PSA levels after withdrawal of androgen block

[Guest guest]

Hi Sammy,

 

> Results: After withdrawal of androgen block and return to normal

> male androgen levels, an increase in PSA trend (straight line log

> plot) was observed for several months. Thereafter PSA failed to

> reach predicted values in the Gompertzian model of tumour growth

> and instead stabilised as androgen levels were maintained at normal

> values with reference to the average male.

 

Sammy, please confirm that the last sentence is correct, or should

it read:

 

> Thereafter PSA failed to reach predicted values in the Gompertzian

> model of tumour growth and instead stabilised at normal values as

> androgen levels were maintained with reference to the average

> male.

 

What I am trying to ascertain is: did PSA levels stay up or return to

normal levels after withdrawal of androgen block?

 

 

Best regards,

 

Email: <

 

WORK : Teagasc Research Management, Sandymount Ave., Dublin 4, Ireland

Mobile: 353-; [in the Republic: 0]

 

HOME : 1 Esker Lawns, Lucan, Dublin, Ireland

Tel : 353-; [in the Republic: 0]

WWW : http://homepage.eircom.net/~progers/searchap.htm

[Guest guest]

There is some overlap because what is 'normal' for one man may be out of

range for another. You have to consider the whole spectrum of possibilities

and the fact that " predicted values in the Gompertzian model of tumour

growth " are not attained by an order of magnitude (i.e. x1000 less than

expected). The best way to answer this question is to get your patients to

do a regular PSA test and at the same time counsel them that a 'high'

reading is only significant 1. If it is accompanied by persistent symptoms

and 2. If it continues to rise despite treatment. If you can stabilise a

patient's PSA at say 10 or even 20 and they have no symptoms and are free

from metastatic disease evidenced by a scintigraphy bone scan then you are

managing that disease in a manner that is infinitely more preferable to

castrating the guy and having him suffer all the awful side effects of that

disorder as well. Sammy.

 

 

[]

21 January 2004 22:20

Chinese Medicine

Re: PSA levels after withdrawal of androgen block

 

Hi Sammy,

 

> Results: After withdrawal of androgen block and return to normal

> male androgen levels, an increase in PSA trend (straight line log

> plot) was observed for several months. Thereafter PSA failed to

> reach predicted values in the Gompertzian model of tumour growth

> and instead stabilised as androgen levels were maintained at normal

> values with reference to the average male.

 

Sammy, please confirm that the last sentence is correct, or should

it read:

 

> Thereafter PSA failed to reach predicted values in the Gompertzian

> model of tumour growth and instead stabilised at normal values as

> androgen levels were maintained with reference to the average

> male.

 

What I am trying to ascertain is: did PSA levels stay up or return to

normal levels after withdrawal of androgen block?

 

 

Best regards,

 

Email: <

 

WORK : Teagasc Research Management, Sandymount Ave., Dublin 4, Ireland

Mobile: 353-; [in the Republic: 0]

 

HOME : 1 Esker Lawns, Lucan, Dublin, Ireland

Tel : 353-; [in the Republic: 0]

WWW : http://homepage.eircom.net/~progers/searchap.htm

 

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