Guest guest Posted September 8, 2009 Report Share Posted September 8, 2009 Below are: (1) an input from one of the websites on hemp oil stating basil and oregano got beta-caryophyllene a component of cannabinoids. (2) i searched beta-caryophyllene and see for yourself the results. Do you think this can be used for the big C? Melly ============== BETA-CARYOPHYLLENE (Herbs Basil & Oregano) IS A DIETARY CANNABINOID Beta-caryophyllene selectively binds to the CB2 receptor and is a functional CB2 agonist. Pub Med # 18574142 Marijuana contains an amazing chemical, beta-caryophyllene, and scientists have thoroughly proven that it could be used to treat pain, inflammation, atherosclerosis, and osteoporosis. Jürg Gertsch, of ETH Zürich, and his collaborators from three other universities learned that the natural molecule can activate a protein called cannabinoid receptor type 2. When that biological button is pushed, it soothes the immune system, increases bone mass, and blocks pain signals — without causing euphoria or interfering with the central nervous system. Gertsch and his team published their findings on June 23 in the Proceedings of the National Academy of Sciences.They focused on the anti-inflammatory properties of the impressive substance — testing it on immune cells called monocytes and also in mice. Since beta-caryophyllene seems to be powerful, occurs naturally in many foods, and does not get people high, it could turn out to be a nearly ideal medication. The organic compound is also phenomenally cheap. Sigma Aldrich sells it, in kosher form, for forty-two dollars per kilogram. Unfortunately, big pharmaceutical companies tend not to seek FDA approval for natural chemicals, and most doctors are reluctant to prescribe drugs that have not received a green light from the regulatory agency. Thus, it would require a heroic effort by academic researchers to prove that beta-caryophyllene is safe and effective in humans. Perhaps, before that happens, the natural substance will find its way into the herbal medicine aisle of health food stores. ============== Beta-caryophyllene is a dietary cannabinoid. Gertsch J, Leonti M, Raduner S, Racz I, Chen JZ, Xie XQ, Altmann KH, Karsak M, Zimmer A. Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule (ETH) Zurich, 8092 Zürich, Switzerland. juerg.gertsch The psychoactive cannabinoids from Cannabis sativa L. and the arachidonic acid-derived endocannabinoids are nonselective natural ligands for cannabinoid receptor type 1 (CB(1)) and CB(2) receptors. Although the CB(1) receptor is responsible for the psychomodulatory effects, activation of the CB(2) receptor is a potential therapeutic strategy for the treatment of inflammation, pain, atherosclerosis, and osteoporosis. Here, we report that the widespread plant volatile (E)-beta-caryophyllene [(E)-BCP] selectively binds to the CB(2) receptor (K(i) = 155 +/- 4 nM) and that it is a functional CB(2) agonist. Intriguingly, (E)-BCP is a common constituent of the essential oils of numerous spice and food plants and a major component in Cannabis. Molecular docking simulations have identified a putative binding site of (E)-BCP in the CB(2) receptor, showing ligand pi-pi stacking interactions with residues F117 and W258. Upon binding to the CB(2) receptor, (E)-BCP inhibits adenylate cylcase, leads to intracellular calcium transients and weakly activates the mitogen-activated kinases Erk1/2 and p38 in primary human monocytes. (E)-BCP (500 nM) inhibits lipopolysaccharide (LPS)-induced proinflammatory cytokine expression in peripheral blood and attenuates LPS-stimulated Erk1/2 and JNK1/2 phosphorylation in monocytes. Furthermore, peroral (E)-BCP at 5 mg/kg strongly reduces the carrageenan-induced inflammatory response in wild-type mice but not in mice lacking CB(2) receptors, providing evidence that this natural product exerts cannabimimetic effects in vivo. These results identify (E)-BCP as a functional nonpsychoactive CB(2) receptor ligand in foodstuff and as a macrocyclic antiinflammatory cannabinoid in Cannabis Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 10, 2009 Report Share Posted September 10, 2009 Melly,Thanks. I find this quite interesting but have not commented because I haven't had time to really look into it. - Steveoleander soup <oleander soup > ; oleander soup <oleander soup >; cancercured <cancercured >Tue Sep 08 09:49:33 2009 Cannabinoids Below are: (1) an input from one of the websites on hemp oil stating basil and oregano got beta-caryophyllene a component of cannabinoids. (2) i searched beta-caryophyllene and see for yourself the results. Do you think this can be used for the big C?Melly==============BETA-CARYOPHYLLENE (Herbs Basil & Oregano) IS A DIETARY CANNABINOIDBeta-caryophyllene selectively binds to the CB2 receptor and is a functional CB2 agonist.Pub Med # 18574142Marijuana contains an amazing chemical, beta-caryophyllene, and scientists have thoroughly proven that it could be used to treat pain, inflammation, atherosclerosis, and osteoporosis.Jürg Gertsch, of ETH Zürich, and his collaborators from three other universities learned that the natural molecule can activate a protein called cannabinoid receptor type 2. When that biological button is pushed, it soothes the immune system, increases bone mass, and blocks pain signals — without causing euphoria or interfering with the central nervous system.Gertsch and his team published their findings on June 23 in the Proceedings of the National Academy of Sciences.They focused on the anti-inflammatory properties of the impressive substance — testing it on immune cells called monocytes and also in mice.Since beta-caryophyllene seems to be powerful, occurs naturally in many foods, and does not get people high, it could turn out to be a nearly ideal medication. The organic compound is also phenomenally cheap. Sigma Aldrich sells it, in kosher form, for forty-two dollars per kilogram.Unfortunately, big pharmaceutical companies tend not to seek FDA approval for natural chemicals, and most doctors are reluctant to prescribe drugs that have not received a green light from the regulatory agency. Thus, it would require a heroic effort by academic researchers to prove that beta-caryophyllene is safe and effective in humans.Perhaps, before that happens, the natural substance will find its way into the herbal medicine aisle of health food stores. ==============Beta-caryophyllene is a dietary cannabinoid.Gertsch J, Leonti M, Raduner S, Racz I, Chen JZ, Xie XQ, Altmann KH, Karsak M, Zimmer A.Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule (ETH) Zurich, 8092 Zürich, Switzerland. juerg.gertsch (AT) pharma (DOT) ethz.chThe psychoactive cannabinoids from Cannabis sativa L. and the arachidonic acid-derived endocannabinoids are nonselective natural ligands for cannabinoid receptor type 1 (CB(1)) and CB(2) receptors. Although the CB(1) receptor is responsible for the psychomodulatory effects, activation of the CB(2) receptor is a potential therapeutic strategy for the treatment of inflammation, pain, atherosclerosis, and osteoporosis. Here, we report that the widespread plant volatile (E)-beta-caryophyllene [(E)-BCP] selectively binds to the CB(2) receptor (K(i) = 155 +/- 4 nM) and that it is a functional CB(2) agonist. Intriguingly, (E)-BCP is a common constituent of the essential oils of numerous spice and food plants and a major component in Cannabis. Molecular docking simulations have identified a putative binding site of (E)-BCP in the CB(2) receptor, showing ligand pi-pi stacking interactions with residues F117 and W258. Upon binding to the CB(2) receptor, (E)-BCPinhibits adenylate cylcase, leads to intracellular calcium transients and weakly activates the mitogen-activated kinases Erk1/2 and p38 in primary human monocytes. (E)-BCP (500 nM) inhibits lipopolysaccharide (LPS)-induced proinflammatory cytokine expression in peripheral blood and attenuates LPS-stimulated Erk1/2 and JNK1/2 phosphorylation in monocytes. Furthermore, peroral (E)-BCP at 5 mg/kg strongly reduces the carrageenan-induced inflammatory response in wild-type mice but not in mice lacking CB(2) receptors, providing evidence that this natural product exerts cannabimimetic effects in vivo. These results identify (E)-BCP as a functional nonpsychoactive CB(2) receptor ligand in foodstuff and as a macrocyclic antiinflammatory cannabinoid in Cannabis Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.