Jama Report on Soy

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Effects of Soy Protein with Isoflavones on Postmenopausal Women

 

This study proves what I have been saying all along: soy protein with

isoflavones supplements do not improve brain function, bone density or your

cholesterol levels, especially if you are 60 and above. Of course, you know

which market kept this study from reaching the eyes and ears of consumers.

 

JAMA. 2004 Jul 7;292(1):65-74.

 

 

Effect of soy protein containing isoflavones on cognitive function, bone

mineral density, and plasma lipids in postmenopausal women: a randomized

controlled trial.

 

Kreijkamp-Kaspers S, Kok L, Grobbee DE, de Haan EH, Aleman A, Lampe JW,

van der Schouw YT.

 

The Julius Center for Health Sciences and Primary Care, University

Medical Center Utrecht, The Netherlands.

 

CONTEXT: Postmenopausal estrogen therapy has been posited to have some

beneficial effects on aging processes, but its use has risks. Isoflavones,

estrogenlike compounds naturally occurring in plant foods, might confer

positive effects with fewer adverse effects. OBJECTIVE: To investigate

whether soy protein with isoflavones improves cognitive function, bone

mineral density, and plasma lipids in postmenopausal women. DESIGN, SETTING,

AND PARTICIPANTS: Double-blind, randomized, placebo-controlled trial of 202

healthy postmenopausal women aged 60 to 75 years, recruited from a

population-based sample in the Netherlands, conducted between April 2000 and

September 2001. INTERVENTION: Participants were randomly assigned to receive

25.6 g of soy protein containing 99 mg of isoflavones (52 mg genistein, 41

mg daidzein, and 6 mg glycetein or total milk protein as a powder on a daily

basis for 12 months. MAIN OUTCOME MEASURES: Cognitive function was assessed

using the following instruments: dementia, Mini-Mental State Examination;

memory, Rey Auditory Verbal Learning Test, immediate recall, delayed recall,

and recognition, the Digit Span forward and reversed, and the Doors test;

complex attention tasks, Digit Symbol Substitution and Trailmaking, A1, A2,

and B; and verbal skills, Verbal Fluency A and N, animals and occupations,

and the Boston Naming Task. Bone mineral density of the hip and lumbar spine

was assessed using dual-energy x-ray absorptiometry scanning. Lipid

assessment included lipoprotein(a), total cholesterol, low-density

lipoprotein, high-density lipoprotein, and triglycerides. RESULTS: A total

of 175 women completed the baseline and at least 1 postintervention analysis

and were included in the modified intent-to-treat analysis. Adherence was

good (median plasma genistein levels, 17.2 and 615.1 nmol/L for placebo and

soy group, respectively). Cognitive function, bone mineral density, or

plasma lipids did not differ significantly between the groups after a year.

 

CONCLUSION: This double-blind randomized trial does not support the

hypothesis that the use of soy protein supplement containing isoflavones

improves cognitive function, bone mineral density, or plasma lipids in

healthy postmenopausal women when started at the age of 60 years or later.

 

Publication Types:

 

* Clinical Trial

* Randomized Controlled Trial

 

 

PMID: 15238592 [PubMed - indexed for MEDLINE]

 

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