Fw: Paget - Little-known form of breast cancer

March 4, 2002

Hopefully no one will ever need to use this information, but just to be safe...

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Monday, March 04, 2002 5:03 AM

Paget - Little-known form of breast cancer

This was sent to me by my friend Meliza Myrick. I've added more at the end,

including some web sites. Please read and forward. David.

Ladies PLEASE take the time

to read the following message. It is a new form of breast cancer that we

should all be aware of! I hope you will forward this to all of your female

friends. In November, I lost my sister to a rare kind of breast

cancer. She developed a rash on her breast, similar to that of young

mothers who are nursing. Because her mammogram had been clear, the doctor

treated her with antibiotics for infections. After 2 rounds and it

continued to get worse, her doctor sent her for another mammogram, and this

time it showed a mass. A biopsy found a fast growing malignancy. Chemo was

started in order to shrink the growth; then mastectomy; then a full round of

chemo; then radiation. After about 9 months of intense treatment, she was

given a clean bill of health. One year of living each day to its fullest

– then it returned to the liver area. She took 4 treatments and decided

that she wanted quality of life not the after effects of chemo. We had 5

great months and she planned each detail of the final days. After just a

few days of needing morphine, she slipped away saying she had done what God had

sent her into the world to do and now it was her time to go. I

still have tears as I write, but her message is shown below. And PLEASE be

alert to any thing that is not normal and be persistent in getting help as soon

as possible. RARE FORM OF BREAST CANCER – PAGET’s DISEASE

{ from Juanita Bush } This is a rare form of breast

cancer and is on the outside of the breast, on the nipple and aureole. It

appeared as a rash which later became a lesion with a crusty outer edge. I

would not have ever suspected it to be breast cancer but it was. My nipple

never seemed any different to me but the rash bothered me, so I went to the

doctor for that. Sometimes it itched and was sore, but other than that it

didn’t bother me. It was just ugly and a nuisance and could not be

cleared up with all the creams prescribed by my doctor and dermatologist for

the dermatitis on my eyes just prior to this outbreak. They seemed a little

concerned but did not warn me it could be cancerous. Now I suspect there are

not many women out there who know a lesion or rash on the nipple or aureole can

be breast cancer. Mine started out as a single red pimple on the aureole. One

of the biggest problems with Paget’s disease of the nipple is that the

symptoms appear to be harmless. It is frequently thought to be a skin

inflammation or infection, leading to unfortunate delays in detection and care.

What are the symptoms? The symptoms include : (1) A persistent

redness, oozing, and crusting of your nipple causing it to itch and Burn. (As

I stated, mine did not itch or burn much, and had no oozing I was

aware of, but it did have a crust along the outer edge on one side). (2) A

sore on your nipple that will not heal. (Mine was on the aureole area with a

whitish thick looking area in center of nipple). (3) Usually

only one nipple is affected. How is it diagnosed? Your doctor

will do a physical exam and should suggest having a mammogram of both breasts,

done immediately. Even though the redness, oozing and crusting closely

resemble dermatitis (inflammation of the skin), your doctor should suspect

cancer if the sore is only on one breast. Your doctor should order a biopsy of

your sore to confirm what is going on. They will take a sample of your breast

tissue in that area to test for cancer. If the cancer is only in the nipple

and not in the breast, your doctor may recommend just removing the nipple and

surrounding tissue or suggest radiation treatments. Had my doctor caught mine

right away instead of flaking it off as dermatitis, perhaps they could have

saved my breast and it wouldn’t have gone to my lymph nodes.

This message should be taken seriously and passed on to as many of your

friends as possible; it could save someone’s life. My breast cancer has

spread and metastasized to my bones after receiving mega doses of chemotherapy,

28 treatments of radiation and taking tamaxofin. If this had been diagnosed as

breast cancer in the beginning, perhaps it would not have spread. TO ALL

READERS : This is sad as women are not aware of Paget’s disease. If by

passing this around on the e-mail we can make others aware of it and its

potential danger, we are helping women everywhere. Please if you can, take a

moment to forward this message to as many people as possible especially to your

family and friends. It only takes a moment – yet the results could save a

life! _________ I found some references -

URLs are at the end of this message. This is from

http://www.longerliving.com/paget.htm Paget's Disease: A rare form of breast

cancer By Laura Ruth, Ph.D. Currently Paget's disease can be

classified as mammary Paget's disease (MPD), which affects the breast nipple,

and extramammary Paget's disease (EMPD), which can affect the vulva,

perineum, penis, scrotum, anorectal tissues, urethra, or cutaneous adnexal

glands, as well as umbilical, presternal, eyelids, and external ear canal

skin. INCIDENCE Paget's disease of the breast is a rare disease which

affects 3-5% of all mammary abnormalities. 1-4% of female patients with

breast cancer develop MPD. Of the 1% reported male malignant breast cancer,

7.4 - 10.6% of the male patients with breast cancer (fifty-six cases total)

are reported to have MPD. DIAGNOSIS AND TREATMENT Paget's disease affects

groups ranging from forty to eighty years, with an average age of sixty years.

In females, the average delay between the onset of clinical symptoms and

deciding on treatment averages twelve to fourteen months, while in males the

average delay between detection and treatment is eight years. Both types of

Paget's disease can represent an extension of a carcinoma under the skin or in

the case of EMPD Paget's disease, an intraepithelial adenocarcinoma from the

basal layer of skin. The clinician-pathologist Sir James Paget first reported

Paget's disease in 1874 by describing fifteen women with eczema around their

nipples associated with breast cancer. In both MPD and EMPD the affected skin

presents as red and scaly plaques. The underlying nodules may surface, become

crusted, exudative, very hard, itchy, ulcerative, and can bleed. The Paget's

growth is slow-growing and may become painful. Paget's disease can also

metastasize to the lymph nodes. Diagnosis of MPD and EMPD can be difficult

because not all patients have clinical symptoms or the disease is in an early

stage (i.e. there are no surface skin markers, such as redness, scaling or

crusting, or the redness can be mistaken for a skin problem, such as

dermatitis.) Topical steroids, however, will not ameliorate the "dermatitis".

Although it is rare according to Dr. Sabine Kohler of the Laboratory of

Surgical Pathology at Stanford University Medical Center , Paget's disease of

the breast can be misdiagnosed as intraepithelial squamous cell cancer

(Bowen's disease), superficial spreading basal cell carcinoma, and malignant

melanoma. The disease is definitively diagnosed by a biopsy followed by

histological methods, which stain and identify the malignant Paget cells.

Treatment of a definitively diagnosed case of Paget's disease will depend on

the stage of the cancer. For example, if the area of skin affected is limited

in MPD, removal of the affected nipple may be adequate treatment. If the

carcinoma is more advanced, a modified or radical mastectomy with ipsilateral

axillary lymph node dissection, postoperative irradiation, and/or chemotherapy

may be advisable methods of treatment. Posted September 1999

-- http://www.paget.org/

http://www.paget.org/index.asp?p=Information%2Fbreast%5Ffr%5Fbottom%2Easp%23patients

http://www.paget.org.uk/ http://www.fda.gov/fdac/features/896_pag.html

_ David William Brown. Author, "An

Introduction to Object-Oriented Analysis, Objects and UML in

Plain English" www.wiley.com

http://jws-edcv.wiley.com/college/tlp/0,9842,BUSC-ISC-IS41C_0471371378_BKS,00.html

March 6, 2002

someone wanted the mail on women and cancer. Here is the messge/mail forwarded

for the benefit of one and all

EG

- Nimmi Ragavan

Wayne Frost ; varahamihira ; vedic astrology

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Monday, March 04, 2002 2:55 PM

[vedic astrology] Fw: Paget - Little-known form of breast cancer