Guest guest Posted September 7, 2004 Report Share Posted September 7, 2004 Male infants undergo a "testosterone surge" during the first few months of life, when testosterone levels may be as high as those of an adult male. During this period, the infant is programmed to express male characteristics after puberty, not only in the development of his sexual organs and other masculine physical traits, but also in setting patterns in the brain characteristic of male behavior.In monkeys, deficiency of male hormones impairs the development of spatial perception (which, in humans, is normally more acute in men than in women), of learning ability and of visual discrimination tasks (such as would be required for reading).59 It goes without saying that future patterns of sexual orientation may also be influenced by the early hormonal environment. Male children exposed during gestation to diethylstilbestrol (DES), a synthetic estrogen that has effects on animals similar to those of phytoestrogens from soy, had testes smaller than normal on manturation.60Learning disabilities, especially in male children, have reached epidemic proportions. Soy infant feeding - which began in earnest in the early 1970s - cannot be ignored as a probable cause for these tragic developments.As for girls, an alarming number are entering puberty much earlier than normal, according to a recent study reported in the journal Pediatrics.61 Investigators found that one per cent of all girls now show signs of puberty, such as breast development or pubic hair, before the age of three; by age eight, 14.7 per cent of white girls and almost 50 per cent of African-American girls have one or both of these characteristics.New data indicate that environmental estrogens such as PCBs and DDE (a breakdown product of DDT) may cause early sexual development in girls.62 In the 1986 Puerto Rico Premature Thelarche study, the most significant dietary association with premature sexual development was not chicken - as reported in the press - but soy infant formula.63The consequences of this truncated childhood are tragic. Young girls with mature bodies must cope with feelings and urges that most children are not well-equipped to handle. And early maturation in girls is frequently a harbinger for problems with the reproductive system later in life, including failure to menstruate, infertility and breast cancer.Parents who have contacted the Jameses recount other problems associated with children of both sexes who were fed soy-based formula, including extreme emotional behavior, asthma, immune system problems, pituitary insufficiency, thyroid disorders and irritable bowel syndrome - the same endocrine and digestive havoc that afflicted the Jameses' parrots. Dissension In The Ranks Organizers of the Third International Soy Symposium would be hard-pressed to call the conference an unqualified success. On the second day of the symposium, the London-based Food Commission and the Weston A. Price Foundation of Washington, DC, held a joint press conference, in the same hotel as the symposium, to present concerns about soy infant formula.Industry representatives sat stony-faced through the recitation of potential dangers and a plea from concerned scientists and parents to pull soy-based infant formula from the market. Under pressure from the Jameses, the New Zealand Government had issued a health warning about soy infant formula in 1998; it was time for the American government to do the same.On the last day of the symposium, presentations on new findings related to toxicity sent a well-oxygenated chill through the giddy helium hype. Dr Lon White reported on a study of Japanese Americans living in Hawaii, that showed a significant statistical relationship between two or more servings of tofu a week and "accelerated brain aging".64 Those participants who consumed tofu in mid-life had lower cognitive function in late life and a greater incidence of Alzheimer's disease and dementia. "What's more," said Dr White, "those who ate a lot of tofu, by the time they were 75 or 80 looked five years older".65 White and his colleagues blamed the negative effects on isoflavones - a finding that supports an earlier study in which postmenopausal women with higher levels of circulating estrogen experienced greater cognitive decline.66Scientists Daniel Sheehan and Daniel Doerge, from the National Center for Toxicological Research, ruined PTI's day by presenting findings from rat feeding studies, indicating that genistein in soy foods causes irreversible damage to enzymes that synthesise thyroid hormones.67"The association between soybean consumption and goiter in animals and humans has a long history," wrote Dr Doerge. "Current evidence for the beneficial effects of soy requires a full understanding of potential adverse effects as well."Dr Claude Hughes reported that rats born to mothers that were fed genistein had decreased birth weights compared to controls, and onset of puberty occurred earlier in male offspring.68 His research suggested that the effects observed in rats "...will be at least somewhat predictive of what occurs in humans.There is no reason to assume that there will be gross malformations of fetuses but there may be subtle changes, such as neurobehavioral attributes, immune function and sex hormone levels." The results, he said, "could be nothing or could be something of great concern...if mom is eating something that can act like sex hormones, it is logical to wonder if that could change the baby's development".69A study of babies born to vegetarian mothers, published in January 2000, indicated just what those changes in baby's development might be. Mothers who ate a vegetarian diet during pregnancy had a fivefold greater risk of delivering a boy with hypospadias, a birth defect of the penis.70 The authors of the study suggested that the cause was greater exposure to phytoestrogens in soy foods popular with vegetarians.Problems with female offspring of vegetarian mothers are more likely to show up later in life. While soy's estrogenic effect is less than that of diethylstilbestrol (DES), the dose is likely to be higher because it's consumed as a food, not taken as a drug. Daughters of women who took DES during pregnancy suffered from infertility and cancer when they reached their twenties.____________________________ Question Marks Over GRAS Status Lurking in the background of industry hype for soy is the nagging question of whether it's even legal to add soy protein isolate to food. All food additives not in common use prior to 1958, including casein protein from milk, must have GRAS (Generally Recognized As Safe) status. In 1972, the Nixon administration directed a re-examination of substances believed to be GRAS, in the light of any scientific information then available.This re-examination included casein protein that became codified as GRAS in 1978. In 1974, the FDA obtained a literature review of soy protein because, as soy protein had not been used in food until 1959 and was not even in common use in the early 1970s, it was not eligible to have its GRAS status grandfathered under the provisions of the Food, Drug and Cosmetic Act.71The scientific literature up to 1974 recognized many antinutrients in factory-made soy protein, including trypsin inhibitors, phytic acid and genistein. But the FDA literature review dismissed discussion of adverse impacts, with the statement that it was important for "adequate processing" to remove them.Genistein could be removed with an alcohol wash, but it was an expensive procedure that processors avoided. Later studies determined that trypsin inhibitor content could be removed only with long periods of heat and pressure, but the FDA has imposed no requirements for manufacturers to do so.The FDA was more concerned with toxins formed during processing, specifically nitrites and lysinoalanine.72 Even at low levels of consumption - averaging one-third of a gram per day at the time - the presence of these carcinogens was considered too great a threat to public health to allow GRAS status.Soy protein did have approval for use as a binder in cardboard boxes, and this approval was allowed to continue, as researchers considered that migration of nitrites from the box into the food contents would be too small to constitute a cancer risk. FDA officials called for safety specifications and monitoring procedures before granting of GRAS status for food.These were never performed. To this day, use of soy protein is codified as GRAS only for this limited industrial use as a cardboard binder. This means that soy protein must be subject to premarket approval procedures each time manufacturers intend to use it as a food or add it to a food.Soy protein was introduced into infant formula in the early 1960s. It was a new product with no history of any use at all. As soy protein did not have GRAS status, premarket approval was required. This was not and still has not been granted. The key ingredient of soy infant formula is not recognized as safe. The Next Asbestos? "Against the backdrop of widespread praise...there is growing suspicion that soy - despite its undisputed benefits - may pose some health hazards," writes Marian Burros, a leading food writer for the New York Times. More than any other writer, Ms Burros's endorsement of a low-fat, largely vegetarian diet has herded Americans into supermarket aisles featuring soy foods.Yet her January 26, 2000 article, "Doubts Cloud Rosy News on Soy", contains the following alarming statement: "Not one of the 18 scientists interviewed for this column was willing to say that taking isoflavones was risk free." Ms Burros did not enumerate the risks, nor did she mention that the recommended 25 daily grams of soy protein contain enough isoflavones to cause problems in sensitive individuals, but it was evident that the industry had recognized the need to cover itself.Because the industry is extremely exposed...contingency lawyers will soon discover that the number of potential plaintiffs can be counted in the millions and the pockets are very, very deep. Juries will hear something like the following: "The industry has known for years that soy contains many toxins.At first they told the public that the toxins were removed by processing. When it became apparent that processing could not get rid of them, they claimed that these substances were beneficial. Your government granted a health claim to a substance that is poisonous, and the industry lied to the public to sell more soy."The "industry" includes merchants, manufacturers, scientists, publicists, bureaucrats, former bond financiers, food writers, vitamin companies and retail stores. Farmers will probably escape because they were duped like the rest of us. But they need to find something else to grow before the soy bubble bursts and the market collapses: grass-fed livestock, designer vegetables...or hemp to make paper for thousands and thousands of legal briefs. Extracted from Nexus Magazine, Volume 7, Number 3 (April-May 2000) About the Authors: Sally Fallon is the author of Nourishing Traditions: The Cookbook that Challenges Politically Correct Nutrition and the Diet Dictocrats (1999, 2nd edition, New Trends Publishing, tel +1 877 707 1776 or +1 219 268 2601) and President of the Weston A. Price Foundation, Washington, DC (www.WestonAPrice.org) Mary G. Enig, Ph.D., a nutritionist widely known for her research on the nutritional aspects of fats and oils, is a consultant, clinician, and the Director of the Nutritional Sciences Division of Enig Associates, Inc., Silver Spring, Maryland. She received her PhD in Nutritional Sciences from the University of Maryland, College Park in 1984, taught a graduate course in nutrient-drug interactions for the University's Graduate Program in Nutritional Sciences, and held a Faculty Research Associateship from 1984 through 1991 with the Lipids Research Group in the Department of Chemistry and Biochemistry. Dr. Enig is a Fellow of the American College of Nutrition, and a member of the American Institute of Nutrition. Her many years of experience as a "bench chemist" in the analysis of food fats and oils, provides a foundation for her active roles in food labeling and composition issues at the federal and state levels.Dr. Enig is a Consulting Editor to the "Journal of the American College of Nutrition" and formerly served as a Contributing Editor to "Clinical Nutrition." She has published 14 scientific papers on the subject of food fats and oils, several chapters on nutrition for books, and presented over 35 scientific papers on food and nutrition topics. She is the President of the Maryland Nutritionists Association, past President of the Coalition of Nutritionists of Maryland and was appointed by the Governor in 1986 to the Maryland State Advisory Council on Nutrition and served as the Chairman of the Health Subcommittee until the Council was disbanded in 1988. COMMENT: Sally Fallon and Dr. Enig are to be highly commended for this much needed soy update. Together they have compiled the most definitive document to date on why one should avoid soy. This is a MAJOR work and I am hoping to promote it for the national media attention that it deserves. Another article on How Much Soy Asians Actually Eat http://www.mercola.com/2000/jan/9/truth_about_soy.htm ENDNOTES:1. Program for the Third International Symposium on the Role of Soy in Preventing and Treating Chronic Disease, Sunday, October 31, through Wednesday, November 3, 1999, Omni Shoreham Hotel, Washington, DC. 2. Houghton, Dean, "Healthful Harvest", The Furrow, January 2000, pp. 10-13. 3. Coleman, Richard J., "Vegetable Protein - A Delayed Birth?" Journal of the American Oil Chemists' Society 52:238A, April 1975. 4. See www/unitedsoybean.org. 5. These are listed in www.soyonlineservice.co.nz. 6. Wall Street Journal, October 27, 1995. 7. Smith, James F., "Healthier tortillas could lead to healthier Mexico", Denver Post, August 22, 1999, p. 26A. 8. "Bakery says new loaf can help reduce hot flushes", Reuters, September 15, 1997. 9. "Beefing Up Burgers with Soy Products at School", Nutrition Week, Community Nutrition Institute, Washington, DC, June 5, 1998, p. 2. 10. Urquhart, John, "A Health Food Hits Big Time", Wall Street Journal, August 3, 1999, p. B1 11. "Soyabean Milk Plant in Kenya", Africa News Service, September 1998. 12. Simoons, Frederick J., Food in China: A Cultural and Historical Inquiry, CRC Press, Boca Raton, 1991, p. 64. 13. Katz, Solomon H., "Food and Biocultural Evolution: A Model for the Investigation of Modern Nutritional Problems", Nutritional Anthropology, Alan R. Liss Inc., 1987, p. 50. 14. Rackis, Joseph J. et al., "The USDA trypsin inhibitor study. I. Background, objectives and procedural details", Qualification of Plant Foods in Human Nutrition, vol. 35, 1985. 15. Van Rensburg et al., "Nutritional status of African populations predisposed to esophageal cancer", Nutrition and Cancer, vol. 4, 1983, pp. 206-216; Moser, P.B. et al., "Copper, iron, zinc and selenium dietary intake and status of Nepalese lactating women and their breastfed infants", American Journal of Clinical Nutrition 47:729-734, April 1988; Harland, B.F. et al., "Nutritional status and phytate: zinc and phytate X calcium: zinc dietary molar ratios of lacto-ovovegetarian Trappist monks: 10 years later", Journal of the American Dietetic Association 88:1562-1566, December 1988. 16. El Tiney, A.H., "Proximate Composition and Mineral and Phytate Contents of Legumes Grown in Sudan", Journal of Food Composition and Analysis (1989) 2:6778. 17. Ologhobo, A.D. et al., "Distribution of phosphorus and phytate in some Nigerian varieties of legumes and some effects of processing", Journal of Food Science 49(1):199-201, January/February 1984. 18. Sandstrom, B. et al., "Effect of protein level and protein source on zinc absorption in humans", Journal of Nutrition 119(1):48-53, January 1989; Tait, Susan et al., "The availability of minerals in food, with particular reference to iron", Journal of Research in Society and Health 103(2):74-77, April 1983. 19. Phytate reduction of zinc absorption has been demonstrated in numerous studies. These results are summarised in Leviton, Richard, Tofu, Tempeh, Miso and Other Soyfoods: The 'Food of the Future' - How to Enjoy Its Spectacular Health Benefits, Keats Publishing, Inc., New Canaan, CT, USA, 1982, p. 1415. 20. Mellanby, Edward, "Experimental rickets: The effect of cereals and their interaction with other factors of diet and environment in producing rickets", Journal of the Medical Research Council 93:265, March 1925; Wills, M.R. et al., "Phytic Acid and Nutritional Rickets in Immigrants", The Lancet, April 8,1972, pp. 771-773. 21. Rackis et al., ibid. 22. Rackis et al., ibid., p. 232. 23. Wallace, G.M., "Studies on the Processing and Properties of Soymilk", Journal of Science and Food Agriculture 22:526-535, October 1971. 24. Rackis, et al., ibid., p. 22; "Evaluation of the Health Aspects of Soy Protein Isolates as Food Ingredients", prepared for FDA by Life Sciences Research Office, Federation of American Societies for Experimental Biology (9650 Rockville Pike, Bethesda, MD 20014), USA, Contract No. FDA 223-75-2004, 1979. 25. See www/truthinlabeling.org. 26. Rackis, Joseph, J., "Biological and Physiological Factors in Soybeans", Journal of the American Oil Chemists' Society 51:161A-170A, January 1974. 27. Rackis, Joseph J. et al., "The USDA trypsin inhibitor study", ibid. 28. Torum, Benjamin, "Nutritional Quality of Soybean Protein Isolates: Studies in Children of Preschool Age", in Soy Protein and Human Nutrition, Harold L Wilcke et al. (eds), Academic Press, New York, 1979. 29. Zreik, Marwin, CCN, "The Great Soy Protein Awakening", Total Health 32(1), February 2000. 30. IEH Assessment on Phytoestrogens in the Human Diet, Final Report to the Ministry of Agriculture, Fisheries and Food, UK, November 1997, p. 11. 31. Food Labeling: Health Claims: Soy Protein and Coronary Heart Disease, Food and Drug Administration 21 CFR, Part 101 (Docket No. 98P-0683). 32. Sheegan, Daniel M. and Daniel R Doerge, Letter to Dockets Management Branch (HFA-305), February 18, 1999. 33. Anderson, James W. et al., "Meta-analysis of the Effects of Soy Protein Intake on Serum Lipids", New England Journal of Medicine (1995) 333:(5):276-282. 34. Guy, Camille, "Doctors warned against magic, quackery", New Zealand Herald, September 9, 1995, section 8, p. 5. 35. Sander, Kate and Hilary Wilson, "FDA approves new health claim for soy, but litte fallout expected for dairy", Cheese Market News, October 22, 1999, p. 24. 36. Enig, Mary G. and Sally Fallon, "The Oiling of America", NEXUS Magazine, December 1998-January 1999 and February-March 1999; also available at www.WestonAPrice.org. 37. Natural Medicine News (L & H Vitamins, 32-33 47th Avenue, Long Island City, NY 11101), USA, January/February 2000, p. 8. 38. Harras, Angela (ed.), Cancer Rates and Risks, National Institutes of Health, National Cancer Institute, 1996, 4th edition. 39. Searle, Charles E. (ed.), Chemical Carcinogens, ACS Monograph 173, American Chemical Society, Washington, DC, 1976. 40. Nagata, C. et al., Journal of Nutrition (1998) 128:209-213. 41. Campbell, Colin T. et al., The Cornell Project in China. 42. Chang, K.C. (ed.), Food in Chinese Culture: Anthropological and Historical Perspectives, New Haven, 1977. 43. Messina, Mark J. et al., "Soy Intake and Cancer Risk: A Review of the In Vitro and In Vivo Data", Nutrition and Cancer (1994) 21(2):113-131. 44. Rackis et al, "The USDA trypsin inhibitor study", ibid. 45. Petrakis, N.L. et al., "Stimulatory influence of soy protein isolate on breast secretion in pre- and post-menopausal women", Cancer Epid. Bio. Prev. (1996) 5:785-794. 46. Dees, C. et al., "Dietary estrogens stimulate human breast cells to enter the cell cycle", Environmental Health Perspectives (1997) 105(Suppl. 3):633-636. 47. Woodhams, D.J., "Phytoestrogens and parrots: The anatomy of an investigation", Proceedings of the Nutrition Society of New Zealand (1995) 20:22-30. 48. Matrone, G. et al., "Effect of Genistin on Growth and Development of the Male Mouse", Journal of Nutrition (1956) 235-240. 49. Ishizuki, Y. et al., "The effects on the thyroid gland of soybeans administered experimentally in healthy subjects", Nippon Naibunpi Gakkai Zasshi (1991) 767:622-629. 50. Divi, R.L. et al., "Anti-thyroid isoflavones from the soybean", Biochemical Pharmacology (1997) 54:1087-1096. 51. Cassidy, A. et al., "Biological Effects of a Diet of Soy Protein Rich in Isoflavones on the Menstrual Cycle of Premenopausal Women", American Journal of Clinical Nutrition (1994) 60:333-340. 52. Murphy, P.A., "Phytoestrogen Content of Processed Soybean Foods", Food Technology, January 1982, pp. 60-64. 53. Bulletin de L'Office Fédéral de la Santé Publique, no. 28, July 20, 1992. 54. Keung, W.M., "Dietary oestrogenic isoflavones are potent inhibitors of B-hydroxysteroid dehydrogenase of P. testosteronii", Biochemical and Biophysical Research Committee (1995) 215:1137-1144; Makela, S.I. et al., "Estrogen-specific 12 B-hydroxysteroid oxidoreductase type 1 (E.C. 1.1.1.62) as a possible target for the action of phytoestrogens", PSEBM (1995) 208:51-59. 55. Setchell, K.D.R. et al., "Dietary oestrogens - a probable cause of infertility and liver disease in captive cheetahs", Gastroenterology (1987) 93:225-233; Leopald, A.S., "Phytoestrogens: Adverse effects on reproduction in California Quail," Science (1976) 191:98-100; Drane, H.M. et al., "Oestrogenic activity of soya-bean products", Food, Cosmetics and Technology (1980) 18:425-427; Kimura, S. et al., "Development of malignant goiter by defatted soybean with iodine-free diet in rats", Gann. (1976) 67:763-765; Pelissero, C. et al., "Oestrogenic effect of dietary soybean meal on vitellogenesis in cultured Siberian Sturgeon Acipenser baeri", Gen. Comp. End. (1991) 83:447-457; Braden et al., "The oestrogenic activity and metabolism of certain isoflavones in sheep", Australian J. Agricultural Research (1967) 18:335-348. 56. Ginsburg, Jean and Giordana M. Prelevic, "Is there a proven place for phytoestrogens in the menopause?", Climacteric (1999) 2:75-78. 57. Setchell, K.D. et al., "Isoflavone content of infant formulas and the metabolic fate of these early phytoestrogens in early life", American Journal of Clinical Nutrition, December 1998 Supplement, 1453S-1461S. 58. Irvine, C. et al., "The Potential Adverse Effects of Soybean Phytoestrogens in Infant Feeding", New Zealand Medical Journal May 24, 1995, p. 318. 59. Hagger, C. and J. Bachevalier, "Visual habit formation in 3-month-old monkeys (Macaca mulatta): reversal of sex difference following neonatal manipulations of androgen", Behavior and Brain Research (1991) 45:57-63. 60. Ross, R.K. et al., "Effect of in-utero exposure to diethylstilbestrol on age at onset of puberty and on post-pubertal hormone levels in boys", Canadian Medical Association Journal 128(10):1197-8, May 15, 1983. 61. Herman-Giddens, Marcia E. et al., "Secondary Sexual Characteristics and Menses in Young Girls Seen in Office Practice: A Study from the Pediatric Research in Office Settings Network", Pediatrics 99(4):505-512, April 1997. 62. Rachel's Environment & Health Weekly 263, "The Wingspread Statement", Part 1, December 11, 1991; Colborn, Theo, Dianne Dumanoski and John Peterson Myers, Our Stolen Future, Little, Brown & Company, London, 1996. 63. Freni-Titulaer, L.W., "Premature Thelarch in Puerto Rico: A search for environmental factors", American Journal of Diseases of Children 140(12):1263-1267, December 1986. 64. White, Lon, "Association of High Midlife Tofu Consumption with Accelerated Brain Aging", Plenary Session #8: Cognitive Function, The Third International Soy Symposium, November 1999, Program, p. 26. 65. Altonn, Helen, "Too much tofu induces 'brain aging', study shows", Honolulu Star-Bulletin, November 19, 1999. 66. Journal of the American Geriatric Society (1998) 46:816-21. 67. Doerge, Daniel R., "Inactivation of Thyroid Peroxidase by Genistein and Daidzein in Vitro and in Vivo; Mechanism for Anti-Thyroid Activity of Soy", presented at the November 1999 Soy Symposium in Washington, DC, National Center for Toxicological Research, Jefferson, AR 72029, USA. 68. Hughes, Claude, Center for Women's Health and Department of Obstetrics & Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA. 69. Soy Intake May Affect Fetus", Reuters News Service, November 5, 1999. 70. "Vegetarian diet in pregnancy linked to birth defect", BJU International 85:107-113, January 2000. 71. FDA ref 72/104, Report FDABF GRAS - 258. 72. "Evaluation of the Health Aspects of Soy Protein Isolates as Food Ingredients", prepared for FDA by Life Sciences Research Office, Federation of American Societies for Experimental Biology (FASEB) (9650 Rockville Pike, Bethesda, MD 20014, USA), Contract No, FDA 223-75-2004, 1979. Quote Link to comment Share on other sites More sharing options...
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