Guest guest Posted April 4, 2009 Report Share Posted April 4, 2009 The story about Asparagus has been doing the rounds on the Internet since 2006. Snopes, a site where the truth or falsehood about Internet stories is investigated, looked at the evidence and decided it was "indeterminate". Regarding the effect of cooking on glutathione, in most cases, the glutathione content of vegetables is destroyed by cooking. The table below gives an idea of how much is destroyed (the figures are in mg/100gm of the food: Apples Uncooked: 21.0 mg Cooked: 0.0 mg Carrots Uncooked: 74.6 mg Cooked: 0.0 mg Grapefruit Uncooked: 70.6 mg Cooked: 0.0 mg Spinach Uncooked: 166 mg Cooked: 27.1 mg Tomatoes Uncooked: 169 mg Cooked: 0.0 mgAsparagus (4) Uncooked: 28.3 mg Cooked: N/A mg Avocado (4) Uncooked: 27.7 mg Cooked: N/A mg Purslane (4) Uncooked: 14.81 mg Cooked: N/A mg Although the figures for the last 3 were not given in the Internet article, Asparagus seems to be an exception to the rule. In the "Handbook of Anti-oxidants" by Enrique Cadenas and Lester Packer the figures are given as follows: Uncooked: 28.3mg Cooked: 26.3mg The anti-cancer effect of the Asparagus is mainly because of the high Glutathione content. Glutathione seems to be essential to restore the mitochondrial "switch" which is responsible for the change of normal differentiated cells to undifferentiated cancer cells. That is why I recommend the N-Acetyl Cysteine (NAC) in my protocol. The Cysteine is a pre-cursor to Glutathione and it allows the body to synthesize its own. Some doctors are against the use of additional glutathione on the assumption that one can induce the killing of cancer cells by cutting off their ATP production in which Glutathione has an essential role. Natural healers may suggest Paw-Paw extract, Graviola, and similar plant products (as well as Cantron and Protocel) for the same reason. In my opinion, this suggestion can only be entertained in a limited number of cases and the trade-off is that if the timing is not right, it may expedite the formation of metastases. The argument is as follows: All cells require energy in the form of Adenosine Triphosphate (ATP). This substance cannot be stored in the cells and at any stage we have enough to last for about 3 to 5 seconds. It is thus a continuous process. A few billion years ago, before there was oxygen in the atmosphere, primitive cells (eukaryotes) evolved the process of producing ATP energy without the use of oxygen by a process of glycolysis. Later on in the evolutionary process, when oxygen became part of the atmosphere, certain types of bacteria evolved a much more efficient way of producing ATP by utilizing oxygen through a process known as oxidative phosphorylation (OXPHOS). This new process was roughly 20 times more efficient than the glycolysis process. Roughly two billion years ago, these bacteria and the original eukaryotes fused into a symbiotically functioning and more complex cell system. Researchers now acknowledge that the bacterial component of cells is the cellular mitochondria. All cells, with the exclusion of red blood cells, can have thousands of the mitochondria. These new "symbionts" can switch between the two systems of ATP production, depending on the demands of the cells. During the fetal stage and repair of cell damage, it switches to the ATP production from glucose in the cytoplasm of the dell. During the cell differentiation stage, it switches to the OXPHOS system of oxidative ATP production in the cell mitochondria. The switching system itself is controlled by an intricate signaling system that depends on the permeability of the mitochondrial membrane and its influence on the Ca 2+ cycle, the electrical charge across the mitochondrial membrane and other factors. All these factors, in turn, are modulated by the so-called thiol pool of which glutathione is the most important component.When body cells are under oxidative or nitrosative stresses caused by environmental factors and/or life style, the thiol pool normally gets depleted and, with it, the ability of the mitochondria to produce ATP through the OXPHOS system. As a defensive measure, the mitochondrial switch puts the cells into the more primitive way of survival by reverting to the much less efficient enzymatic production of ATP in the cytoplasm. If the aforementioned stresses are chronic, the switch remains in this position and we call the condition "cancer" - identified by the undifferentiated division of cells.If the cut-off of ATP production by the OXPHOS system is sudden, the cells will die and the process is known as 'necrosis' or sudden cell death. If it is more gradual, the affected cells can 'commit suicide', a process know as 'apoptosis'. Treatments like the acetogenins in Paw-Paw extract, Graviola and similar plants, (as well as Cantron and Protocel) have the effect of reducing the ATP in all cells and it is then hoped that the described 'apoptosis' of cancer cells will take place. Because of the fact that the ATP production of ALL cells is reduced, one can feel very tired when using the above supplements.Unfortunately, the apoptosis of cancer cells will only take place if the mitochondrial membrane is still permeable and the CA 2+ cycle is still working. In all advanced cancers, this permeability is blocked as part of the defense mechanism of cells and apoptosis CANNOT take place, however much Paw-Paw extract or any ATP reducing supplements one takes. One can thus see that the treatment (of reducing ATP and/or glutathione) will work in some cases where the cancer is at a stage where the mitochondrial switch is still fluctuating between the two methods of ATP production. This 'window of opportunity' is relatively short and when metastases have appeared, it is normally a sign that the mitochondrial membranes are blocked. The only alternative is then to reactivate the mitochondrial switch by getting rid of the oxidative and nitrosative stresses, and by topping up the depleted glutathione. Nothing else will work. Marc Swanepoel Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2009 Report Share Posted April 5, 2009 Marc Good info I have been getting Glutation shots twice a week 100 MG's and a occational drip 600 MG's when I can afford it. It does help. Also take lots of L-glutamine. awareness.investigation.knowledge.potential.motivation.action.patience.results Duke Dallas - Texas info --- On Sat, 4/4/09, Marc Swanepoel - PhD <marcswan wrote: Marc Swanepoel - PhD <marcswan Asparagus, Cancer and Glutathioneoleander soup Date: Saturday, April 4, 2009, 4:10 PM The story about Asparagus has been doing the rounds on the Internet since 2006. Snopes, a site where the truth or falsehood about Internet stories is investigated, looked at the evidence and decided it was "indeterminate" . Regarding the effect of cooking on glutathione, in most cases, the glutathione content of vegetables is destroyed by cooking. The table below gives an idea of how much is destroyed (the figures are in mg/100gm of the food: Apples Uncooked: 21.0 mg Cooked: 0.0 mg Carrots Uncooked: 74.6 mg Cooked: 0.0 mg Grapefruit Uncooked: 70.6 mg Cooked: 0.0 mg Spinach Uncooked: 166 mg Cooked: 27.1 mg Tomatoes Uncooked: 169 mg Cooked: 0.0 mgAsparagus (4) Uncooked: 28.3 mg Cooked: N/A mg Avocado (4) Uncooked: 27.7 mg Cooked: N/A mg Purslane (4) Uncooked: 14.81 mg Cooked: N/A mg Although the figures for the last 3 were not given in the Internet article, Asparagus seems to be an exception to the rule. In the "Handbook of Anti-oxidants" by Enrique Cadenas and Lester Packer the figures are given as follows: Uncooked: 28.3mg Cooked: 26.3mg The anti-cancer effect of the Asparagus is mainly because of the high Glutathione content. Glutathione seems to be essential to restore the mitochondrial "switch" which is responsible for the change of normal differentiated cells to undifferentiated cancer cells. That is why I recommend the N-Acetyl Cysteine (NAC) in my protocol. The Cysteine is a pre-cursor to Glutathione and it allows the body to synthesize its own. Some doctors are against the use of additional glutathione on the assumption that one can induce the killing of cancer cells by cutting off their ATP production in which Glutathione has an essential role. Natural healers may suggest Paw-Paw extract, Graviola, and similar plant products (as well as Cantron and Protocel) for the same reason. In my opinion, this suggestion can only be entertained in a limited number of cases and the trade-off is that if the timing is not right, it may expedite the formation of metastases. The argument is as follows: All cells require energy in the form of Adenosine Triphosphate (ATP). This substance cannot be stored in the cells and at any stage we have enough to last for about 3 to 5 seconds. It is thus a continuous process. A few billion years ago, before there was oxygen in the atmosphere, primitive cells (eukaryotes) evolved the process of producing ATP energy without the use of oxygen by a process of glycolysis. Later on in the evolutionary process, when oxygen became part of the atmosphere, certain types of bacteria evolved a much more efficient way of producing ATP by utilizing oxygen through a process known as oxidative phosphorylation (OXPHOS). This new process was roughly 20 times more efficient than the glycolysis process. Roughly two billion years ago, these bacteria and the original eukaryotes fused into a symbiotically functioning and more complex cell system. Researchers now acknowledge that the bacterial component of cells is the cellular mitochondria. All cells, with the exclusion of red blood cells, can have thousands of the mitochondria. These new "symbionts" can switch between the two systems of ATP production, depending on the demands of the cells. During the fetal stage and repair of cell damage, it switches to the ATP production from glucose in the cytoplasm of the dell. During the cell differentiation stage, it switches to the OXPHOS system of oxidative ATP production in the cell mitochondria. The switching system itself is controlled by an intricate signaling system that depends on the permeability of the mitochondrial membrane and its influence on the Ca 2+ cycle, the electrical charge across the mitochondrial membrane and other factors. All these factors, in turn, are modulated by the so-called thiol pool of which glutathione is the most important component.When body cells are under oxidative or nitrosative stresses caused by environmental factors and/or life style, the thiol pool normally gets depleted and, with it, the ability of the mitochondria to produce ATP through the OXPHOS system. As a defensive measure, the mitochondrial switch puts the cells into the more primitive way of survival by reverting to the much less efficient enzymatic production of ATP in the cytoplasm. If the aforementioned stresses are chronic, the switch remains in this position and we call the condition "cancer" - identified by the undifferentiated division of cells.If the cut-off of ATP production by the OXPHOS system is sudden, the cells will die and the process is known as 'necrosis' or sudden cell death. If it is more gradual, the affected cells can 'commit suicide', a process know as 'apoptosis'. Treatments like the acetogenins in Paw-Paw extract, Graviola and similar plants, (as well as Cantron and Protocel) have the effect of reducing the ATP in all cells and it is then hoped that the described 'apoptosis' of cancer cells will take place. Because of the fact that the ATP production of ALL cells is reduced, one can feel very tired when using the above supplements.Unfortunately, the apoptosis of cancer cells will only take place if the mitochondrial membrane is still permeable and the CA 2+ cycle is still working. In all advanced cancers, this permeability is blocked as part of the defense mechanism of cells and apoptosis CANNOT take place, however much Paw-Paw extract or any ATP reducing supplements one takes. One can thus see that the treatment (of reducing ATP and/or glutathione) will work in some cases where the cancer is at a stage where the mitochondrial switch is still fluctuating between the two methods of ATP production. This 'window of opportunity' is relatively short and when metastases have appeared, it is normally a sign that the mitochondrial membranes are blocked. The only alternative is then to reactivate the mitochondrial switch by getting rid of the oxidative and nitrosative stresses, and by topping up the depleted glutathione. Nothing else will work. Marc Swanepoel Quote Link to comment Share on other sites More sharing options...
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