Antidepressant aggression concern

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Antidepressant aggression concern

 

http://news.bbc.co.uk/1/hi/health/3675878.stm

 

Antidepressant drugs, such as Seroxat, could make people aggressive,

or even homicidal, a leading specialist has warned.

 

Dr David Healy, a North Wales psychologist, has previously raised

concerns over suicide risk linked to the class of drugs, known as

SSRIs.

 

He is now warning that even healthy people have become unaccountably

aggressive in studies into the drugs.

 

But drug companies say there is no increased risk linked to SSRIs.

 

These drugs can be really excellent for people, but it may be they

are not suitable for some says Dr David Healy, Cardiff University.

 

Dr Healy, director of Cardiff University's North Wales department of

psychological medicine at has previously warned SSRIs (selective

serotonin reuptake inhibitors) could be linked to an increased risk

of suicide.

 

Last year, the Department of Health said no SSRIs, except for

Prozac, should be given to under 18s after a review by medical

experts which looked at the safety of SSRIs after concerns over

suicide risk.

 

The Expert Working Group on SSRIs is now looking at data on adult

use of the drugs.

 

'No ban'

 

Dr Healy said research had also shown that even some healthy

volunteers who took part in trials of SSRIs became " hostile " , a

clinical term which can include serious aggression and even homicidal

behaviour.

 

He highlighted one trial of Seroxat in the late 1980s and early

1990s which found three out of 271 healthy volunteers became hostile,

compared to none of those who were taking the dummy pill.

 

He says while this only equals around 1.1%, it could translate to a

large number of cases among those taking the drug worldwide.

 

Dr Healy said other research had also raised concerns about

increased aggression in children on SSRIs.

 

He told BBC News Online: " I'm not saying these drugs should be

banned, but people should be warned about these risks when they are

put on these pills.

 

" These drugs can be really excellent for people, but it may be they

are not suitable for some.

 

" People taking SSRIs, and their families, should be told about the

kind of things to look out for during the first few weeks they are on

the drugs. "

 

But a spokesman for GlaxoSmithKine which makes Seroxat, said:

" Despite what Dr Healy suggests, there is no compelling evidence from

our clinical trials that Seroxat causes hostile behaviour in adults.

 

" When you put the results from all the clinical trials together

there is no difference between the rates of hostility for adult

patients taking Seroxat and the patients taking dummy pills. This

data has been shared with regulators. "

 

He added: " Dr Healy refers to three incidents of hostility or

aggressive reaction among participants taking Seroxat in a study

including healthy adult volunteers. Each of these incidents was

defined by the researchers as either a mild or moderate aggressive

reaction. These reactions resolved themselves without further

incident.

 

A spokeswoman for the Medicines Healthcare products Regulatory

Authority, which is advised by the Expert Working Group, said it

issued its guidance suggesting children should not be given most

SSRIs because of the clinical trial data in children which showed an

increased rate of a number of harmful outcomes including hostility.

 

She added: " The review of adult data is ongoing. "

 

 

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