turmeric

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Curry spice 'help for arthritis'

 

Turmeric adds flavour and colour to curries and other foods

Extract of a spice used in curry could help prevent rheumatoid arthritis and

osteoporosis, US research suggests.

Turmeric has been used for centuries in Asian medicine to treat inflammatory

disorders and its extract can be found in western dietary supplements.

Now lab work by University of Arizona researchers, in Arthritis &

Rheumatism, shows just how the spice's curcuminoid extracts have a

therapeutic effect.

Experts say new drugs may be found, but eating more spices is unlikely to

work.

The researchers said clinical trials were needed before turmeric supplements

could be recommended for medicinal use.

Turmeric extract

Earlier work by the University of Arizona team showed turmeric could prevent

joint inflammation in rats.

In their latest study, they set out to find exactly what ingredient in

turmeric was having the anti-inflammatory effect.

They prepared extracts from the rhizome, or root of the turmeric plant, and

compared them against the commercially available products that contain

turmeric extracts.

 

Results of tests in animal models of arthritis are not always reproduced in

human rheumatoid arthritis.

 

Dr Ann Barton, Manchester University

A version of turmeric extract that was free of essential oils was found to

most closely match the composition of the commercial supplements.

And it was this extract, containing curcumin, that was most effective at

blocking the onset of rheumatoid arthritis in the rats.

The extract appears to work by preventing a protein that controls when genes

are switched on or off from being activated in the joint.

Once the protein known as NF-KB is activated, it binds to genes and

increases the production of inflammatory proteins, which attack the joints.

Dr Janet Funk and her colleagues believe their findings also suggest

turmeric extract could treat other inflammatory disorders, including asthma,

multiple sclerosis and inflammatory bowel disease.

The extract also blocked a pathway in the body linked to bone loss,

suggesting it could treat osteoporosis as well.

Future work

Professor Robert Moots, professor of rheumatology at Liverpool University

and spokesman for the Arthritis Research Campaign, said people with

arthritis will have to wait to see if the study results in new treatments.

"It will come as no surprise if naturally occurring compounds have a

drug-like effect," he said.

"I do not think there is any evidence that countries that eat a lot of

turmeric have a lower frequency of rheumatoid arthritis. So simply eating

more spices is not likely to be effective clinically.

"What is more likely is these results will lead to the targeted development

of new compounds."

Dr Anne Barton, senior lecturer and honorary consultant rheumatologist at

the University of Manchester said: "The findings are interesting but should

be interpreted with some caution at this stage.

"Results of tests in animal models of arthritis are not always reproduced in

human rheumatoid arthritis.

"As the authors point out though, there are a number of successful drug

therapies that have been developed from plants."