Guest guest Posted June 25, 2005 Report Share Posted June 25, 2005 Use of Prescription Drugs During Pregnancy * * * * * * * * * * * * * * * * * * * * * * * * * * * MYCOPLASMA REGISTRY REPORTS for gulf war syndrome & chronic fatigue syndrome © Sean Dudley & Leslee Dudley June 24, 2005. All rights reserved. MycoplasmaRegistry/ MycoReg * * * * * * * * * * * * * * * * * * * * * * * * * * * Dangers of Doxycycline, Minocycline and Tetracycline for Women, Unborn and Newborn Children by Leslee Dudley and Sean Dudley ©2005. All rights reserved. Doxycycline is used with minimal side effects for Mycoplasma fermentans, Lyme Disease, Autoimmune Diseases and other conditions. However, doxycycline, as well as minocycline and tetracycline which are in the same family, are counter indicated for pregnant women because they are dangerous for fetuses and infants. This fact is taught in medical schools and is included in all prescription drug books. Warnings are also printed on all package inserts and in warnings dispensed by individual pharmacies. In spite of this, the study " Prescription drug use in pregnancy * " found that physicians still prescribe not only doxycycline but other dangerous drugs to pregnant women. The study found that doxycycline was one of the " Class D Category Drugs " that were negligently prescribed to pregnant women, stating: " ...almost one half of the women in this study received medications that have no evidence of safety during pregnancy or for which evidence shows a risk to the fetus in animals or humans. ... " This study demonstrates that women can not solely depend on their physicians to protect them during their child bearing years. Most drugs are tested on men because of the danger that women may become pregnant during the drug trials. The warnings about damage to fetuses comes from either animal experiments or real life experiences of women, such as was the case with thalidomide. The warnings concerning the tetracycline class of antibiotics comes from actual recorded side effects to unborn and newborn children and should be taken seriously. However, the warning concerning the tetracycline class of antibiotics, as well as ampicillin, causing bill control pills to fail, is based on outdated and unreliable data. More recent studies based on statistical data have shown that antibiotics do not increase the pregnancy rate. Women need to research all the drugs they are prescribed and should discuss the dangers and side effects with their physicians. We have created a recommendation list specifically for women with mycoplasma infections, Lyme Disease and autoimmune diseases concerning the tetracycline class of antibiotics. RECOMMENDATIONS FOR WOMEN, UNBORN & NEWBORN CHILDREN TAKING DOXYCYCLINE, MINOCYCLINE AND TETRACYCLINE BIRTH CONTROL • Historically, data from over twenty years ago seemed to indicate that tetracycline might interfere with the effectiveness of birth control pills. It was recommended that women use a second method of birth control to ensure protection from unintended pregnancy while taking the tetracycline class of antibiotics: doxycycline, minocycline and tetracycline. • However, all of the recent studies have shown that antibiotics do not increase the pregnancy rate. PREGNANCY • Doxycycline, minocycline and tetracycline can harm the fetus. • Do not take doxycycline, minocycline or tetracycline without first talking to your doctor if you are pregnant or could become pregnant during treatment. • If you become pregnant while taking doxycycline minocycline or tetracycline, call your doctor immediately. • Doxycycline, minocycline and tetracycline are in the FDA pregnancy " ...Category D: There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective)... " • Doxycycline, minocycline and tetracycline taken during the second or third trimester of pregnancy can stain newborns teeth. They can cause up to a 40% depression of bone growth, especially of the fibula in pre-term pregnancies. However, after birth, rapid compensatory bone growth has been observed once antibiotic treatment is terminated. BREAST-FEEDING • Do not take doxycycline, minocycline or tetracycline if you are breast-feeding a baby, without first talking to your doctor. • Doxycycline, minocycline and tetracycline pass into breast milk and may decrease bone and tooth development, as well as cause dental staining in a nursing infant. • Doxycycline, minocycline and tetracycline might possibly cause increased neonatal toxicity. • Doxycycline, minocycline and tetracycline may disturb the balance of bowel flora of a nursing infant and cause candidiasis. ### by Sean Dudley & Leslee Dudley, Mycoplasma Registry © All Rights Reserved * Prescription drug use in pregnancy. Andrade SE, Gurwitz JH, Davis RL, Chan KA, Finkelstein JA, Fortman K, McPhillips H,Raebel MA,Roblin D,Smith DH,Yood MU,Morse AN,Platt R. Meyers Primary Care Institute-Fallon Healthcare System and University of Massachusetts Medical School, 630 Plantation Street, Worcester, MA, USA. sandrade Am J Obstet Gynecol. 2004 Aug;191(2):398-407. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search & DB=pubmed * * * * * * * * * * * * * * * * * * * * * * * * * * * Use of Prescription Drugs During Pregnancy RedNova.com, TX - June 16, 2005 http://www.rednova.com/news/health/156412/use_of_prescription_drugs_du ring_pregnancy/ Although strongly discouraged by many authorities, a significant number of women continue to use prescription medications during pregnancy, placing themselves and their fetuses at risk for adverse outcomes. Studies in Europe have shown that a significant number of pregnant women receive prescription medications that are labeled as potentially harmful to the fetus and a small percentage receive prescriptions for medications that are absolutely contraindicated during pregnancy. Andrade and colleagues performed a retrospective evaluation to determine the use of prescription drugs in pregnant women in the United States. Researchers studied automated databases from eight health maintenance organizations. Women who delivered an infant in a hospital from January 1, 1996, through December 31, 2000, were identified. To be included in the study, the women had to have participated in a prescription drug plan for at least one year before their delivery date. The gestational period was assumed to begin 270 days before the delivery date with an additional 90-day period before pregnancy included in the analysis. The date that the pregnancy was established in the database was given as the earliest prenatal care visit within 270 days of delivery. Data were excluded if there was no evidence of prenatal care in this period. Information obtained from the database included prescription drugs dispensed and inpatient and outpatient diagnoses and procedures. All medications prescribed during the study were labeled according to the U.S. Food and Drug Administration (FDA) risk classification (A, B, C, D, and X). Class and Frequency of Drugs Prescribed During Pregnancy A total of 152,531 deliveries were identified and included in the study. For 64 percent of these deliveries, a drug other than vitamin or mineral supplements was prescribed within the 270 days before delivery; a breakdown by FDA class is given in the accompanying table. After the first prenatal visit, 59 percent of the participants received a drug other than vitamin or mineral supplements, with 3.4 percent receiving a category D medication and 1.1 percent receiving a category X medication. The most common category D medications used, excluding female hormones and ovulation stimulants, included atenolol, secobarbital, doxycycline, lorazepam and clonazepam. The most common category X medications prescribed, other than female hormones and ovulation stimulants, included: temazepam, flurazepam, testosterone, misoprostol, and triazolam. Misoprostol was dispensed in the third trimester and used for cervical ripening exclusively in 12 of 13 women prescribed the drug. The authors conclude that almost one half of the women in this study received medications that have no evidence of safety during pregnancy or for which evidence shows a risk to the fetus in animals or humans. They add that these results indicate the need to develop and implement systems that eliminate the exposure of pregnant women to these medications. Andrade SE, et al. Prescription drug use in pregnancy. Am J Obstet Gynecol August 2004;191:398-407. KARL E. MILLER, M.D. Copyright American Academy of Family Physicians Jun 1, 2005 Story from REDNOVA NEWS: http://www.rednova.com/news/display/? id=156412 © Rednova 2004 * * * * * * * * * * * * * * * * * * * * * * * * * * * FREE BROCHURE: " How to Get an Accurate Polymerase Chain Reaction (PRC) Blood Test for Mycoplasmal and Other Infections-with a List of International Laboratories " © by Sean and Leslee Dudley is sent automatically and immediately to all new rs. It is updated with current information and the new version is posted to the Mycoplasma Registry Reports & News list each month. MycoplasmaRegistry- FAIR USE: In accordance with Title 17 U.S.C. Section 107, this material is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes. The Mycoplasma Registry has no affiliation with the originator of this article nor is the Mycoplasma Registry endorsed or sponsored by the originator. 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