Guest guest Posted June 19, 2003 Report Share Posted June 19, 2003 ---------- HSI - Jenny Thompson <hsiweb Vitamin Blue Health Sciences Institute e-Alert June 19, 2003 ************************************************************** Dear Reader, It isn't necessarily news that the problems associated with bone fractures create especially worrisome concerns for postmenopausal women. But a new study shows that for women who use antidepressant drugs, those concerns should be taken even more seriously. This just adds one more reason to consider natural and nutritional options before accepting anti-depressant medications. ----------------------------- Fractured blues ----------------------------- For over four years, researchers at the Veterans Affairs Medical Center in Minneapolis followed a group of more than 8,000 women over the age of 65 who were taking central nervous system (CNS) medications. The four types of prescription medications included in the study were: antidepressants (SSRIs such as Prozac and Paxil), pain-relief narcotics, anticonvulsants, and anxiety treatments (such as Xanax). When these women were compared to unmedicated women, the researchers found that the use of antidepressant and narcotic drugs significantly increased the risk of non-spine fractures, while the other two drug types apparently had little effect on the incidence of fractures. But when the statistics were isolated for antidepressant drug use alone, the result was shocking, revealing a 70 percent increased risk of hip fractures. These results were attributed to the probable impairment of mental faculties - one of the side effects of antidepressant drugs that often leads to accidents. So while it would be incorrect to say that bone fractures are a direct side effect of antidepressants, this study draws a clear association between the two for elderly women. ----------------------------- The folate connection ----------------------------- I just happened to come across the Minneapolis study at about the same time I found another study that investigated the relationship of the B vitamin nutrient folate to depression. While other studies have already made the connection between depression and low levels of folate in clinical trials, this research - from the USDA Human Nutrition Research Center on Aging at Tufts University - is the first to study the association among a large segment of the general population. Researchers examined data from blood tests of almost 3,000 subjects, aged 15 to 39. Through diagnostic interviews, the research team found that subjects who had major depression and subjects who had mild depression both had low red blood cell folate concentrations. An editorial that accompanies the publication of the study in the journal Psychotherapy and Psychosomatics points out that while the results of this and other studies on folate and depression are promising, not enough research has been done to suggest a proper dosage for folate supplements, or exactly who should receive them, or for how long. Within the context of clinical research that sort of caution is expected. But out here in the real world it's not too early to recognize that someone who's depressed would almost certainly help their cause to include folate-rich foods in their diet, along with a supplement of folic acid. ----------------------------- All this, and more... ----------------------------- Taken together, these two studies offer important considerations to any older woman who may be taking prescription antidepressants or weighing the option to do so. Will folate " cure " depression? That's doubtful. But folate provides a nutritious step in the right direction. In the e-Alert " The Power Of The Single Word " (8/8/02) I told you how you about these dietary sources of folate: liver, asparagus, lentils, chickpeas, most varieties of beans, and especially spinach and other leafy green vegetables. Folic acid is the synthetic form of folate that you'll find in most multi-vitamins. And as I mentioned in that August e-Alert, when vitamins B6 and B12 are added to folic acid supplements, you may get the added benefit of a lower homocysteine level. And as if that weren't enough, folate may provide yet another benefit. In the May 2003 HSI Members Alert we told you how folate intake may help prevent breast cancer. According to a recent Harvard study, women with high levels of folate who also drank alcohol in moderation were 89 percent less likely to develop breast cancer than women whose folate levels were lowest. The advantage of a folate-rich diet isn't news to HSI members. But for any older woman who may be considering the use of a prescription drug to address depression, this new information about bone fracture risk will provide a fresh reminder that treating health problems with pharmaceuticals may open up dangers that don't always appear on the warning panel. ************************************************************** Sources: " Central Nervous System Active Medications and Risk for Fractures in Older Women " Archives of Internal Medicine 2003;163:949-957, 4/28/03, archinte.ama-assn.org " Antidepressants Raise Bone Fracture Risk " Jennifer Warner, WebMD Medical News, 4/28/03, content.health.msn.com " Depression and Folate Status in the US Population " Psychotherapy and Psychosomatics 2003;72:80-87, content.karger.com " Folic Acid May Ease Depression " Farret Condon, Hartford Courant, 6/5/03, ctnow.com Copyright ©1997-2003 by www.hsibaltimore.com, L.L.C. The e-Alert may not be posted on commercial sites without written permission. ************************************************************** Before you hit reply to send us a question or request, please click here http://www.hsibaltimore.com/ealert/questions.html Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 20, 2003 Report Share Posted June 20, 2003 Thu, 19 Jun 2003 12:56:30 -0500 HSI - Jenny Thompson Vitamin Blue Vitamin Blue Health Sciences Institute e-Alert June 19, 2003 ************************************************************** Dear Reader, It isn't necessarily news that the problems associated with bone fractures create especially worrisome concerns for postmenopausal women. But a new study shows that for women who use antidepressant drugs, those concerns should be taken even more seriously. This just adds one more reason to consider natural and nutritional options before accepting anti-depressant medications. ----------------------------- Fractured blues ----------------------------- For over four years, researchers at the Veterans Affairs Medical Center in Minneapolis followed a group of more than 8,000 women over the age of 65 who were taking central nervous system (CNS) medications. The four types of prescription medications included in the study were: antidepressants (SSRIs such as Prozac and Paxil), pain-relief narcotics, anticonvulsants, and anxiety treatments (such as Xanax). When these women were compared to unmedicated women, the researchers found that the use of antidepressant and narcotic drugs significantly increased the risk of non-spine fractures, while the other two drug types apparently had little effect on the incidence of fractures. But when the statistics were isolated for antidepressant drug use alone, the result was shocking, revealing a 70 percent increased risk of hip fractures. These results were attributed to the probable impairment of mental faculties - one of the side effects of antidepressant drugs that often leads to accidents. So while it would be incorrect to say that bone fractures are a direct side effect of antidepressants, this study draws a clear association between the two for elderly women. ----------------------------- The folate connection ----------------------------- I just happened to come across the Minneapolis study at about the same time I found another study that investigated the relationship of the B vitamin nutrient folate to depression. While other studies have already made the connection between depression and low levels of folate in clinical trials, this research - from the USDA Human Nutrition Research Center on Aging at Tufts University - is the first to study the association among a large segment of the general population. Researchers examined data from blood tests of almost 3,000 subjects, aged 15 to 39. Through diagnostic interviews, the research team found that subjects who had major depression and subjects who had mild depression both had low red blood cell folate concentrations. An editorial that accompanies the publication of the study in the journal Psychotherapy and Psychosomatics points out that while the results of this and other studies on folate and depression are promising, not enough research has been done to suggest a proper dosage for folate supplements, or exactly who should receive them, or for how long. Within the context of clinical research that sort of caution is expected. But out here in the real world it's not too early to recognize that someone who's depressed would almost certainly help their cause to include folate-rich foods in their diet, along with a supplement of folic acid. ----------------------------- All this, and more... ----------------------------- Taken together, these two studies offer important considerations to any older woman who may be taking prescription antidepressants or weighing the option to do so. Will folate " cure " depression? That's doubtful. But folate provides a nutritious step in the right direction. In the e-Alert " The Power Of The Single Word " (8/8/02) I told you how you about these dietary sources of folate: liver, asparagus, lentils, chickpeas, most varieties of beans, and especially spinach and other leafy green vegetables. Folic acid is the synthetic form of folate that you'll find in most multi-vitamins. And as I mentioned in that August e-Alert, when vitamins B6 and B12 are added to folic acid supplements, you may get the added benefit of a lower homocysteine level. And as if that weren't enough, folate may provide yet another benefit. In the May 2003 HSI Members Alert we told you how folate intake may help prevent breast cancer. According to a recent Harvard study, women with high levels of folate who also drank alcohol in moderation were 89 percent less likely to develop breast cancer than women whose folate levels were lowest. The advantage of a folate-rich diet isn't news to HSI members. But for any older woman who may be considering the use of a prescription drug to address depression, this new information about bone fracture risk will provide a fresh reminder that treating health problems with pharmaceuticals may open up dangers that don't always appear on the warning panel. ************************************************************** ...and another thing It only takes about three minutes of searching through the aisles of a nutritional supplement store to realize that the variety of choices can be dizzying. Consequently, there seems to be no end to questions about vitamin supplements from HSI members. No problem. We've got HSI Panelist Allan Spreen, M.D., in the house, standing by with the answers. Today we have two questions that go together nicely. Question one comes from a member named Hank who writes: " In choosing a multi-vitamin/mineral supplement, how much more absorption does a person get by using the liquid form over the capsule/pill form? I've heard that much of the pill goes through the body without being dissolved and absorbed? " And a member named Kevin provides question two: " What are the differences between time-released vitamins and regular one? Is time-released better than regular? Do you get more benefits from, or absorb more of the vitamins and minerals from the time-released pills? " Both are very good questions, and Dr. Spreen starts off by addressing Hank's first: " There are a few (read that a FEW) pill forms that break down quickly, but they are rare. I always use capsule, powder or liquid forms whenever possible, as they at least guarantee that the individual gets what he swallows (whether the dose is adequate is another issue). " For the same reason I don't use time-release forms, as you're then using a preparation deliberately designed not to give its contents to you. I prefer to have the individual be his own 'time-releaser' by multiple dosing throughout the day. " One caveat to what preparation is used is to make certain you know the dose amounts of the contents. Some products hedge on that, and as good as they may be, you have no way of evaluating just what you're paying for. " Sound advice, as always, from Dr. Spreen - clearing up all of your supplement questions one (and sometimes two) at a time. To Your Good Health, Jenny Thompson Health Sciences Institute ************************************************************** Sources: " Central Nervous System Active Medications and Risk for Fractures in Older Women " Archives of Internal Medicine 2003;163:949-957, 4/28/03, archinte.ama-assn.org " Antidepressants Raise Bone Fracture Risk " Jennifer Warner, WebMD Medical News, 4/28/03, content.health.msn.com " Depression and Folate Status in the US Population " Psychotherapy and Psychosomatics 2003;72:80-87, content.karger.com " Folic Acid May Ease Depression " Farret Condon, Hartford Courant, 6/5/03, ctnow.com Copyright ©1997-2003 by www.hsibaltimore.com, L.L.C. The e-Alert may not be posted on commercial sites without written permission. ************************************************************** Before you hit reply to send us a question or request, please click here http://www.hsibaltimore.com/ealert/questions.html ************************************************************** Gettingwell- / Vitamins, Herbs, Aminos, etc. To , e-mail to: Gettingwell- Or, go to our group site: Gettingwell SBC DSL - Now only $29.95 per month! Quote Link to comment Share on other sites More sharing options...
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