Gardasil: Polysorbate 80 and Histidine, a marriage of disaster.

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Polysorbate 80 and Histidine, a marriage of

disaster

Do you know how it is when you have a gut feeling that just

won't quit? It is like the itch you just cannot scratch that gets worse

with time. It is very annoying. Well, I was finally able to scratch that

itch and all my efforts have finally paid off.

I have been researching Polysorbate 80 for some time now because I had a

gut feeling that there is something to this chemical. I have been doing

the same for Histidine because Gardasil is the first vaccine that is

using this chemical. I knew that the addition of Histidine had something

to do with what we are seeing with Gardasil. Here are my

findings.

The Polysorbate 80 that is used in Gardasil is a product of Croda

Chemicals, Inc. This information I received from a reliable source. The

product names are Crills and Crillets. Here is a description of the

product. Polysorbate 80 is listed as Crillet 4 Super a clear yellow

liquid, (oil in water) O/W emulsifier and dispersant often used in

conjunction with the appropriate Crill. Good solubilising properties,

recommended in systems with unsaturated lipid components such as oleyl

alcohol and vegetable triglycerides

Sorbitan esters and their ethoxylates

Crills and Crillets are a range of mild nonionic

surfactants providing formulating benefits in a number of

personal care applications. Entirely vegetable-derived, Croda's Crills

and Crillets have long-standing food and pharmacopoeia approvals and a

safe history of use in cosmetic products.

Properties and functions

Crillets (Polysorbates) are excellent O/W emulsifiers, solubilisers,

wetting agents and dispersants. In emulsion systems they are commonly

used in combination with the corresponding Crill. Manipulation of the

Crill/Crillet ratio produces emulsifying systems of various HLB

(hydrophilic-lipophilic balance) values, allowing the emulsification of

many cosmetic ingredients.

Health and safety

The Crills and Crillets are well-established raw materials used in a

variety of applications. Certain sorbitan esters are accepted as food

additives in Europe. Sorbitan esters are included in the FDA Inactive

Ingredients guide. Polysorbates 60 and 80 are GRAS listed. (Generally

recognized as safe.)

 

http://www.chservice.ru/download/Crills%20and%20Crillets.pdf

I found all this to be very interesting in the development of a

vaccine. The reason being, that if you check out the Croda's website you

will find and Crill and Crillet are mainly used for personal items and

cosmetics. I understand that it is also mentioned that it can be used in

a variety of applications but I would think that they would mention

vaccines or pharmaceutical uses as well. But that is neither here nor

there.

What I want to bring to your attention is the fact that Polysorbate 80 is

a surfactant. This is very important to remember.

sur•fac•tant (sÉ™r-fak'tÉ™nt, sûr'fak'-) n.

A surface-active substance.

A substance composed of lipoprotein that is secreted by the

alveolar cells of the lung and serves to maintain the stability of

pulmonary tissue by reducing the surface tension of fluids that coat the

lung.

Etymology

The term surfactant is a blend of "surface active

agent." Surfactants are usually organic compounds that

are amphiphilic, meaning they contain both hydrophobic groups (their

"tails") and hydrophilic groups (their "heads").

Therefore, they are soluble in both organic solvents and water. The term

surfactant was coined by Antara Products in 1950

 

http://www.answers.com/topic/surfactant

My source also explained to me in layman's language what all this

means so I am going to impart that information to you. What this does is

helps to suspend chemicals or materials evenly in the product that it is

being used. In regards to a vaccine this helps to keep all the chemicals

and virus like particles evenly distributed. This way one syringe will

not have more chemicals and another will not have more virus like

particles. You have more uniformity in the vaccine which is very

important.

Another thing that I want to mention is that Polysorbate 80 is used in

other products, such as Epoetin alpha (Eprex ®) and Darbopoetin alpha

(Aranesp ®), which help stimulate the production of red blood cells in

people suffering from anemia caused by cancer treatment.

Now let me bring to you some information about Histidine. (I do not

endorse the product on this website.)

 

http://www.cfsn.com/histidine.html

I was looking for a good explanation of Histidine. Most of the

websites that I found were too technical and hard to understand. The

above website has an easy to understand definition and that is the only

reason that I am using it.

L-histidine* is an essential amino acid that cannot be formed

by other nutrients, and must be in the diet to be available to the

body.

Most often recognized as a precursor to the allergy symptom producing

hormone histamine, both histidine and histamine have essential roles in

the body beyond tormenting allergy sufferers.

Histamine is well known for its role in stimulating the inflammatory

response of skin and mucous membranes such as those found in the nose —

this action is essential in the protection of these barriers during

infection.

Histamine also stimulates the secretion of the digestive enzyme gastrin.

Without adequate histamine production healthy digestion can become

impaired. Without adequate L-histidine stores, the body cannot maintain

adequate histamine levels.

Less well known is that L-histidine is required by the body to regulate

and utilize essential trace minerals such as copper, zinc, iron,

manganese and molybdenum.

The addition of L-histidine in the vaccine Gardasil I believe was a

bad idea. Here are my thoughts. You have girls that are suffering after

receiving this vaccine and some of the symptoms are nausea, vomiting and

irritable bowel. Without adequate histamine production healthy

digestion can become impaired. This is the first clue in the

puzzle that is besieging these families and doctors that are trying to

deal with this new epidemic.

Another finding in the girls is that when a hair sample is tested they

are finding high levels of metals present. Less well known is that

L-histidine is required by the body to regulate and utilize essential

trace minerals... Some of the girl's symptoms are typical of

metal poisoning such as: nausea, vomiting, diarrhea, stomach pain,

headache, sweating...

 

 

http://www.healthatoz.com/healthatoz/Atoz/common/standard/transform.jsp?requestURI=/healthatoz/Atoz/ency/heavy_metal_poisoning.jsp

Use this site for a full description of Heavy Metal

Poisoning.

There is another thing that is predominate with the girls is joint pain.

I have found that low levels of histidine have been found in patients

with rheumatoid arthritis.

A study of sera from 285 patients with definite or classical

rheumatoid arthritis (including 37 patients receiving no

anti-inflammatory drugs) and sera from 67 healthy subjects has confirmed

10 published reports of a statistically significant decreased blood

histidine concentration in patients with rheumatoid arthritis.

 

 

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=301869

So what is happening here? It is my opinion that low levels of

histidine could be part of the overall problem that the girls are

experiencing. Now my question to the medical research community is what

could have caused this drop in histidine levels to cause all these

problems?

I have my theory and that is that the immune response that was produced

by the vaccine along with the infusion of histidine produced an

unexpected reaction in all the girls that have a family history of

allergies.

What happened is that because of this history it stands to reason that

these girls already had a higher than normal level of histidine/histamine

to begin with. Now we have just added more histidine into their systems

therefore overloading and creating a dangerous situation. The immune

system now has to deal with the dangerous levels of histidine along with

the virus like particles and aluminum. Now we have a programmed immune

response to the histidine and the immune system is going to attack

it.

Another thing that L-histidine does is that it can pass through the

placental wall to the fetus. This could be the direct cause to the

spontaneous miscarriage and birth defects in some of the babies. Here is

the MSDS (material safety data sheet) quote. Section 11: Toxicological

Information, Special Remarks on Chronic Effects on Humans: Passes through

the placental barrier in humans.

 

http://www.sciencelab.com/xMSDS-L_Histidine-9927189

Now this is where it gets interesting. I am going to tell you

about the marriage of Polysobate 80 a surfactant and

histidine. This is one marriage that was doomed to failure

from the start. Let me show you what I just found out a few days

ago.

 

 

http://www.anesthesiology.org/pt/re/anes/fulltext.00000542-200401000-00015.htm;jsessionid=LzQLy51JWy1VS2X8GtvFWGpKYnTHQ5gx9XxxB0jXv32cXFZPp37M!2126095447!181195629!8091!-1

 

The title of this report is Surfactants Attenuate

Gas Embolism-induced Thrombin Production.[1]

 

 

Background: There are no pharmacologic strategies to prevent

embolism bubble-induced blood clot formation. The authors conducted

experiments to measure thrombin production in sheared whole blood in the

presence and absence of bubbles and three surface-active

compounds.

 

 

 

 

 

 

Fig. 1. (A) Fluorescence emission spectrum of Boc-VPR-MCA in

the presence of thrombin. (B) Fluorescence emission spectrum of

Boc-VPR-MCA in a sample of whole blood sheared at 100 s-1 for various

durations. Excitation wavelength was 355 nm in all cases.

 

 

 

 

 

 

Fig. 2. (A) Continuous measurement of thrombin production

induced by addition of histamine to whole blood. • = whole blood; ∇ =

whole blood plus histamine. *P < 0.05 compared with the whole

blood group (n = 3 per group). (B) Continuous measurement of

platelet activation-mediated thrombin production induced by addition of

adenosine diphosphate (ADP) in the presence of the three study

surfactants. DCA = Dow Corning Antifoam 1510US; PF-127 = Pluronic

F-127.

 

I was not familiar with the term Thrombin so I looked it up on

MedicineNet.com.

 

http://www.medterms.com/script/main/art.asp?articlekey=5764

Definition of Thrombin

Thrombin: A key clot promoter, thrombin is an enzyme that

presides over the conversion of a substance called fibrinogen to fibrin,

the right stuff for a clot.

Now back to this report. I was shocked when I read this paragraph of

this report.

The time-dependent enhancement of thrombin production

presented in

 

figure 1B also appears in the data obtained

using quiescent whole blood samples with and without exposure to

histamine, as is depicted in

 

figure 2A. Only means ± SDs of the peak fluorescence

intensity data (emission wavelength, 460 nm) for each group at each time

point are shown. The level of blood activation increased slightly more

than 2-fold in the untreated quiescent sample after 30 min. In the

histamine-treated sample, thrombin production increased more than 5-fold

from the baseline value after 30 min. After the initial time

point, significantly more thrombin was formed in the histamine-activated

samples (P < 0.004 in all cases).

I want to make it perfectly clear that I am not a research scientist.

I just present the facts as I find them and you are to make your own

determination.

Now one of the things that we all know is that birth control pills can

cause blood clots and anyone that is taking them should be aware of that

fact. But were birth control pills the cause in some of the VAERS

reports? I am no longer sure of that.

Now let us put this together with what I just gave you about surfactants

and histamine you now have the possibility of a lethal, in my opinion,

reaction of blood clots. According to the data that I have it proves to

me that clotting does not necessarily happen because a girl is taking

birth control pills during the time she received the Gardasil

vaccination. This clotting has the real chance of happening because of

the surfactant and histamine reaction in the body. Not because of

the birth control.

I do not know how long it can take a blood clot to travel in the body.

Nor do I know if this is the cause to the blood clots but it is pretty

coincidental in my opinion. I think that Gardasil and this new

relationship should be studied further before any more girls die or have

a severe reaction to this vaccine.

One of the more severe side-effects that cannot be connected to the

Gardasil vaccine is the MS like symptoms that some of the girls are

experiencing. Doctors have not been able to find a cause to why this is

happening and they are stumped but keep on doing research.

Now, as I said earlier I am not a research scientist and I can only base

my opinion on what I know but I found something of great importance that

further proves the causative factor of the infusion of L-Histidine in

this vaccine.

I want to thank the Journal of Immunology for making the whole study

available to the public.

A Key Regulatory Role for Histamine in Experimental Autoimmune

Encephalomyelitis: Disease Exacerbation in Histidine

Decarboxylase-Deficient Mice [2]

 

http://www.jimmunol.org/cgi/content/full/176/1/17

In this study, we used HDC-deficient (HDC–/–) mice, which are

unable to synthesize histamine, to investigate the role of endogenous

histamine in the development and progression of EAE. We report in this

study that myelin oligodendrocyte glycoprotein- (MOG) 35–55-induced

chronic EAE is more severe in a setting of profound histamine

deficiency.

HDC — L-histidine decarboxylase

EAE — Experimental autoimmune encephalomyelitis

MOG — myelin oligodendrocyte glycoprotein

I read this whole study and it is hard to understand the procedures and

the different tests that they conducted to come up with their

conclusions. The one thing that I realized after reading it several times

is that if you are depleted in your histamine production you have a good

chance of having Encephalomyelitis symptoms which is an autoimmune

disease.

Now I know that many people do not like the fact that I reference

Wikipedia but I find it to be a good source of information especially

with the sources are cited so I am going to use it now.

Encephalomyelitis is a general term for inflammation of the brain

and spinal cord, describing a number of disorders:

acute disseminated encephalomyelitis or postinfectious

encephalomyelitis, a demyelinating disease of the brain and spinal

cord, possibly triggered by vaccination or viral

infection;[1][2]

encephalomyelitis disseminata, a synonym for multiple

sclerosis;

equine encephalomyelitis, a potentially fatal mosquito-borne

viral disease that infects horses and humans;

myalgic encephalomyelitis, a syndrome involving inflammation

of the central nervous system with symptoms of muscle pain and fatigue;

the term has sometimes been used interchangeably with chronic fatigue

syndrome, though there is still controversy over the

distinction.[3]

experimental autoimmune encephalomyelitis (EAE), an animal

model of brain inflammation.

[3]

 

^

 

Myalgic encephalomyelitis at NIH's Office of Rare

Diseases

I am bringing this one to your attention because of the symptoms noted

which are muscle pain and fatigue. The girls are experiencing these

symptoms along with many of the others that I have listed above. To

further prove my point I did a search on Myalgic Encephalomyelitis and

this is what I found.

 

http://www.cfs-news.org/me.htm

Onset [3]

Onset may be sudden and without apparent cause, for example a sudden

attack of acute vertigo. There is usually a history of infection of the

upper respiratory tract or, occasionally, the gastrointestinal tract. All

cases have low grade pyrexia (up to 38 deg. C) usually subsiding within a

week.

Subsequently, there is a persistent and profound fatigue, accompanied by

a medley of symptoms such as headache, giddiness and a number of muscle

symptoms such as pain, cramp, twitching, tenderness and weakness

(especially after exercise). Other symptoms include paraesthesia

(tingling, pricking, or numbness), frequency of micturition

(urination), blurred vision and/or diplopia (double vision),

hyperacusis (sometimes alternating with deafness or normal hearing)

tinnitus, fainting attacks which may be the result of hypoglycaemia and a

general sense of "feeling awful."

Another symptom that is common with this vaccine is seizures. I found

this study relevant to histidine/histamine.

 

http://lib.bioinfo.pl/pmid:15179676

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 May ;33:197-200

15179676 (P,S,E,B)

[Effect of alahistidine on brain histamine content and seizure

development]

Wei-wei Hu, Zhong Chen, Li-sha Xu, Chun-lei Jin, Eiko Sakurai,

Kazuhiko Yanai

OBJECTIVE: To investigate the effect of alahistidine on brain histamine

content and seizure development. METHODS: The kindling seizure was

induced by ip injection with subconvulsant dose of pentylenetetrazole

every 48 h. Monoamines and their metabolites were measured using a HPLC

system and fluorometric assay. RESULT: Chronic low histamine

feeding markedly decreased histamine content in cortex and hypothalamus,

and promoted seizure development induced by pentylenetetrazole.

However, alahistidine feed reversed the decreased histamine content and

slowed seizure development caused by low histamine feed. Both low

histamine and alahistidine feed had no effect on norepinephrine, dopamine

and its metabolites. CONCLUSION: Alahistidine may affect histaminergic

system and seizure development.

NOTE: I was not able to access the full study because a subscription

was needed.

Look at all this. I mean really look at this. We have the same symptoms

that the girls are going through. How much more can I give to prove that

we have the causative factor involved with this new epidemic we are

experiencing with this vaccine.

How long is it going to take the FDA and the CDC and all the other

organizations around the world to see what is happening here? We already

have 9,749 reported adverse events and 21 reported deaths in the United

States alone. Do we need to make that number go into the 100,000's? What

do they need?

I am begging the FDA, CDC and Merck to please please look at my findings.

I am not a research scientist but I was the one to have to put the pieces

of this epidemic together for you. Check out the dates of the studies

that I have referenced. This information was available pre-licensure of

Gardasil. Find out who was asleep at the switch to let all these findings

be ignored.

Why did I have to be the one? Why were not these chemicals studied in a

setting to see what they would do in a vaccine environment? WHY, WHY,

WHY!!!!!!!!! We have girls dying and disabled and you are saying that

there is no causative factor with Gardasil. Here it is! All the

causation you need. Look into this immediately.

Oh, my dear God. I am sorry but I have to end this article here because I

am next to tears and cannot go any further.

Please do your own research into this vaccine and decide if it is the

right thing for you.

NOTE: If I have made any mistakes because I am not a research scientist

with what I have posted here today please feel free to let me know and I

will check out your findings and post a retraction.

[1] Anesthesiology:Volume 100(1)January 2004pp 77-84

Surfactants Attenuate Gas Embolism-induced Thrombin

Production

[LABORATORY INVESTIGATIONS]

Eckmann, David M. Ph.D., M.D.*; Diamond, Scott L. Ph.D.†

* Associate Professor, Department of Anesthesia and the Institute for

Medicine and Engineering; † Professor, Department of Chemical Engineering

and the Institute for Medicine and Engineering.

Received from the Department of Anesthesia, University of Pennsylvania,

Philadelphia, Pennsylvania.

Submitted for publication June 16, 2003.

Accepted for publication August 25, 2003.

Supported by grant No. R01 HL-67986 from the National Heart, Lung and

Blood Institute, Bethesda, Maryland, and the Department of Anesthesia,

University of Pennsylvania.

Presented in part at the 4th World Congress of Biomechanics, Calgary,

Alberta, Canada, August 6, 2002.

Address reprint requests to Dr. Eckmann: Department of Anesthesia,

University of Pennsylvania, 3400 Spruce Street, Philadelphia,

Pennsylvania 19104. Address electronic mail to: eckmanndm.

Individual article reprints may be purchased through the Journal Web

site,

 

www.anesthesiology.org .

[2] The Journal of Immunology, 2006, 176: 17-26.

Copyright © 2006 by

The American

Association of Immunologists

A Key Regulatory Role for Histamine in Experimental Autoimmune

Encephalomyelitis: Disease Exacerbation in Histidine

Decarboxylase-Deficient

Mice

1

Silvia Musio*, Barbara Gallo*, Stefano Scabeni*, Marilena

Lapilla*, Pietro L. Poliani , Giuseppe Matarese , Hiroshi Ohtsu , Stephen

J. Galli¶,#, Renato Mantegazza*, Lawrence Steinman||,# and Rosetta

Pedotti

2,*

* Immunology and Muscular Pathology Unit, National Neurological

Institute "C. Besta," Milan, Italy; Department of Pathology,

University of Brescia Medical School, Brescia, Italy; Gruppo di

ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia

Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy; Applied

Quantum Medical Engineering, Graduate School of Engineering, Tohoku

University, Sendai, Japan; and ¶ Department of Pathology, || Department

of Neurology and Neurological Sciences, and # Interdepartmental Program

in Immunology, Stanford University, Stanford, CA 94305

Received for publication April 12, 2005. Accepted for publication August

2, 2005.

[3] A. Melvin Ramsay. Myalgic Encephalomyelitis and Postviral Fatigue

States: The Sage of Royal Free disease. 2nd edition. Gower Medical

Publishing, London 1988.

Note: this fair summary of Ramsay's 1988 description is taken from the

National Task Force

Report, 1994.

 

 

 

http://www.renewamerica.us/columns/janak/080830"It is now 30 years since I have been confining myself to the treatment ofchronic diseases. During those 30 years I have run against so many histories of littlechildren who had never seen a sick day until they were vaccinated and who, in the severalyears that have followed, have never seen a well day since. I couldn't put my finger onthe disease they have. They just weren't strong. Their resistance was gone. They wereperfectly well before they were vaccinated. They have never been well since. "---Dr. William Howard Hay

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