Kd papers

[Guest guest]

1: Zhongguo Zhong Xi Yi Jie He Za Zhi 1996 Sep;16(9):515-

 

[Clinical observation on treatment of hyperinsulinemia and hyperandrogenism

anovulatory patient with replenishing kidney-yin drugs]

[Article in Chinese]

Zhou LR, Yu J.

The Obstetrics and Gynecology Hospital, Shanghai Medical University.

 

In order to investigate the effect of Chinese herbal medicine for

replenishing Kidney-Yin in treating hyperinsulinemia and hyperandrogenism

anovulatory syndrome, 35 patients were treated with replenishing Kidney-Yin

drugs for 3 months, basic body temperature, ultrasonic examination and blood

levels of sex hormones were taken for monitoring the ovulation, and changes

of serum insulin, blood sugar as well as oral glucose tolerence test were

observed before and after treatment. Thirty-five patients showed high serum

insulin and testosterone levels but normal dehydroepiandrosterone (DHEA)

level. Twenty-nine percent of their luteinizing hormone/folliclestimulating

hormone (LH/FSH) ratio were in normal range. Twenty four cases completed the

regular treatment and 20 of them showed ovulation in the 43 menstrual cycles

(59.7%). Seven of 17 (41.2%) infertile cases become pregnant within 6

months. After 3 months of treatment, blood sugar and insulin level

significantly decreased but the latter was still slightly higher than normal

level. Serum testosterone level decreased significantly and reached normal.

Results suggested that replenishing Kidney-Yin Drugs could provide a good

microcircumstance for ovarian follicular growth, and resulted in ovulation

and pregnancy. The mechanism is remained to be further explored.

 

PMID: 9772595 [PubMed - indexed for MEDLINE]

 

: Zhongguo Zhong Xi Yi Jie He Za Zhi 2002 Jan;22(1):33-6 Related Articles,

Links

 

[Exploration on essence of spleen-kidney deficiency in middle-aged patients]

[Article in Chinese]

Lin BH, Fang SQ, Ye Y.

Fujian Academy of TCM, Fuzhou 350003.

 

OBJECTIVE: To explore the essence of Spleen-Kidney Deficiency in middle-aged

patients. METHODS: Investigation was carried out in 773 cases of 50-69 years

old to assay 34 parameters in them, including blood lipid, oxidation and

anti-oxidation related substance, sex hormone, liver and renal function,

immune function, blood routine, blood pressure and lung vital capacity, etc.

RESULTS: Spleen Deficiency Syndrome is closely related with lipid metabolism

disorder; Kidney-Qi Deficiency Syndrome is closely related with hypoimmune

function; Kidney-Yin Deficiency Syndrome is closely related with lipid

metabolism disorder and hypertension, and Kidney Yang Deficiency is closely

related with weakness of anti-oxidation capacity, hypoimmunity, the internal

environment disorder of sex hormone and aging, manifested as multiple

functions abating. CONCLUSION: Spleen Deficiency, Kidney-Qi Deficiency and

Kidney Yang Deficiency are different layers of a gradually developed and

aggravated pathological process, but Kidney-Yin Deficiency could not be

listed into this layer.

 

PMID: 12585169 [PubMed - in process]

 

1: Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Jul;19(7):415-7. Related

Articles, Links

 

 

[Effect of regulation of kidney-yin and kidney-yang on

hypothalamus-pituitary-adrenal-thymus axis in monosodium L-glutamate rats]

[Article in Chinese]

Cai D, Chen X, Liu Y.

Institute of Integrated Traditional and Western Medicine, Shanghai Medical

University, Shanghai (200040).

 

OBJECTIVE: To study the interrelationship between

hypothalamus-pituitary-adrenal-thymus (HPAT) axis and Kidney-Yang and

Kidney-Yin in arcuate nucleus destroyed rats. METHODS: Monosodium

glutamate(MSG) 4 mg/g body weight was given subcutaneously to neonatal rats

at 2, 4,6, 8 and 10th day after born to destroy the ARC, and Zuogui pill or

Yougui

pill (5 g/kg daily) was given respectively by gastrogavage when the model

rats entered adulthood. RESULTS: Immunohistochemical staining showed that in

the model group the number of corticotropin-releasing hormone (CRH) positive

neurons in hypothalamic paraventricular nucleus and anterior pituitary

adrenotrophin (ACTH) positive secretory cells, which stained deeply, were

more than those in the control group, the adrenal fasciculate zone disturbed

with increased cells and obviously dilated sinusoid. The thymus atrophied

with lymphocyte proliferation apparently lower, blood corticosterone, ACTH

content and hypothalamic CRF level higher in the model than those in the

control. Zuogui pill could improve above-mentioned pathophysiologic changes

effectively but Yougui pill could not. CONCLUSION: Process of

pathophysiology of HPA axis hyperfunction accompanied cell-mediated

immunodeficiency may belong to the category of Kidney-Yin Deficiency

Syndrome.

 

PMID: 11783216 [PubMed - indexed for MEDLINE]

 

 

[Plasma cortisol concentration and blood leukocyte content of glucocorticoid

receptors in patients with deficiency-cold vs deficiency-heat syndromes]

[Article in Chinese]

Zhang GY, Xie ZF.

Institute of the Integration of Traditional and Western Medicine, Beijing

Medical University.

 

Plasma cortisol concentration and blood leukocyte content of glucocorticoid

receptors (GCR) were assayed in 20 patients with deficiency syndromes, 10

cold in property (deficiency-cold), the other 10 hot in property

(deficiency-heat), and also in 10 healthy individuals as normal control for

the purpose of investigating the nature of cold and heat syndromes. As a

result, the cases of deficiency-cold syndrome (DCS) had a normal

concentration of plasma cortisol but a lowered content of GCR in leukocytes

when compared with the normal control (P less than 0.05); the cases of

deficiency-heat syndrome (DHS) had a higher concentration of plasma cortisol

than the normal control (P less than 0.05) and a slightly higher content of

GCR in leukocytes. It was concluded that the DCS is characterized by

diminished biological effects of adrenocortical activity, while the DHS, by

augmented biological effects of adrenocortical activity.

 

PMID: 1813169 [PubMed - indexed for MEDLINE]

 

 

: Zhong Xi Yi Jie He Za Zhi. 1989 Jan;9(1):7-9, 3. Related Articles, Links

 

[Analysis of 35 cases of pathology in yin deficiency syndrome]

[Article in Chinese]

Dai HL, Chen ZL, Song QL.

 

Thirty-five cases of the pattern of Yin deficiency were studied including 18

cases of Liver and Kidney Yin deficiency, 2 cases of Lung and Kidney Yin

deficiency, 15 cases of heat invasion into Ying and Blood with deficiency

both in Qi and Yin. These cases displayed the following characteristics: (1)

Course of the disease was insidious, protracted and prone to frequent

exacerbations. (2) Clinical manifestations resulted mostly from functional

impairment or metabolic derangements in vital organs/tissues, thus

manifesting pleomorphism and complexity. Pathologic changes could be seen in

almost all organs and tissues, being mostly marked in the liver, adrenals,

testes, gastrointestinal tract, lungs and heart. The liver showed chronic

active inflammatory changes or subacute necrosis. The adrenal cortex was

overtly atrophic, involving all zones. Cell cytoplasm was scant and red

stained with loss of lipid vesicles. The testis was also markedly atrophic.

There was interstitial edema with scattering of convoluted seminiferous

tubules. There was mild hyperplasia of the basement membrane. The germinal

cell layer was thin and spermatogenesis decreased. Gastrointestinal mucosa

was thin generally and submucosal edema was evident. Infiltrating

inflammatory cells were predominantly lymphocytes. (3) These changes could

be categorized as blood stasis, chronic inflammation, necrosis and atrophy

that signify degeneration with impairment or loss of function. As a whole,

Yin deficiency syndrome is merely a nonspecific term that covers a

conglomeration of sundry chronic disease state.

 

PMID: 2776273 [PubMed - indexed for MEDLINE]

 

1: Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Apr;19(4):215-7. Related

Articles, Links

 

 

[study on prevention and treatment of middle and aged women diabetes with

kidney deficiency and bone metabolic disturbance]

[Article in Chinese]

Zhu L, Li H, Liu Y.

Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

 

OBJECTIVE: To Study the therapeutic effect of Chinese herbal medicine (CHM)

for supplementing Qi, activating blood circulation and tonifying Kidney on

prevention and treatment of middle and aged women diabetes with Kidney

Deficiency and bone metabolic disturbance. METHODS: Clinical observation was

taken in 52 patients, who were divided into two groups, the control group

(treated with hypoglycemic agent alone) and the treated group (treated with

hypoglycemic agent and CHM). RESULTS: Before treatment, patients of both

groups showed obvious higher blood alkaline phosphatase, beta

2-microglobulin (beta 2-MG) level, urinary beta 2-MG, calcium and phosphorus

level, but lower serum estradiol level than those in normal subjects. After

3 months' treatment, no apparent change on serum estradiol level was

observed, but other parameters were all lowered obviously in the two groups,

the changes revealed more obvious in the treated group. The symptoms of

Kidney Deficiency, such as lumbodorsal pain, general fatigue, palpitation

and vertigo, were improved after treatment, and the improvement was also

more obvious in the treated group. CONCLUSION: CHM for supplementing Qi,

activating blood circulation and tonifying Kidney was effective in improving

Kidney Deficiency and mineral substance loss of bone in middle and aged

women diabetes patients. The CHM and western drugs may acted

synergistically.

 

 

1: Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Apr;13(4):202-4, 195. Related

Articles, Links

 

 

[Relation of hypothyroidism and deficiency of kidney yang]

[Article in Chinese]

Zha LL.

Inst. of the Integr. of TCM-WM Med., Shanghai Med. Univ.

 

32 cases of hypothyroidism caused by various factors were treated for one

year with Chinese medicinal herbs preparation " Shen Lu tablet " (SLT) to warm

and reinforce the Kidney Yang. 34 normal persons were studied as a control

group. After treatment with SLT, the clinical symptoms of hypothyroidism

were markedly improved. Average serum concentration of total T3, T4

increased significantly from 67.06 +/- 4.81 and 3.29 +/- 0.42 before

treatment to 120.50 +/- 6.34 ng/dl and 6.31 +/- 0.38 micrograms/dl,

respectively (P < 0.001). Serum levels of TSH decreased evidently from 20.81

+/- 2.78 before therapy to 3.32 +/- 0.61 ng/ml (P < 0.001). Before treatment

with SLT, hypothyroidism group had higher erythrocyte sodium content

([Na]Rbc) than that of normal group. The permeability of the cell membrane

oMNaos and the activity of sodium pump oKNaos in intact erythrocytes were

markedly lower in the treated group than that in the normal group. In

hypothyroidism patients treated by SLT the [Na]Rbc significantly dropped,

and the oNNaos and oKNaos were significantly raised when compared with those

before treatment, P < 0.001. It is suggested that hypothyroidism was closely

related with Deficiency of Kidney Yang and energy metabolism.

 

PMID: 8400766 [PubMed - indexed for MEDLINE]

[Guest guest]

Thanks, Jackie, for a lot of good articles. I was particularly

interested in the one on hypothyroidism. One of the first TCM

treatments that gets intergrated into Western medicine probably is

going to be considering Kidney Yang Deficiency along with the Western

treatment of supplementing thyroid hormone. There are simply too

many reports of people who are hypothyroid failing to respond

adequately to thyroid replacement. Even though blood levels come up

to the normal range and symptoms and signs improve some, treatment is

inadeaquate. Too many people with hypothyroidism still feel cold,

some still have below normal body temperatures, and other symptoms

and signs of hypothyroidism persist even after thyroid

supplementation and normal blood levels are reached. Clearly,

something else is going on too.

 

I think it's important when researchers look into TCM treatments to

have a TCM pattern diagnosis in addition to the Western diagnosis.

Even though this results in several smaller test groups instead of

one big one, it's the only way to understand what's happening and

discover exactly when something will work and when it won't. It's

that thing about treatment that helps one asthmatic may do nothing

for a second and may even make a third sicker because the underlying

TCM patterns are different. Without knowing the TCM pattern

diagnoses, researchers will get results that they don't understand

and which appear meaningless and even contradictory.

 

Victoria

[Guest guest]

> . Even though blood levels come up

> to the normal range and symptoms and signs improve some, treatment is

> inadeaquate. Too many people with hypothyroidism still feel cold,

> some still have below normal body temperatures, and other symptoms

> and signs of hypothyroidism persist even after thyroid

> supplementation and normal blood levels are reached. Clearly,

> something else is going on too.

 

Yes, and this is the kind of aspect I find most interesting. A lot of

thyroid

sufferers also have adrenal insufficiency, low cortisol, and that is the

reason for their inability to recover. Of course thyroxine does nothing for

that, but TCM might well be able to help.

 

Even though Kd yin deficiency is characterised by high cortisol levels eg

according to some of the papers I posted, Kd yin tonics also restore the

adrenal atrophy produced by steroid treatment - ie they boost the adrenals,

and maybe therefore their function (restore yin, and you restore yang to

some extent?).

 

This I think suggests that herbs like rehmannia have an adaptogenic

action on the adrenals, as well as acting on the hypothalamus/pituitary that

controls them. I think this is what my horse is falling foul of - he cannot

take

the initial adrenal 'boost'.

 

Infuriatingly I cannot find a consensus on what TCM syndromes are found with

Addison's disease? I have found one 'vote' for kidney yin deficiency so

far - anyone else have any info?

 

Addisons is of course lack of adrenal cortisol output but maybe as a result

of atrophy. It would have made my life a lot easier if it had been kd yang

deficiency, but it doesn't seem to be so??

 

Anyway I would bet that kidney yang herbs actually might restore the thyroid

gland somewhat, as well as the more yang adrenal functions maybe. Cortisol

is a

difficult hormone to classify, and there seems to be some confusion over

it - it has both yin and yang functions I think.

 

Jackie

[Guest guest]

Hi Jackie:

> But I need more - now I have come up against a

knowledge barrier in

TCM, I

> cannot find an answer to the question " Why can my kd

yin deficient

horse not

> take kd yin tonics? "

 

I really don't think you've come up against a

knowledge barrier in TCM, Jackie. You may have come up

against some sort of barrier with the TCM available in

English, but not TCM. Veterinary medicine, esp with re

to cattle and horses is very old and very essential

for people who depended on horses so much for travel.

 

As far as your actual question, I think you really

need to prepare the case properly. I often skip your

posts because it's too much information presented in a

scattered fashion. I don't have any central papr to

refer to, I never know what the weather is like over

there etc. Basically I am missing most of the info I

need. I'm sure more people will be able to help you if

you do the following:

 

1. give your papers a title with sequential numbering

so that they're easy to compile from the database.

Start with a general history.

 

2. We need to know all the -current- signs and

symptoms. Everything from his coat to his weight to

how his eyes move and how he breathes to the choices

that he makes, including his activity patterns, sleep

etc, and how any of this deviates from a healthy

horse. What he eats if it deviates from a healthy

horse. What his stool and urine are like + frequency

etc.

 

3. Tell us what the weather was like at the time of

any major symptoms or pattern changes (this is part of

history as well as ongoing, if you don't remember just

leave it out).

 

4. Do this once a week every week so we can build up a

history. Right now all I remember is a mash of

patterns. You can do it daily if you want, but I would

ask that you present us with a weekly compilation w

the high and low points, not a daily journal. It is

essential to see development and change over time.

 

As well, I really think acupuncture is necessary.

Acupuncture has a lot more to do with homeostasis than

the herbs do, so if you can find a good acupuncturist,

that would be best.

 

If you present the case to us every week in this

fashion, then over time we will be able to see the

patterns very clearly. The way we're dealing with this

case right now is extremely unfocussed, and I can see

why we can't answer your questions.

 

I also really feel that we have to go with the

horse's behaviour, not lab results or scientific

studies. That is always secondary to the individual

signs and symptoms.

 

> Infuriatingly I cannot find a consensus on what TCM

> syndromes are found with

> Addison's disease? I have found one 'vote' for

> kidney yin deficiency so

> far - anyone else have any info?

 

That is because there are no one to one

correspondences. It depends on the individual signs

and symptoms.

 

Ok, see you, hope you can do the above!

 

Hugo

 

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[Guest guest]

> I really don't think you've come up against a

> knowledge barrier in TCM, Jackie. You may have come up

> against some sort of barrier with the TCM available in

> English,

 

Sorry, that is what I meant - less than that even, a barrier within the

knowledge available to me. I'm sure some wise old Chinaman knows the answer,

but I don't have access to him.

 

> Start with a general history.

 

Okey dokey, I have his full case history and family pattern if you are

interested, and an interpretation from a LAc who works with horses a lot. I

didn't like to post it without anyone asking - it's way long!

 

Jackie

[Guest guest]

Did you try my idea of cornshuck poultice on the lower forelegs? Some horses can

do better with a different owner. Perhaps you should consider a horse trade.

Perhaps to a nice orphanage or children's home? I think a head wrap for this

horse that includes the ears being wrapped might help.

 

Hugo Ramiro <subincor wrote:Hi Jackie:

> But I need more - now I have come up against a

knowledge barrier in

TCM, I

> cannot find an answer to the question " Why can my kd

yin deficient

horse not

> take kd yin tonics? "

 

I really don't think you've come up against a

knowledge barrier in TCM, Jackie. You may have come up

against some sort of barrier with the TCM available in

English, but not TCM. Veterinary medicine, esp with re

to cattle and horses is very old and very essential

for people who depended on horses so much for travel.

 

As far as your actual question, I think you really

need to prepare the case properly. I often skip your

posts because it's too much information presented in a

scattered fashion. I don't have any central papr to

refer to, I never know what the weather is like over

there etc. Basically I am missing most of the info I

need. I'm sure more people will be able to help you if

you do the following:

 

1. give your papers a title with sequential numbering

so that they're easy to compile from the database.

Start with a general history.

 

2. We need to know all the -current- signs and

symptoms. Everything from his coat to his weight to

how his eyes move and how he breathes to the choices

that he makes, including his activity patterns, sleep

etc, and how any of this deviates from a healthy

horse. What he eats if it deviates from a healthy

horse. What his stool and urine are like + frequency

etc.

 

3. Tell us what the weather was like at the time of

any major symptoms or pattern changes (this is part of

history as well as ongoing, if you don't remember just

leave it out).

 

4. Do this once a week every week so we can build up a

history. Right now all I remember is a mash of

patterns. You can do it daily if you want, but I would

ask that you present us with a weekly compilation w

the high and low points, not a daily journal. It is

essential to see development and change over time.

 

As well, I really think acupuncture is necessary.

Acupuncture has a lot more to do with homeostasis than

the herbs do, so if you can find a good acupuncturist,

that would be best.

 

If you present the case to us every week in this

fashion, then over time we will be able to see the

patterns very clearly. The way we're dealing with this

case right now is extremely unfocussed, and I can see

why we can't answer your questions.

 

I also really feel that we have to go with the

horse's behaviour, not lab results or scientific

studies. That is always secondary to the individual

signs and symptoms.

 

> Infuriatingly I cannot find a consensus on what TCM

> syndromes are found with

> Addison's disease? I have found one 'vote' for

> kidney yin deficiency so

> far - anyone else have any info?

 

That is because there are no one to one

correspondences. It depends on the individual signs

and symptoms.

 

Ok, see you, hope you can do the above!

 

Hugo

 

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Want to chat instantly with your online friends? Get the FREE

Messenger http://uk.messenger./

 

 

[Guest guest]

> Did you try my idea of cornshuck poultice on the lower forelegs?

 

Ice bandage did the trick thanks.

 

Some horses can do better with a different owner. Perhaps you should

consider a horse trade. Perhaps to a nice orphanage or children's home?

 

Oh dear - 640kg of aggressive, dominant horse at an orphanage? No, he needs

a massive amount of support and would suffer a great deal more with someone

who didn't understand his condition at all. He's also untradable, would very

sson end up in a can.

 

Jackie