Omega 3 & Prostate cancer

[Guest guest]

Hi All,

 

Here are a few recent studies which suggest Omega 3 and it's derivative EPA are

of use in reducing both cancer incidents

& cancer growth through EPA modulation of the eicosanoid balance toward more of

the good guys and less AA in cellular

membranes.

 

I use ground flax seed as I'm not a big fan of flax oil. The KIM software also

helps to balance your diet to obtain a

good Omega 6 to Omega 3 ratio. I'm currently at about 35 % n-6 long in long

total which is very good with a total n-6

energy % of about 2.5 %.

 

Get KIM here:

http://ods.od.nih.gov/eicosanoids/KIM_Install.exe

 

Also checkout:

http://ods.od.nih.gov/eicosanoids/

FOOD CHOICES THAT BALANCE YOUR BODY'S EICOSANOIDS

 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

1403817 & dopt=Abstract

During 30 years of follow-up, men who ate no fish had a two-fold to three-fold

higher frequency of prostate cancer than

those who ate moderate or high amounts did. Our results suggest that fish

consumption could be associated with decreased

risk of prostate cancer.

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

1323387 & dopt=Abstract

We found that the essential fatty acids, linoleic acid (LA) and arachidonic acid

(AA), and the AA metabolite PGE(2)

stimulate tumor growth while oleic acid (OA) and the omega-3 fatty acid,

eicosapentaenoic acid (EPA) inhibited growth.

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

1061949 & dopt=Abstract

alpha-Linolenic acid was significantly lower when tumor extended to an

anatomical or surgical margin (p = 0.008). The

omega-3 and omega-3-to-omega-6 fatty acid ratios were 1.5 to 3.3-fold lower in

cases than in controls, reaching

borderline significance in nearly all comparisons (p = 0.052 to 0.097). [They

examined cancerous prostates after

surgical removal]

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

0667474 & dopt=Abstract

In the polyunsaturated fatty acids (PUFAs), we found that the omega-3 PUFAs

level was significantly decreased in patient

with BPH and PC and that the omega-6 PUFAs level was increased in PC only. The

ratio of omega-3/omega-6 PUFAs decreased

in the following order of normal, BPH, and PC. CONCLUSION: It was proposed that

the changed composition level of PUFAs

including omega-3 and omega-6 PUFAs have certain relationship with both

prostatic diseases. Therefore, the ratio of

omega-3/omega-6 PUFAs also may have an important association with the benign and

malignant status of prostatic disease.

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

0590211 & dopt=Abstract

Studies in animal models and recent observations in humans, however, have

provided evidence that a high intake of

omega-polyunsaturated fatty acids (PUFAs), stimulates several stages in the

development of mammary and colon cancer,

from an increase in oxidative DNA damage to effects on cell proliferation, free

estrogen levels to hormonal catabolism.

In contrast, fish oil-derived omega-3 fatty acids seem to prevent cancer by

influencing the activity of enzymes and

proteins related to intracellular signalling and, ultimately, cell

proliferation. In this commentary, current evidence

from experimental and human studies is summarized that implicates a high intake

of omega-6 PUFAs in cancer of the

breast, colon and, possibly, prostate and which indicates that omega-3 PUFAs and

monounsaturated fatty acids such as

oleic acid (omega-9) are protective.

========================

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

0576293 & dopt=Abstract

There is both epidemiologic and experimental evidence that the long-chain

omega-3 fatty acids (FAs), which occur at high

levels in some fish oils, exert protective effects against some common cancers,

notably those of breast, colon, and,

perhaps, prostate. Multiple mechanisms are involved in this chemopreventive

activity, including suppression of

neoplastic transformation, cell growth inhibition and enhanced apoptosis, and

antiangiogenicity; however,

 

a common feature of most of these biological effects is the inhibition of

eicosanoid production from omega-6 FA

precursors.

 

Several of the known risk factors for breast, and colon cancer may be favorably

modified by dietary omega-3 FA

supplementation, and the implementation of clinical chemoprevention trials is

now feasible.

========================

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=9\

349691 & dopt=Abstract

This review concludes that clinical intervention trials designed to reduce total

fat intake and increase the ratio of

omega-3 to omega-6 fatty acids in the diet should be targeted at groups at a

relatively high risk for breast or prostate

cancer, and also at postsurgically treated cancer patients with the objective of

preventing disease recurrence.

 

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Good Health & Long Life,

Greg Watson,

http://www.ozemail.com.au/~gowatson

gowatson