, your doctor can diagnose you with CFS (see The CFS Case Definition). The CFS Case Definition The EBV work sparked new interest in the syndrome among a small group of medical researchers. They realized they needed a standard way to describe CFS so that they could more easily compare research results. In the late 1980s, CDC brought together a group of CFS experts to tackle this problem. Based on the best information available at the time, this group published in the March 1988 issue of the scientific journal, Annals of Internal Medicine, strict symptom and physical criteria -- the first case definition -- by which scientists could evaluate CFS study patients. Not knowing the cause or a specific sign for the disease, the group agreed to call the illness " chronic fatigue syndrome " after its primary symptom. " Syndrome " means a group of symptoms that occur together but can result from different causes. (Today, CFS also is also known as: " myalgic encephalomyelitis " , " postviral fatigue syndrome " , " chronic fatigue " or " immune dysfunction syndrome " .) Prescription drugs, such as anti-hypertensives (blood-pressure meds), birth control pills, or sedatives may 'trigger' chronic fatigue. How Can I Cope With and Manage the Illness? There is no effective allopathic treatment for CFS. Even though there is no specific treatment for CFS itself, you may find it quite helpful to treat your own symptoms. Learning how to manage your fatigue may help you improve the level at which you can function and your quality of life despite your symptoms. A qualified naturopath can evaluate and teach you how to plan activities to take advantage of times when you usually feel better. Conclusion- CFS seems to involve interactions between the immune and central nervous systems, interactions about which scientists know relatively little. Scientists' concerted efforts to penetrate the complex nervous system and immune system events in CFS have created a challenging new concept of the pathology of this and other illnesses. _______________ References: 1. De Lorenzo F, Hargreaves J, Kakkar VV. Pathogenesis and management of delayed orthostatic hypotension in patients with chronic fatigue syndrome. Clin Auton Res 1997;7:185–90. 2. Fulcher KY, White PD. Randomised controlled trial of graded exercise in patients with the chronic fatigue syndrome. Br Med J 1997;314:1647–52. 3. McCully KK, Sisto SA, Natelson BH. Use of exercise for treatment of chronic fatigue syndrome. Sports Med 1996;21:35–48 [review]. 4. 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Clin Infect Dis 1994;18 (suppl 1):S62–7. 19. Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of chronic fatigue syndrome. Neuropsycholbiol 1997;35:16–23. 20. Forsyth LM, Preuss HG, MacDowell AL, et al. Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome. Ann Allergy Asthma Immunol 1999;82:185–91. 21. Cox IM, Campbell MJ, Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet 1991;337:757–60. 22. Howard JM, Davies S, Hunnisett A. Magnesium and chronic fatigue syndrome. Lancet 1992;340:426. 23. Clague JE, Edwards RH, Jackson MJ. Intravenous magnesium loading in chronic fatigue syndrome. Lancet 1992;340:124–5. 24. Gantz NM. Magnesium and chronic fatigue. Lancet 1991;338:66 [letter]. 25. Hinds G, Bell NP, McMaster D, McCluskey DR. Normal red cell magnesium concentrations and magnesium loading tests in patients with chronic fatigue syndrome. Ann Clin Biochem 1994;31(Pt. 5):459–61. 26. Kuratsune H, Yamaguti K, Sawada M, et al. Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome. Int J Mol Med 1998;1:143–6. 27. De Becker P, De Meirleir K, Joos E, et al. Dehydroepiandorsterone (DHEA) response to i.v. ACTH in patients with chronic fatigue syndrome. Horm Metab Res 1999;31:18–21. 28. Bou-Holaigah I, Rowe PC, Kan J, Calkins H. The relationship between neurally mediated hypotension and the chronic fatigue syndrome. JAMA 1995;274:961–7. 29. Whorwood CB, Shepard MC, Stewart PM. Licorice inhibits 11ß-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action. Endocrinology 1993;132:2287–92. 30. Baschetti R. Chronic fatigue syndrome and liquorice. New Z Med J 1995;108:156–7 [letter]. 31. Brown D. Licorice root—potential early intervention for chronic fatigue syndrome. Quart Rev Natural Med 1996;Summer:95–7. 32. Price JR, Couper J. Cognitive behaviour therapy for adults with chronic fatigue syndrome. Cochrane Database Syst Rev 2000; (2):CD001027 [review]. -- This information is for informational purposes only. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your naturopathic doctor or practitioner for any health problem and before using any supplements or before making any changes in medications. _________________ JoAnn Guest mrsjo- DietaryTi- www.geocities.com/mrsjoguest/Genes AIM Barleygreen " Wisdom of the Past, Food of the Future " http://www.geocities.com/mrsjoguest/Diets.html Quote Link to comment Share on other sites More sharing options...
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