Elaeocarpus sphaericus Studies

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Phytomedicine. 2000 Jun;7(3):205-7. Related Articles, Links

 

Studies on extracts of Elaeocarpus sphaericus fruits on in vitro rat mast cells.

 

Singh RK, Bhattacharya SK, Acharya SB.

 

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu

University, Varanasi, India.

 

 

 

Elaeocarpus sphaericus (Syn: E. ganitrus), in Ayurvedic Medicine commonly known

as Rudraksha is known to have wide range of pharmacological activities. We

reported previously the protective action of E. sphaericus in experimental

bronchial asthma. The present study on rat mesenteric mast cell was undertaken

to investigate the effect of E. sphaericus fruits on autacoid release. The

petroleum ether (PE), benzene (BE), chloroform (CE), acetone (AE) and ethanol

(EE) extracts of E. sphaericus fruits were found to have mast-cell stabilizing

activity, substantiating the efficacy of E. sphaericus against bronchial asthma.

 

PMID: 11185731 [PubMed - indexed for MEDLINE]

 

 

 

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Phytother Res. 2000 Feb;14(1):36-9. Related Articles, Links

 

Pharmacological activity of Elaeocarpus sphaericus.

 

Singh RK, Acharya SB, Bhattacharya SK.

 

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu

University, Varanasi - 221 005, India.

 

 

 

Elaeocarpus sphaericus fruits are used in Ayurveda for mental diseases,

epilepsy, asthma, hypertension, arthritis and liver diseases. Sequential

petroleum ether (PE), benzene (BE), chloroform (CE), acetone (AE) and ethanol

(EE) extracts (50-200 or 200 mg/kg, ip, or 200 mg/kg, po) of dried Elaeocarpus

sphaericus fruits, pretreatment time 30-45 min, showed significant

antiinflammatory action against both acute and sub-acute models, analgesic,

barbiturate-hypnosis potentiation and antiulcerogenic activities in rats. All

the extracts, except PE and EE decreased swim stress immobility in mice

indicating some degree of antidepressant activity. All the extracts protected

guinea-pigs against bronchospasm induced by histamine and acetylcholine

aerosols. Chemically, the extracts showed the presence of glycosides, steroids,

alkaloids and flavonoids. Copyright 2000 John Wiley & Sons, Ltd.

 

PMID: 10641045 [PubMed - indexed for MEDLINE]

 

 

 

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Phytother Res. 1999 Aug;13(5):448-50. Related Articles, Links

 

Antimicrobial activity of Elaeocarpus sphaericus.

 

Singh RK, Nath G.

 

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu

University, Varanasi - 221 005, India.

 

 

 

Antibacterial activity of petroleum ether (PE), benzene (BE), chloroform (CE),

acetone (AE) and ethanol (EE) extracts of dried Elaeocarpus sphaericus fruit was

investigated against 28 gram-positive and gram-negative bacteria using the disc

diffusion and plate dilution methods. The AE fraction showed marked

antimicrobial activity against ten organisms. BE was active against Salmonella

typhimurium and Morganella morganii, and EE against Plesiomonas shigelloides,

Shigella flexnerii and Sh. sonneii. The alkaloids and flavonoids present in the

plant appear to be of chemotherapeutic interest. Copyright 1999 John Wiley &

Sons, Ltd.

 

PMID: 10441793 [PubMed - indexed for MEDLINE]