There's plenty yet that you didn't know about soy!

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Birth Defects

There's plenty yet that you didn't know about soy!

 

We at Soyonlineservice knew in 1993 that women who had been fed soy formulas in

the 1970's were infertile, miscarrying, or producing babies with defects such as

spina bifida, deformed legs and missing organs.

 

The risks of exposure to the quantities of estrogens in products being consumed

by pregnant women, and by infants, that were analysed by scientists consulted by

Soyonlineservice were obvious and were specifically drawn to the attention of

the US Food and Drug Administration, US EPA, the Australian National Food

Authority, the Australian CSIRO, ANZFA, the NZ Ministry of Health, Health

Canada, UK MAFF, UK Dept of Health , WHO and FAO/Codex.

 

ANZFA has even secretly assessed that soy estrogens pose health hazards to

foetal and neonatal development, to sexual maturation, and to sexual

differentiation (i.e. the ambiguity of sexual organs recited by the American

Endocrine Society http://www.emedicine.com/ped/topic1881.htm : See page 4 re soy

and ambiguous genitalia], and by the London Independent

http://www.independent.co.uk/story.jsp?story=275758.

 

All of those " Food Safety " agencies have failed to exercise the " Precautionary

Principle " of notifying women who innocently shop at supermarkets for soy foods

and infant formulas . Women do so without receiving the slightest Government

hint that there may be danger lurking for their babies.

 

A real worry is that birth defects like hypospadias and cryptorchidism are

external and visible in boys. Congenital abnormalities of the male genital tract

are also increasing, and once again soy phytoestrogens may be implicated,

according to a study that found a higher incidence of birth defects in male

offspring of vegetarian, soy-consuming mothers.

 

In girls the DES effects were internal and only showed up at adulthood. (see our

Soy and DES page). The Wingspread Statement also discusses birth defects from

DES etc. Follow these links Part 1 Part 2 to read more.

 

One should wonder at the " dark power " of an industry that can have such global

powers to suppress the basic legal rights of consumers everywhere.

 

Further Reading

 

Placental transfer of the soy isoflavone genistein following dietary and gavage

administration to Sprague Dawley rats.

 

Doerge DR, Churchwell MI, Chang HC, Newbold RR, Delclos KB. Reprod Toxicol 2001

Mar-Apr;15(2):105-10

 

Fetal brain contained predominately genistein aglycone at levels similar to

those in the maternal brain. These studies show that genistein aglycone crosses

the rat placenta and can reach fetal brain from maternal serum genistein levels

that are relevant to those observed in humans.

 

Full Abstract Here

 

Maternal exposure to genistein during pregnancy increases carcinogen-induced

mammary tumorigenesis in female rat offspring.

 

Hilakivi-Clarke L, Cho E, Onojafe I, Raygada M, Clarke R. Oncol Rep 1999

Sep-Oct;6(5):1089-95

 

The results indicate that in utero exposure to genistein, but not to

zearalenone, dose-dependently increased the incidence of DMBA-induced mammary

tumors, when compared with the controls.

 

Our results suggest that a maternal exposure to subcutaneous administration of

genistein can increase mammary tumorigenesis in the offspring, mimicking the

effects of in utero estrogenic exposures. Further, increased ER protein levels

and reduced PKC activity in the mammary gland may be involved in increasing

susceptibility to carcinogen-induced mammary tumorigenesis in rats exposed to

genistein in utero.

 

Full Abstract Here

 

p53, mutations, and apoptosis in genistein-exposed human lymphoblastoid cells.

 

Morris SM, Chen JJ, Domon OE, McGarrity LJ, Bishop ME, Manjanatha MG, Casciano

DA.Mutat Res 1998 Aug 31;405(1):41-56

 

Our results may be interpreted that genistein is a chromosomal mutagen

 

Full Abstract Here

 

Neurobehavioral actions of coumestrol and related isoflavonoids in rodents.

 

Whitten PL, Patisaul HB, Young LJ. Neurotoxicol Teratol 2002 Jan-Feb;24(1):47-54

 

Treatment of rat dams with a 100-ppm coumestrol diet from birth to postnatal day

(PND) 21 induced premature anovulation in female offspring, and treatment from

birth to PND 10 suppressed sexual behavior in male offspring.

 

Full Abstract Here

 

Cross-species and interassay comparisons of phytoestrogen action.

 

Whitten PL, Patisaul HB. Environ Health Perspect 2001 Mar;109 Suppl 1:5-20

 

In vivo data show that phytoestrogens have a wide range of biologic effects at

doses and plasma concentrations seen with normal human diets. Significant in

vivoresponses have been observed in animal and human tests for bone, breast,

ovary, pituitary, vasculature, prostate, and serum lipids. The doses reported to

be biologically active in humans (0.4--10 mg/kg body weight/day) are lower than

the doses generally reported to be active in rodents (10--100 mg/kg body

weight/day), although some studies have reported rodent responses at lower

doses.

 

Full Abstract Here

 

Effects of dietary genistein exposure during development on male and female CD

(Sprague-Dawley) rats.

 

Delclos KB, Bucci TJ, Lomax LG, Latendresse JR, Warbritton A, Weis CC, Newbold

RR. Reprod Toxicol 2001 Nov;15(6):647-63

 

Human exposure to genistein is predominantly through consumption of soy

products, including soy-based infant formula and dietary supplements.

 

Body weight and feed consumption of the treated dams prior to parturition showed

a decreasing trend with a significant reduction at the highest dose. Litter

birth weight was depressed in the 1250 ppm dose group, and pups of both sexes in

that dose group had significantly decreased body weights relative to controls at

the time of sacrifice. The most pronounced organ weight effects in the pups were

decreased ventral prostate weight in males at the 1250 ppm dose and a trend

toward higher pituitary gland to body weight ratios in both sexes.

Histopathologic examination of female pups revealed ductal/alveolar hyperplasia

of the mammary glands at 250 to 1250 ppm. Ductal/alveolar hyperplasia and

hypertrophy also occurred in males, with significant effects seen at 25 ppm and

above. Abnormal cellular maturation in the vagina was observed at 625 and 1250

ppm, and abnormal ovarian antral follicles were observed at 1250 ppm. In males,

aberrant or delayed spermatogenesis in the seminiferous tubules relative to

controls was observed at 1250 ppm. There was a deficit of sperm in the

epididymis at 625 and 1250 ppm relative to controls, although testicular

spermatid head counts and epididymal spermatozoa counts did not show significant

differences from controls at these doses. Both sexes showed an increase in the

incidence and/or severity of renal tubal mineralization at doses of 250 ppm and

above.

 

Dietary genistein thus produced effects in multiple estrogen-sensitive tissues

in males and females that are generally consistent with its estrogenic activity.

These effects occurred within exposure ranges achievable in humans.

 

Full Abstract Here

 

 

 

 

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