Guest guest Posted November 20, 2001 Report Share Posted November 20, 2001 > I had a quick look at Mercola's background. In this business you > develop a feel about who can be trusted and who not. Generally > osteopaths, like him, do not fall into the trustworthy category. I > become even more suspicious when they have religious leanings - this guy > seems to be a fundamentalist Christian. Nothing wrong with that but > they tend to have a skewed view of science. There is a great deal of > literature on soy and these scare stories constitute a tiny minority. > The overwhelming evidence is positive. I will not enrol in the Mercola > fan club. A typical left-brain response, that is, if we don't understand it, don't believe it. Pasteur was a tiny minority when he discovered that germs can kill. Joan McPhee, not an M.D. mcpheej Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 21, 2001 Report Share Posted November 21, 2001 Morton Bodanis wrote: When I have a problem accepting information, I ask Dr. Joe Schwarcz for his opinion. He is a professor of Chemistry at McGill University, Montreal, Canada, teacher at Vanier College, author of two current best-selling books on science, frequent guest on the Discovery channel, weekly guest on CJAD radio call-in show, writes a weekly in the Gazette, a Montreal daily, will answer email, etc... So when I read the following, which I could not evaluate, I asked him to. Following the posting quote is his response, put into perspective. Sorry if this is becoming long. (Txt) Soybean implicated in goiter & also inhibits thyroid -NATIONAL LIBRARY OF MEDICINE Fri, 16 Nov 2001 21:45:02 -0800 Gettingwell Entrez-PubMedSoybean implicated in goiter & also inhibits thyroid - NATIONAL LIBRARY OF MEDICINE http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9464451 & form=6 & db=m & Dopt\ =b Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action. Divi RL, Chang HC, Doerge DR. National Center for Toxicological Research, Jefferson, AR 72079, USA. The soybean has been implicated in diet-induced goiter by many studies. The extensive consumption of soy products in infant formulas and in vegetarian diets makes it essential to define the goitrogenic potential. In this report, it was observed that an acidic methanolic extract of soybeans contains compounds that inhibit thyroid peroxidase- (TPO) catalyzed reactions essential to thyroid hormone synthesis. Analysis of the soybean extract using HPLC, UV-VIS spectrophotometry, and LC-MS led to identification of the isoflavones genistein and daidzein as major components by direct comparison with authentic standard reference isoflavones. HPLC fractionation and enzymatic assay of the soybean extract showed that the components responsible for inhibition of TPO-catalyzed reactions coeluted with daidzein and genistein. In the presence of iodide ion, genistein and daidzein blocked TPO-catalyzed tyrosine iodination by acting as alternate substrates, yielding mono-, di-, and triiodoisoflavones. Genistein also inhibited thyroxine synthesis using iodinated casein or human goiter thyroglobulin as substrates for the coupling reaction. Incubation of either isoflavone with TPO in the presence of H2O2 caused irreversible inactivation of the enzyme; however, the presence of iodide ion in the incubations completely abolished the inactivation. The IC50 values for inhibition of TPO-catalyzed reactions by genistein and daidzein were ca. 1-10 microM, concentrations that approach the total isoflavone levels (ca. 1 microM) previously measured in plasma from humans consuming soy products. Because inhibition of thyroid hormone synthesis can induce goiter and thyroid neoplasia in rodents, delineation of anti-thyroid mechanisms for soy isoflavones may be important for extrapolating goitrogenic hazards identified in chronic rodent bioassays to humans consuming soy products. PMID: 9464451 [PubMed - indexed for MEDLINE] Write to the Help Desk NCBI | NLM | NIH Department of Health & Human Services Freedom of Information Act | Disclaimer sparc-sun-solaris2.8 Nov 15 2001 10:41:10 Dr. Schwarcz replies: This is essentially irrelevant. Numerous studies have shown that large doses of soy in animals have goitrogenic effects. This has no bearing on humans consuming normal amounts of soy. We have probably more epidemiological evidence about soy than any other food because of the orientals' consumption of large amounts. There is no evidence of increased goiter in Orientals who eat 30 times the amount of soy we do! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 21, 2001 Report Share Posted November 21, 2001 - <dfnewman Tuesday, November 20, 2001 11:06 PM Soy > I personally have had some very unfortunate experiences with soy > and a medication that I have to take... Hi Donna, Care to discuss this? Are you getting enough iodine? ======================== Good Health & Long Life, Greg Watson, gowatson USDA database (food breakdown) http://www.nal.usda.gov/fnic/foodcomp/ PubMed (research papers) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi DWIDP (nutrient analysis) http://www.walford.com/dwdemo/dw2b63demo.exe KIM (omega analysis) http://ods.od.nih.gov/eicosanoids/KIM_Install.exe Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 21, 2001 Report Share Posted November 21, 2001 - " Morton Bodanis " <mortonmb Wednesday, November 21, 2001 10:19 AM Re: Soy > Morton Bodanis wrote: > > Because > inhibition of thyroid hormone synthesis can induce goiter and thyroid > neoplasia in rodents, delineation of anti-thyroid mechanisms for soy > isoflavones may be important for extrapolating goitrogenic hazards identified > in chronic rodent bioassays to humans consuming soy products. Hi Morton, So do as the Asians do and eat foods with soy which are iodine rich, such as sea fish & seaweed. The isoflavones in soy are VERY beneficial, just understand that if you eat heaps, you may need some balancing iodine. ======================== Good Health & Long Life, Greg Watson, gowatson USDA database (food breakdown) http://www.nal.usda.gov/fnic/foodcomp/ PubMed (research papers) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi DWIDP (nutrient analysis) http://www.walford.com/dwdemo/dw2b63demo.exe KIM (omega analysis) http://ods.od.nih.gov/eicosanoids/KIM_Install.exe Quote Link to comment Share on other sites More sharing options...
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