Herb Used To Treat Diabetes Works Like Modern-Day Prescription

[Guest guest]

Better take a little ginger with that.

 

http://www.bio.com/newsfeatures/newsfeatures_research.jhtml?cid=7800106

 

 

Herb Used To Treat Diabetes Works Like Modern-Day Prescription Drugs, Study

Suggests

 

02/14/05 -- An herb used in traditional Indian medicine to treat diabetes

seems to lower blood sugar and insulin levels in a manner similar to

prescription drugs, a new study reports.

Researchers gave extracts of the herb Salacia oblonga to 39 healthy adults,

and the results were promising. The largest dose of the herb extract - 1,000

milligrams - decreased insulin and blood glucose levels by 29 and 23

percent, respectively.

 

 

 

print

this page

email

this page

 

"These kinds of reductions are similar to what we might see with

prescription oral medications for people with diabetes," said Steve

Hertzler, a study co-author and an assistant professor of nutrition at Ohio

State University.

 

Salacia oblonga, which is native to regions of India and Sri Lanka, binds to

intestinal enzymes that break down carbohydrates in the body. These enzymes,

called alpha-glucosidases, turn carbohydrates into glucose, the sugar that

circulates throughout the body. If the enzyme binds to the herbal extract

rather than to a carbohydrate, then less glucose gets into the blood stream,

resulting in lowered blood glucose and insulin levels.

 

"Lowering blood glucose levels lowers the risk of disease-related

complications in people with diabetes," Hertzler said. "Also, poor

compliance with diabetes medications often hinders the effectiveness of

these drugs. It may be easier to get someone to take an herb with food or in

a beverage, as opposed to a pill."

 

The study appears in a recent issue of the Journal of the American Dietetic

Association.

 

Thirty-nine healthy adults participated in four separate meal tolerance

tests. These meals, which were given in beverage form, were spaced three to

14 days apart. Each participant fasted for at least 10 hours before

consuming the test beverage.

 

Participants were asked to drink about two cups' worth of the chilled

beverage, which contained zero, 500, 700 or 1,000 milligrams of Salacia

oblonga extract. Afterward, the researchers used the finger-prick method to

draw blood samples from each person every 15 to 30 minutes for three hours.

These blood samples were used to determine insulin and blood glucose

concentrations. The biggest changes in blood glucose and insulin levels

usually happen within the first two hours after eating.

 

The beverage that contained the highest concentration of the herbal

extract - 1,000 milligrams - provided the most dramatic reduction in insulin

and blood glucose levels. Insulin levels were 29 percent lower, while blood

glucose levels were 23 percent lower as compared to the control drink, which

contained no herbal extract.

 

As Salacia oblonga can cause intestinal gas, the researchers had the study

participants collect breath hydrogen samples hourly for eight hours after

drinking the test beverage. The participants collected their breath in small

plastic tubes. The researchers then analyzed these breath samples for

hydrogen and methane content - the level of either substance in the breath

corresponds to the level contained in the colon.

 

The subjects also rated the frequency and intensity of nausea, abdominal

cramping and distention and gas for two days after consuming each test meal.

 

While the test beverages containing Salacia oblonga caused an increase in

breath hydrogen excretion, reports of gastrointestinal discomfort were

minimal, Hertzler said.

 

Right now he and his colleagues are trying to figure out what dose of the

herb is most effective, and when it should be taken relative to a meal.

 

"We want to know how long it takes for the herb to bind to the enzymes that

break down carbohydrates," Hertzler said. "The participants in this study

took the herb with their meal, but maybe taking it before eating would be

even more effective."

 

The researchers also want to study the effects of Salacia oblonga in people

with diabetes.

 

"A lot of studies show that lowering blood sugar levels reduces the risk for

all kinds of diabetes-related complications, such as kidney disease and

nerve and eye damage," Hertzler said. "We want to see if this herb has this

kind of effect."

 

Salacia oblonga is still relatively difficult to find in the United States,

Hertzler said, although there are manufacturers that sell the herb through

the Internet.

 

This study was supported by the Ross Products Division of Abbott

Laboratories in Columbus.

 

Hertzler is continuing to conduct Salacia oblonga studies with the Ross

Products Division of Abbott Laboratories. He has no links to the company

beyond this affiliation.

 

Hertzler conducted the work with former Ohio State colleague Patricia

Heacock, who is now at Rutgers, the State University of New Jersey; Jennifer

Williams, a clinical scientist with Ross Products Division, Abbott

Laboratories; and Bryan Wolf, a former research scientists with Ross

Products Division.

 

Source: Ohio State University