can a baby aspirin help diabetes and insulin resistance??

[Guest guest]

Weird...check out this abstract from PubMed that says that salicytates

(aspirin) may help reverse diabetes and insulin resistance.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

1533494 & dopt=Abstract

 

Reversal of obesity- and diet-induced insulin resistance with

salicylates or targeted disruption of Ikkbeta.

 

Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE.

 

Joslin Diabetes Center and Department of Medicine, Harvard Medical

School, Boston, MA 02215, USA.

 

We show that high doses of salicylates reverse hyperglycemia,

hyperinsulinemia, and dyslipidemia in obese rodents by sensitizing

insulin signaling. Activation or overexpression of the IkappaB kinase

beta (IKKbeta) attenuated insulin signaling in cultured cells, whereas

IKKbeta inhibition reversed insulin resistance. Thus, IKKbeta, rather

than the cyclooxygenases, appears to be the relevant molecular target.

Heterozygous deletion (Ikkbeta+/-) protected against the development of

insulin resistance during high-fat feeding and in obese Lep(ob/ob) mice.

These findings implicate an inflammatory process in the pathogenesis of

insulin resistance in obesity and type 2 diabetes mellitus and identify

the IKKbeta pathway as a target for insulin sensitization.

 

 

--

Mindy

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" ...that they may be one... "

- Jesus, John 17:22