Guest guest Posted August 29, 2005 Report Share Posted August 29, 2005 Selenium Ameliorates Damaging Effects of Mercury JoAnn Guest Aug 29, 2005 07:29 PDT ==================================================================== http://www.willner.com/article.aspx?artid=182 Selenium is present in all the tissues of the body, but is concentrated most highly in the kidneys, liver, spleen, pancreas, and testes. People do not consume enough selenium both because of the type of diet they eat, and because of the low selenium content of the soil in which their food is grown. The selenium content of soil varies widely, with many areas showing serious depletion. In fact, there have been several reports of selenium deficiencies in livestock raised on selenium-depleted soil. FUNCTIONS AND USES Cancer Selenium’s best-known and perhaps most important biological function relates to its role as an antioxidant and anticancer mineral. As we have seen in other chapters, free radicals damage our cells, possibly leading to the development of cancer and other degenerative diseases. Selenium is an activating component of the enzyme glutathione peroxidase, which protects our cells from this damage. Many animal studies have proven that selenium deficiency increases the incidence and rate of growth of cancers in animals that are either exposed to a variety of potent carcinogens or receive transplanted tumors. Companion studies have shown that high selenium intake protects against these cancers. For example, in one study in which rats were exposed to a potent carcinogen, only 15 percent of those who were also given selenium developed liver cancer as compared with 90 percent of the unsupplemented rats. In another study, the occurrence of cancer was 10 percent in the supplemented group versus 80 percent in the control group. In yet another animal study, selenium supplementation reduced colon cancer incidence by more than 50 percent. In another study, selenium protected against UV-induced skin damage and cancer, retarding the onset and number of skin lesions, and reducing inflammation, bistering, and pigmentation. In. humans, there is ample epidemiological evidence that high selenium is correlated with a lower incidence of many types of cancer. For instance researchers have found that cancer risk is significantly lower in people living in areas with selenium-rich soil, in people with a high-selenium food supply, and in people with higher blood levels of selenium, when compared with people with lower intakes and blood levels. Selenium intakes in the people studied were close to 750 micrograms per day, with no toxic side effects noted. In a survey that spanned twenty-seven countries, including the United States, it was found that the cancer death rate was lower in those people whose typical diets were high in selenium. This and other cancer studies indicate that selenium is especially protective against cancer of the breast, colon, and lung. Data also suggests protection against tumors of the ovaries, cervix, rectum, bladder, esophagus, pancreas, skin, liver, and prostate, as well as against leukemia. Since 1969, it has been known that the blood levels of cancer patients are low in selenium. In general, cancer patients with lower-than-average selenium levels have a greater number of primary tumors, more recurrences, more distant metastases (tumors that have spread to distant parts of the body), and a shortened survival time. In a study of 12,000 people conducted in Finland, the risk of fatal cancer in people with the lwest levels of serum selenium was nearly six times higher than that in people with the highest selenium concentrations. Like other nutrients, of course, selenium cannot do its work alone. In several studies, it has been shown that selenium and vitamin E-and perhaps vitamin A, too—have a synergistic effect. For example, in one study, male smokers who died of cancer had lower levels of serum selenium, vitamin A, and vitamin E, when compared with healthy control subjects. It is well known that vitamin E enhances the antioxidant effect of selenium. In. addition, it has been found that supplementation with selenium alone and with selenium plus vitamin E in excess of the RDAs stimulates the immune system in experimental animals. This effect is particularly pronounced when the diet is high in polyunsaturated fats- a factor that has been linked to a higher incidence of certain cancers. These studies show promise for the prevention and possible treatment of cancer with selenium supplementation. When combined with other supplements, the anticancer effect may be even greater. The National Cancer Inistitute is conducting ongoing " chemopreventive " trials of several individual nutrients, including selenium, vitamin E, and vitamin A. However, often these trials are limited to 200 micrograms of selenium per day, which may be too low a dose to assess the potential protective effect of this mineral. Larger doses of selenium have been shown to be protective in animals, and safe in humans. In addition, we are not sure of the extent to which selenium supplementation influences the later stages of cancer development. If its influence is strongest in the early stage, it will be very difficult for these trials to prove the connection between low selenium and cancer because of the long latency period for most cancers. (For example, it may take up to fourteen years for a single breast cancer cell to multiply and produce a tumor large enough to be detected by currently available diagnostic methods.) Finally, evidence of the synergism of nutrients has led many researchers to emphasize the need to consider several nutrients in any given diet and cancer study, instead of focusing on just one nutrient per study. Cardiovascular Disease In humans, a link has been found between selenium and heart disease. People found to have overt selenium deficiencies-alcoholics with cirrhosis of the liver, and people receiving long-term intravenous feeding-have also been found to suffer from heart problems that respond to selenium supplementation. In eastern Finland, which has one of the highest mortality rates from heart disease in the world, it was found that low selenium in the blood was associated with up to a six- or sevenfold increase in the risk of death from heart disease. In addition, children in certain areas of China in which the selenium content of the soil is low are known to develop a heart disease called Keshan’s disease. Their heart problems, too, respond to selenium supplementation. Other Functions There is some evidence that selenium may also prove effective in the treatment or prevention of several other disorders. A study using 400 micrograms of selenium and approximately 25 international units of vitamin E markedly improved skin conditions such as acne and seborrheic dermatitis in the test subjects. A Danish study examined patients with rheumatoid arthritis and found that they had lower levels of selenium. Those with the lowest levels had the more severe form of this disease. Moreover, a recent study conducted in Japan suggests that selenium and vitamin E may enhance the responsiveness of arthritis patients to conventional treatment. A fascinating study conducted in Scandinavia showed a correlation between low selenium levels and the incidence and severity of muscular dystrophy; one patient who was treated with selenium supplements showed considerable improvement after one year. Finnish researchers have also conducted a study on elderly patients, who were given large doses of selenium and vitamin E for one year. After two months, researchers found an obvious improvement in their patients’ mental well-being, including less fatigue, depression, and anxiety, and more mental alertness, motivation, and self-care. Finally, selenium has been shown to protect against the " TOXIC EFFECTS " of MERCURY, ARSENIC, and COPPER!!!! ====================================================================== RDIs AND DEFICIENCY SYMPTOMS Selenium deficiency symptoms may include muscular weakness and discomfort. Recent studies have shown that people with celiac disease-an inborn inability to digest glutenare at high risk for low selenium, along with other nutrients, either because their lowgluten diets are also low in selenium, or because of their absorption problems. Down’s syndrome patients have also been found to have low levels of selenium and other antioxidants. In one study, refinery workers were found to have low selenium levels in spite of their dietary intake of 217 micrograms per day, which is more than three times higher than the RDI. This study indicates that because of the workers’ exposure to free radicals on the job, their bodies were utilizing large amounts of selenium to produce the protective enzyme glutathione peroxidase. This suggests that exposure to toxic environmental chemicals increases the requirement for this mineral. The RDI for selenium is 70 micrograms for all men and women. Food Sources: There are no accurate available measurements of the selenium content of foods. However, it appears that the richest sources of selenium are seafoods, meats, and organ meats-if the animals of origin ate a diet high in selenium. Whole grains can be good sources, but, similarly, this depends on the selenium content of the soil in which they were grown. Fruits and vegetables generally contain very low amounts of selenium. The refining process strips foods of much of their selenium content. In one study, it was found that a highly refined diet contains 61 percent less selenium than does a diet rich in unrefined foods. Cooking also reduces the content significantly, especially if the cooking water is discarded. Vitamin C seems to enhance the absorption of selenium. SUPPLEMENTS Selenium is most often available as an individual supplement, although some multivitamin-mineral formulas are beginning to include this mineral. I recommend selenium in the form of selenomethionine, which is extracted from selenium-rich yeast or ocean plants. This form is the least toxic and appears to be the most " absorbable " . OPTIMUM DAILY INTAKE-ODI For optimum general health, the basic Optimum Daily Intake for selenium is: 100-400 mcg for men and women living in low-selenium areas (this includes coastal areas and glaciated areas) 50-200 mcg for men and women living in high-selenium areas The above is excerpted from the book The Real Vitamin & Mineral Book, by Shari Lieberman, Ph.D and Nancy Bruning, Avery Publishing, 1997 ==================================================================== WE NOW KNOW THAT CONSUMPTION OF COLD WATER FISH: ===================================================================== *Thins the blood *Protects arteries from damage. *Inhibits blood clots (anti-thrombotic) *Reduces blood triglycerides *Lowers LDL blood cholesterol *Lowers blood pressure *Reduces risk of heart attack and stroke *Eases symptoms of rheumatoid arthritis *Reduces risk of lupus *Relieves migraine headaches *Fights inflammation *Helps regulate the immune system *Inhibits cancer in animals (and possibly humans) *Soothes bronchial asthma *Combats early kidney disease The key to the " healing powers " of fish lies in the omega-3 fatty acids. These are particularly concentrated in cold-water fish such as anchovies, bluefish, herring lake trout, mackerel, sablefish, whitefish, alaskan salmon and sardines in water. For more than 200 years, cod-liver oil was prescribed for a number of ailments, including rheumatism and arthritis, because, it was believed, it could " lubricate the joints. " But it was not until 1985 that doctors writing in the New England Journal of medicine recommended that arthritis sufferers could benefit from eating fish once or twice a week. In the case of arthritis, for example, the omega-3 oils do " lubricate " the joints by reducing painful inflammation. The National Institute of Arthritis and Musculoskeletal and Skin Diseases says the oils*…unquestionably are anti-inflammatory agents. " Research funded through the Institute demonstrated that these oils blocked the *formation* of something called leukotriene B4, which triggers inflammation. The Institute reported *…a significant correlation between the drop in leukotriene B4 and decrease in the number of tender joints… " after the oils were prescribed. Other research at Albany Medical College, New York, confirmed these findings. Dr. Joel M. Kramer, an associate professor of medicine, observed that patients who received omega-3 in capsule form daily for 14 weeks suffered less pain than before the oil treatment. Their stamina was also much improved. The three capsules were equivalent to the amount of oil contained in the average salmon dinner or one can of sardines, yet the pain was significantly relieved for several days after the omega-3 treatment period ended. " Systemic lupus erythematosis " , another inflammatory disease that attacks the skin, also reacted positively to experimental fish oil treatments, leading on Harvard researcher to proclaim it as " …the most striking protective effect ever seen. " Fish oil was once something of a joke among many nutritionists. No one is laughing today about the healing powers of fish. Certain seafoods appear to even offer protection against killers like heart disease and cancer. The reason it would seem, is that the natural oils found in fish appear to curtail the body's overproduction of several hormone-like substances called prostaglandins and leukotrienes. Overactive prostaglandins and leukotrienes can " cause " blood clots, inflammations, and serious " glitches " in the immune system. Omega-3 oils halt these destructive reactions before they get out of control, something that is critical in preventing heart disease – today's number one killer. There are three villains lurking deep inside our bodies that cause heart attacks and strokes. They are the plaque that can clog arteries and dangerously restrict blood flow; the accumulation platelets (sticky pieces of blood cells) that clump together and form clots, and the sudden unexplained spasms of blood vessels that can throw the heart out of kilter or halt the flow of blood to the brain, causing strokes. Studies on fish oil show it works wonders in reducing or eliminating all three risks. People who eat lots of fish seem to have thinner blood, which is less " prone " to clotting. Omega –3 oils also reduce triglycerides and dangerous LDL cholesterol and that, say the experts, may be why fish is such a powerful ally in the battle against heart disease. Eskimos eat about 13 ounces of omega-3 rich seafood a day and rarely ever suffer from heart attacks. The same is true of Japanese fishermen and their families who consume, on average, at least seven ounces of fish daily. Norwegian scientists recently discovered that a mere three ounces of mackerel in the daily diet, thins the blood within six weeks, significantly reducing the risks of clogged arteries, heart attacks and strokes. In Britain, a study involving hundreds of participants revealed that those on a heavy fish diet developed higher concentrations of " good " HDL cholesterol than even vegetarians. The best news is that it might not even take very much fish to fight off heart disease. Researchers at the University of Leiden in the Netherlands monitored residents of one small town who ate only one ounce of fish a week. The results were astonishing. The risk of heart disease in the study group was 50 percent, less than among those who ate no fish at all. Experts warn that hypertension, or high blood pressure, is the red light warning us that a life-threatening heart attack may be headed toward us like a runaway train. To stop it, they say, get that blood pressure under control! The Central Institute for Cardiovascular Research in Berlin studied 24 men with slightly elevated blood pressure. For two weeks, half of the group dined daily on two seven-ounce cans of mackerel and followed that with three cans a week for the next eight months. Mackerel was chosen for its very high levels of omega-3 oils. The results? The higher the levels of omega-3 fatty acids in their blood, the more their blood pressure dropped. The conclusion: A minimum of only three ounces of mackerel a week lowered blood pressure about seven percent- and eliminated the need for medication. Fish oils seem to be just as important in fighting cancer. Those over active prostaglandins that may touch off heart problems, are also present in most cancers, says Rutgers University researcher Dr. Rashida Karmali, Now, encouraging studies at Rutgers and elsewhere indicate that fish oils are highly effective at putting the clamps on that overproduction. And once the heavy concentration of those nasty prostaglandins is reduced, the risks of breast, pancreatic, lung, prostate and colon cancer also drops. Eskimo and Japanese women for example eat lost of fish and seldom develop breast cancer. Migraine sufferers too may find relief with omega-3 fish oils, according to a team of researchers at the University of Cincinnati, Of those who took part in that study, 60 percent reported that their chronic migraines were less severe and the frequency reduced by half over six weeks when they took fish oil capsules. The average number of attacks dropped from two a week to two every two weeks.For some reason, men seemed to benefit more from the fish oils than women?? A change in diet in which omega-3 fish oils replaced animal fats also dramatically slowed down the rate of deterioration in people suffering early kidney disease. Fish oil may also help women who suffer from painful menstrual cramps. These are apparently triggered by the same overactive prostaglandins that are the cause of so many other problems. Asthma appears to be another of those inflammatory diseases in which leukotrienes get out of hand and cause bronchial constriction. Fish oils added to the diet have given outstanding relief in many cases, again by stifling the over active leukotrienes production. The condition of about two-thirds of psoriasis patients in another study improved after they started taking omeg-3 fish oils, the Oils seemed to move quickly into the blood and to the surface of the skin. The more oils that reached the epidermis, the more startling the improvement. Remember the old wives tale about fish being a " brain food " that makes you smarter? Not true, say the experts, BUT the ingredients in fish and fish oils do make it possible for you to boost your potential, especially when you are fatigued and your mental energies are low. The secret this time is not as much in the omega-3 oils, but in a natural chemical in the fish called tyrosine. Dr. Judith Wurtman, head of research team at the Massachusetts Institute of Technology, discovered that seafood is high in this potent amino acid. It apparently " stimulates " the brain into " producing " extra norepinephrine and dopamine. These are the " neurotransmitters " that the brain needs to keep functioning at peak efficiency. And that makes us feel more alert. Concerns about high mercury content of certain seafoods can be " alleviated " by taking 200 mcgs or more of Selenium on a daily basis. One of the benefits of Selenium is that it tends to flush heavy metals out more swiftly,eliminating the possibility of serious liver damage. --- Post subject: Fish Oils: The Essential Nutrients --- by Hans R. Larsen, MSc ChE There are good fats and there are bad fats. Artificially produced trans-fatty acids are bad in any amount and saturated fats from animal products should be kept to a minimum. The best fats or oils rather, since they are liquid at room temperature, are those that contain the essential fatty acids so named because without them we die. Essential fatty acids are polyunsaturated and grouped into two families, the omega-6 EFAs and the omega-3 EFAs. Seemingly minor differences in their molecular structure make the two EFA families act very differently in the body. While the metabolic products of omega-6 acids promote inflammation, blood clotting, and tumor growth, the omega-3 acids act entirely opposite. Although we do need both omega-3s and omega-6s it is becoming increasingly clear that an excess of omega-6 fatty acids can have dire consequences. Many scientists believe that a major reason for the high incidence of heart disease, hypertension, diabetes, obesity, premature aging, and some forms of cancer is the profound imbalance between our intake of omega-6 and omega-3 fatty acids. Our ancestors evolved on a diet with a ratio of omega-6 to omega-3 of about 1:1. A massive change in dietary habits over the last few centuries has changed this ratio to something closer to 20:1 and this spells trouble. [1-3] Sources and requirements The main sources of omega-6 fatty acids are vegetable oils such as corn oil and soybean oil that contain a high proportion of linoleic acid. Omega-3 acids are found in flaxseed oil, walnut oil, and marine plankton and fatty fish. The main component of flaxseed and walnut oils is alpha-linolenic acid while the predominant fatty acids found in fatty fish and fish oils are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The most beneficial and active of these fatty acids are EPA and DHA. Alpha-linolenic acid can be converted to EPA and DHA in the body, but the conversion is quite inefficient especially in older people. [1, 2] Scientists were first alerted to the many benefits of EPA and DHA in the early 1970s when Danish physicians observed that Greenland Eskimos had an exceptionally low incidence of heart disease and arthritis despite the fact that they consumed a high-fat diet. Intensive research soon discovered that two of the fats (oils) they consumed in large quantities, EPA and DHA, were actually highly beneficial. More recent research has established that fish oils (EPA and DHA) play a crucial role in the prevention of atherosclerosis, heart attack, depression, and cancer. Clinical trials have shown that fish oil supplementation is effective in the treatment of many disorders including rheumatoid arthritis, diabetes, ulcerative colitis, and Raynaud's disease. [1-5] Recognizing the unique benefits of EPA and DHA and the serious consequences of a deficiency the US National Institutes of Health recently published Recommended Daily Intakes of fatty acids. They recommend a total daily intake of 650 mg of EPA and DHA, 2.22 g/day of alpha-linolenic acid and 4.44 g/day of linoleic acid. Saturated fat intake should not exceed 8 per cent of total calorie intake or about 18 g/day. Good for the brain and children too The human brain is one of the largest " consumers " of DHA. A normal adult human brain contains more than 20 grams of DHA. Low DHA levels have been linked to low brain serotonin levels which again are connected to an increased tendency to depression, suicide, and violence. A high intake of fish has been linked to a significant decrease in age-related memory loss and cognitive function impairment and a lower risk of developing Alzheimer's disease. A recent study found that Alzheimer's patients given an omega-3-rich supplement experienced a significant improvement in their quality of life.[6-9] Several studies have established a clear association between low levels of omega-3 fatty acids and depression. Other studies have shown that countries with a high level of fish consumption have fewer cases of depression. Researchers at Harvard Medical School have successfully used fish oil supplementation to treat bipolar disorder (manic-depressive illness) and British researchers report encouraging results in the treatment of schizophrenia. [10-15] An adequate intake of DHA and EPA is particularly important during pregnancy and lactation. During this time the mother must supply all the baby's needs for DHA and EPA because it is unable to synthesize these essential fatty acids itself. DHA makes up 15 to 20% of the cerebral cortex and 30 to 60% of the retina so it is absolutely necessary for normal development of the fetus and baby. There is some evidence that an insufficient intake of omega-3 fatty acids may increase the risk of premature birth and an abnormally low birth weight. There is also emerging evidence that low levels of omega-3 acids are associated with hyperactivity in children. [1, 3, 16- 22] The constant drain on a mother's DHA reserves can easily lead to a deficiency and some researchers believe that preeclampsia (pregnancy-related high blood pressure) and postpartum depression could be linked to a DHA deficiency. Experts recommend that women get at least 500-600 mg of DHA every day during pregnancy and lactation. The easiest way to ensure this intake is to take a good fish oil supplement daily. [17-19] Researchers at the University of Sydney have found that children who regularly eat fresh, oily fish have a four times lower risk of developing asthma than do children who rarely eat such fish. They speculate that EPA present in the fish may prevent the development of asthma or reduce its severity by reducing airway inflammation and responsiveness. Researchers at the University of Wyoming have found that supplementation with 3.3 grams/day of fish oil markedly reduces breathing difficulties and other symptoms in asthma patients. Other research has found fish oil to be beneficial in the treatment of other lung diseases such as cystic fibrosis and emphysema. [23- 29] The heart's best friend An enormous amount of medical literature testifies to the fact that fish oils prevent and may help to ameliorate or reverse atherosclerosis, angina, heart attack, congestive heart failure, arrhythmias, stroke, and peripheral vascular disease. Fish oils help maintain the elasticity of artery walls, prevent blood clotting, reduce blood pressure and stabilize heart rhythm. [1-4, 30-33] Danish researchers have concluded that fish oil supplementation may help prevent arrhythmias and sudden cardiac death in healthy men. An Italian study of 11,000 heart attack survivors found that patients supplementing with fish oils markedly reduced their risk of another heart attack, a stroke or death. A group of German researchers found that fish oil supplementation for 2 years caused regression of atherosclerotic deposits and American medical researchers report that men who consume fish once or more every week have a 50% lower risk of dying from a sudden cardiac event than do men who eat fish less than once a month. [34-40] Greek researchers report that fish oil supplementation (10 grams/day) reduces the number of attacks by 41% in men suffering from angina. Norwegian medical doctors have found that fish oil supplementation reduces the severity of a heart attack and Indian researchers report that supplementation started immediately after a heart attack reduces future complications. Bypass surgery and angioplasty patients reportedly also benefit from fish oils and clinical trials have shown that fish oils are safe for heart disease patients. The evidence is indeed overwhelming. An adequate daily intake (about 1 gram) of EPA and DHA is essential to maintain a healthy heart. Fish oils are especially important for diabetics who have an increased risk of heart disease. [41- 49] Researchers at the University of Cincinnati have found that supplementing with as little as 2 grams/day of fish oil (410 mg of EPA plus 285 mg of DHA) can lower diastolic pressure by 4.4 mm Hg and systolic pressure by 6.5 mm Hg in people with elevated blood pressure. Enough to avoid taking drugs in cases of borderline hypertension. Several other clinical trials have confirmed that fish oils are indeed effective in lowering high blood pressure and that they may work even better if combined with a program of salt restriction. [50-55] Reduces pain and helps prevent cancer Fish oils are particularly effective in reducing inflammation and can be of great benefit to people suffering from rheumatoid arthritis or ulcerative colitis. Daily supplementation with as little as 2.7 grams of EPA and 1.8 grams of DHA can markedly reduce the number of tender joints and increase the time before fatigue sets in. Some studies have also noted a decrease in morning stiffness and at least two clinical trials concluded that arthritis patients who took fish oils could eliminate or sharply reduce their use of NSAIDs and other arthritis drugs. [56-61] Patients with ulcerative colitis have abnormally low blood levels of EPA. Clinical trials have shown that supplementation with fish oil (2.7 grams of EPA and 1.8 grams of DHA daily) can reduce the severity of the condition by more than 50% and enable many patients to discontinue anti-inflammatory medication and steroids. [62-64] There is now also considerable evidence that fish oil consumption can delay or reduce tumor development in breast cancer. Studies have also shown that a high blood level of omega-3 fatty acids combined with a low level of omega-6 acids reduces the risk of developing breast cancer. Daily supplementation with as little as 2.5 grams of fish oils has been found effective in preventing the progression from benign polyps to colon cancer and Korean researchers recently reported that prostate cancer patients have low blood levels of omega-3 fatty acids. Greek researchers report that fish oil supplementation improves survival and quality of life in terminally ill cancer patients. [65-73] Safe and easily available It is estimated that 85% or more of people in the Western world are deficient in omega-3 fatty acids and most get far too much of the omega-6 fatty acids. The recommended daily intake of EPA plus DHA is about 650 mg rising to 1000 mg/day during pregnancy and lactation. Clinical trials have used anywhere from 1 g/day to 10 g/day, but little additional benefit has been observed at levels above 5 g/day of EPA and DHA combined. The benefits of therapeutic supplementation may become evident in a few weeks when blood parameters (triglycerides, fibrinogen) are involved, but may take 3 months or longer to materialize in degenerative diseases like atherosclerosis and rheumatoid arthritis. [74, 75] The processing and packaging of the fish oil are crucial in determining its quality. Low quality oils may be quite unstable and contain significant amounts of mercury, pesticides, and undesirable oxidation products. High quality oils are stabilized with adequate amounts of vitamin E and are packaged in individual foil pouches or other packaging impervious to light and oxygen. Some very recent research carried out at the University of Minnesota found that emulsified fish oils are much better absorbed than the straight oils in gelatin capsules. [76] Cod liver oils and fish oils are not the same. Cod liver oil is extracted from cod liver and is an excellent source of vitamins A and D. Fish oils are extracted from the tissues (flesh) of fatty fish like salmon and herring and are good sources of EPA and DHA. Fish oils contain very little vitamin A and D, but cod liver oil does contain EPA and DHA. However, you would probably exceed the recommended daily intake of vitamins A and D if you were to try to obtain therapeutic amounts of EPA and DHA from cod liver oil. Supplementing with fish oils has been found to be entirely safe even for periods as long as 7 years and no significant adverse effects have been reported in hundreds of clinical trials using as much as 18 grams/day of fish oils. REFERENCES Simopoulos, Artemis. Omega-3 fatty acids in health and disease and in growth and development. American Journal of Clinical Nutrition, Vol. 54, 1991, pp. 438-63 Pepping, Joseph. Omega-3 essential fatty acids. American Journal of Health-System Pharmacy, Vol. 56, April 15, 1999, pp. 719-24 Uauy-Dagach, Ricardo and Valenzuela, Alfonso. Marine oils: the health benefits of n-3 fatty acids. Nutrition Reviews, Vol. 54, November 1996, pp. S102-S108 Connor, William E. Importance of n-3 fatty acids in health and disease. American Journal of Clinical Nutrition, Vol. 71 (suppl), January 2000, pp. 171S-75S DiGiacomo, Ralph A. , et al. Fish-oil Dietary Supplementation in Patients with Raynaud's Phenomenon: A Double-Blind, Controlled, Prospective Study. 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The influence of a fish oil high in docosahexaenoic acid on plasma lipoprotein and vitamin E concentrations and haemostatic function in healthy male volunteers. British Journal of Nutrition, Vol 68, July 1992, pp. 163-73 This article was first published in International Health News Issue 103, July 2000 _________________ JoAnn Guest mrsjo- www.geocities.com/mrsjoguest/Diets AIM Barleygreen " Wisdom of the Past, Food of the Future " http://www.geocities.com/mrsjoguest/Diets.html Start your day with - make it your home page Quote Link to comment Share on other sites More sharing options...
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