Re:The Life and Death of a Neuron / Mandukaparni

[Guest guest]

Dear Soutrik,

Mandukaparni or Sarswati(Centella asciatica) is the best herb that i would recommend you to use regularly owing to its high potential ability to cope up to daily stress and nerve regaenerative actions.

This herb holds top priority among the medhya-rasayanas in ayurveda.

Hopefully a styudy supports this traditional claim.

Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro

Auteur(s) / Author(s) SOUMYANATH Amala ; ZHONG Yong-Ping ; GOLD Sandra A. ; XIAOLIN YU ; KOOP Dennis R. ; BOURDETTE Dennis ; GOLD Bruce G. ;

Résumé / Abstract Axonal regeneration is important for functional recovery following nerve damage. Centella asiatica Urban herb, also known as Hydrocotyle asiatica L., has been used in Ayurvedic medicine for centuries as a nerve tonic. Here, we show that Centella asiatica ethanolic extract (100 μg mL[-][1]) elicits a marked increase in neurite outgrowth in human SH-SY5Y cells in the presence of nerve growth factor (NGF). However, a water extract of Centella was ineffective at 100 μg mL[-][1]. Sub-fractions of Centella ethanolic extract, obtained through silica-gel chromatography, were tested (100 μg mL[-][1]) for neurite elongation in the presence of NGF. Greatest activity was found with a non-polar fraction (GKF4). Relatively polar fractions (GKF10 to GKF13) also showed activity, albeit less than GKF4. Thus, Centella contains more than one active component. Asiatic acid (AA), a triterpenoid compound found in Centella ethanolic extract and GKF4, showed

marked activity at 1 μM (0.5 μg mL[-][1]). AA was not present in GKF10 to GKF13, further indicating that other active components must be present. Neurite elongation by AA was completely blocked by the extracellular-signal-regulated kinase (ERK) pathway inhibitor PD 098059 (10 μM). Male Sprague-Dawley rats given Centella ethanolic extract in their drinking water (300-330 mg kg[-][1] daily) demonstrated more rapid functional recovery and increased axonal regeneration (larger calibre axons and greater numbers of myelinated axons) compared with controls, indicating that the axons grew at a faster rate. Taken together, our findings indicate that components in Centella ethanolic extract may be useful for accelerating repair of damaged neurons.

 

Journal of pharmacy and pharmacology (J. pharm. pharmacol.) ISSN 0022-3573 CODEN JPPMAB

 

Dr.Venu Gopal Rao.T

M.D(Ayu)

 

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> Is there any ayurvedic method to regenrate Neurons and have a strong nervous system to cope up to daily stress.