Grape seed proanthocyanidin extract demonstrates better antioxidant activity than other free radical scavengers

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Grape seed proanthocyanidin extract demonstrates better antioxidant activity

than other free radical scavengers

http://herbs.org/current/grapeproanth.html

 

Proanthocyanidins are naturally occurring polyphenolic bioflavonoids in many

fruits and vegetables. They have been reported to have antiviral, antibacterial,

anti-inflammatory and antiallergic activities. These compounds may also protect

against oxidative damage of tissue by free radicals.

 

One source of these antioxidants is grape seed proanthocyanidin extract (GSPE).

In this laboratory study, GSPE demonstrated significant antioxidant activity in

liver and brain tissue, compared to controls.

 

GSPE was shown to decrease chemically-induced DNA damage, lipid peroxidation,

and production of oxygen free radicals.

 

It also provided better protection against oxidative damage than the same doses

of other antioxidants, including vitamin C, vitamin E succinate, and b-carotene.

From the results of these in vivo studies, GSPE appears to be better at

scavenging free radicals and preventing oxidative damage to brain and liver

tissue than other antioxidants.

 

Results also show that GSPE is available to target tissues and, therefore, can

be useful in vivo in inhibiting oxidative damage to brain and liver tissue.

 

 

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Bagchi D, Garg D, Krohn R, et al. Protective effects of grape seed

proanthocyanidins and selected antioxidants against TPA-induced hepatic and

brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage

activation in mice. Gen Pharmac 1998; 30(5):771-776.

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