Tony --NAC-OLEANDER PROTOCOL questions??

November 12, 2009

I have an appointment with a new alternative doctor tomorrow. I'd love to ask him about this but he's not going to know the answer. Can you give me some guidance? Thanks. Jan--- On Tue, 11/10/09, fehmiunal <unal.fehmi wrote:

fehmiunal <unal.fehmi NAC-OLEANDER PROTOCOL questions??oleander soup Date: Tuesday, November 10, 2009, 8:24 PM

Following excerpt is from a paper studying oleander, explaining its mechanism of effect against cancer cells. It is explained here that oleander needs oxygen species for anticancer effects, and NAC inhibits formation of -oleander induced- oxygen species. that means it is not beneficial to use antioxidants during oleander treatment. NAC stops oleander killing cancer cells. it increases gluthation and serves as antioxidant. I wonder why it is favored in this group to use NAC as it interferes whith oleander? any ideas?best wishes to all,excerpt: J Exp Ther Oncol. 2006;5(3):167- 81.Oleandrin-mediated oxidative stress in human melanoma cells.Newman RA, Yang P, Hittelman WN, Lu T, Ho DH, Ni D, Chan D, Vijjeswarapu M, Cartwright C, Dixon S, Felix E, Addington C.Department of Experimental Therapeutics, Univ. Texas M. D. Anderson Cancer Center, Houston, TX 77054, USA. rnewman (AT) mdanderson (DOT) orgWhile certain cardiac glycoside compounds such as oleandrin, bufalin and digitoxin are known to be associated with potent cytotoxicity to human tumor cells, the mechanisms by which this effect is produced are not clear. We now demonstrate that incubation of human malignant melanoma BRO cells with oleandrin results in a time-dependent formation of reactive oxygen species (ROS). Use of Mito-SOX and dihydroethidine dyes revealed the presence of oleandrin-mediated superoxide anions. Formation of superoxide anions correlated with a loss in cellular viability, proliferation and cellular defense mechanisms such as GSH content. Oleandrin also resulted in an unusual time-dependent mitochondrial condensation in BRO cells that could be blocked with use of N-acetyl cysteine (NAC). NAC

was also shown to block ROS formation and partially prevent oleandrin-mediated loss of cellular GSH. Taken as a whole, the data suggest that exposure of human tumor cells such as BRO to oleandrin results in the formation of superoxide anion radicals that mediate mitochondrial injury and loss of cellular GSH pools. These mechanisms play a role in cardiac glycoside mediated tumor cell injury. Conversely, incubation of NAC, a precursor to GSH, largely prevents oleandrin-mediated inhibition of proliferation and mitochondria structural changes.PMID: 16528968 [PubMed - indexed for MEDLINE]

November 12, 2009

hi,

I am sorry for the late response,for now I have nothing more about

oleander-antioxidant interaction. Reading this article, I noticed the conflict

but am not sophisticated about the issue. Just have concerns 'not to be a

tomfool' about my fathers cancer. if a herb-drug uses ROS to bomb out the

can-cells, using an antioxidant concurrently eventuate your missiles unarmed. I

am reading more right now. please let me know what your naturopath says.

best wishes,

November 12, 2009

Ha! He'd never heard of Oleander. He's going to read up on it. Jan--- On Thu, 11/12/09, fehmiunal <unal.fehmi wrote:

fehmiunal <unal.fehmi Re: Tony --NAC-OLEANDER PROTOCOL questions??oleander soup Date: Thursday, November 12, 2009, 11:35 AM

hi,I am sorry for the late response,for now I have nothing more about oleander-antioxidan t interaction. Reading this article, I noticed the conflict but am not sophisticated about the issue. Just have concerns 'not to be a tomfool' about my fathers cancer. if a herb-drug uses ROS to bomb out the can-cells, using an antioxidant concurrently eventuate your missiles unarmed. I am reading more right now. please let me know what your naturopath says. best wishes,