Guest guest Posted December 31, 2005 Report Share Posted December 31, 2005 Synopsis of research article on vaccines. http://pathogens.plosjournals.org/perlserv/?request=get-document & doi=10%2E1371%2Fjournal%2Eppat%2E0010036 Synopsis The development of protective vaccines against infectious diseases such as AIDS, SARS, and West Nile virus has become a societal priority but remains a scientific challenge. In recent years, the threat of bioterrorism agents such as anthrax and smallpox has heightened the need for the rapid development of effective new vaccines. One of the major stumbling blocks to the implementation of any vaccine is the toxic side effects on the vaccine candidate. For example, a significant number of doses of a new vaccine against smallpox have been commissioned, but approximately 20% of the individuals targeted to be inoculated will suffer toxicity due to vaccination. Furthermore, an additional difficulty in the production of vaccines is the creation of sufficient doses to vaccinate a large population. The authors have identified a novel approach that appears to address these issues. They demonstrate that the inclusion, in low doses of vaccines, of a normal component of the antigen-processing pathway, the transporter associated with antigen processing (TAP), confers protective immunity against lethal viral loads during viral challenges. This new paradigm is shown to be applicable to many viruses, including poxviruses, and could significantly advance the creation of new vaccines and improve those that already exist. ----------- If vaccines manufactured today "under strict safety regulations" are so toxic then we can well imagine what we, 40 to 50 year olds, have been administered during our times. Jagannath. “New opinions often appear first as jokes and fancies, then as blasphemies and treason, then as questions open to discussion, and finally as established truths.” – George Bernard Shaw. Shopping Find Great Deals on Holiday Gifts at Shopping Quote Link to comment Share on other sites More sharing options...
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