Abstract about the role of melatonin on low-denisity liporotein

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dorotheekrienJust found this abstract about the role of melatonin on low-denisity liporotein (LSL). Another important factor is electromagnetic radiation e.g microwave radiation from cell phones and towers. It reduces the production of melatonin drastically. Check: Cardiac Effects of Natural and Artificial EMRFolia Biol (Praha). 2009;55(2):45-52.

Oxidized-LDL and Fe3+/ascorbic acid-induced oxidative modifications and phosphatidylserine exposure in human platelets are reduced by melatonin.

Sener A, Ozsavci D, Bingol-Ozakpinar O, Cevik O, Yanikkaya-Demirel G, Yardimci T.

Department of Biochemistry, Faculty of Pharmacy, Marmara University, Istanbul, Turkey. azizesenerLow-density lipoprotein (LDL) modifications and platelet activation are major risk factors for cardiovascular diseases. When platelets are exposed to oxidative stress, they become activated. Oxidized LDL (ox-LDL) and metal-catalysed oxidation systems such as Fe3+/ascorbic acid increase free radical production. We wanted to verify whether melatonin has a protective effect against oxidative modifications and phosphatidylserine externalization in platelets induced by ox-LDL and Fe3+/ascorbic acid. For in vitro effects of melatonin on platelets, ADP-activated platelets were incubated with ox-LDL or Fe3+/ascorbic acid for 1 h at 37 degrees C with or without melatonin. Then platelet malondialdehyde, protein carbonyl and glutathione levels were measured. Platelet phosphatidylserine exposure was measured with annexin-V using flow cytometry. Malondialdehyde, protein carbonyl and phosphatidylserine levels of platelets treated with Fe3+/ascorbic acid significantly increased compared to the control group. Glutathione contents of Fe3+/ascorbic acid-treated platelets significantly decreased. Melatonin pre-treatment of Fe3+/ascorbic acid-treated platelets caused a mar ked reduction in malondialdehyde and phosphatidylserine levels and a marked increase in glutathione levels. Melatonin also caused non-significant reduction in protein carbonyl contents of Fe3+/ascorbic acid-treated platelets. Malondialdehyde, protein carbonyl and phosphatidylserine levels of platelets treated with ox-LDL also significantly increased compared to the control group. Platelet glutathione levels non-significantly decreased with ox-LDL. With addition of melatonin, malondialdehyde, protein carbonyl and phosphatidylserine levels of platelets treated with ox-LDL significantly decreased. These data suggest that melatonin may protect platelets from iron overload-induced and ox-LDL-induced oxidative modifications and also from the triggering signals of apoptosis activation, possibly due to its scavenger effect on toxic free radicalsPMID: 19454178 [PubMed - indexed for MEDLINE]http://www.ncbi.nlm.nih.gov/pubmed/19454178

On Sat, Sep 5, 2009 at 7:36 AM, M.M. <medresearch121 wrote:

 

 

 

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