Vitamin E status, role in depression?

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Vitamin E status, role in depression?

(Ed. of course they probably could find many nutritional diffiencies

in deppresed people.)

 

03/02/2005 - People with depression appear to have lower levels of

the vitamin E alpha-tocopherol circulating in their bloodstream,

report researchers, who will investigate further whether vitamin E

supplements can help their symptoms.

 

Levels of vitamin E have been reported to be lower in patients

suffering major depression but it was not known whether this is due to

inadequate dietary intake or a result of depression.

 

An Australian team measured plasma alpha-tocopherol levels in 49

adults with major depression, and also looked at usual dietary intake

of vitamin E by investigating diet history in a subset of the group.

 

This was designed to check whether these subjects had a lower dietary

intake of the vitamin than healthy people.

 

Diet analysis indicated that 89 per cent of subjects met or exceeded

the recommended intake for vitamin E, and so dietary intake was

unlikely to be responsible for the low alpha-tocopherol levels, write

the researchers in this month's European Journal of Clinical Nutrition

(vol 59, pp304-306).

 

Yet they found that the subjects had significantly lower levels of the

vitamin than has previously been reported for healthy Australians.

 

In addition, alpha-tocopherol levels were inversely related to

depression score.

 

" While it cannot be determined from our study, it seems possible that

the lower vitamin E in blood may be a marker of increased

physiological stress (possibly increased oxidative stress) in

depression, " lead author Dr Alice Owen from the Smart Foods Centre in

the University of Wollongong, Australia told NutraIngredients.com.

 

Previous studies have shown that antioxidant vitamins may protect the

brain against damage caused by free radicals and other reactive oxygen

species produced during basic cellular metabolism.

 

" We hope to see further research examining the role of oxidative

stress in the pathophysiology of depression, which will hopefully

allow the scientific community to develop new treatment strategies, "

added Dr Owen.

 

She noted however that there is no evidence so far to suggest that

increasing vitamin E status through supplements will be of therapeutic

value.

 

Owen's team will shortly release results from further research looking

at the effect of a nutritional supplement in adults with major depression.