B Vitamins Help Normalize Juvenile Diabetes

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B Vitamins Help Normalize Juvenile Diabetes

 

 

B Vitamins Help Normalize Juvenile Diabetes

Tuesday, August 15, 2006 -

 

http://www.willner.com/article.aspx?artid=202

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--Research on B vitamins and children with diabetes type 1 has

revealed supplementation can normalize endothelial function, a

precursor of vascular disease, which begins early in juvenile

diabetes and is associated with folate status. Published in the July

issue of Pediatrics(118, 1:242-53, 2006), the study results showed

high-dose folate and vitamin B6 normalized endothelial dysfunction

in the children, an effect maintained for eight weeks.

 

The randomized, double-blind, placebo-controlled study involved

administration of folate (5 mg/d) and vitamin B6 (100 mg/d)--alone

and in combination--for eight weeks in 124 children with type 1

diabetes. Endothelial function, assessed as flow-mediated dilation

and glyceryltrinitrate-induced dilation with high-resolution

ultrasound of the brachial artery, was measured at baseline, at 2

and 4 hours after the first dose (n = 35), and at 4 and 8 weeks of

treatment (n = 122). From baseline to 8 weeks, flow-mediated

dilation improved with folate from 2.6% +/- 4.3% (mean +/- SD) to

9.7% +/- 6.0%, with vitamin B6 from 3.5% +/- 4.0% to 8.3% +/- 4.2%,

and with folate/vitamin B6 from 2.8% +/- 3.5% to 10.5% +/- 4.4%.

 

This improvement in flow-mediated dilation occurred within 2 hours

and was maintained at 8 weeks for each treatment. Flow-mediated

dilation in the placebo group, and glyceryltrinitrate-induced

dilation in all groups, did not change. Increases in serum folate,

red cell folate, and serum vitamin B6 levels related to increases in

flow-mediated dilation. Improvement in flow-mediated dilation was

independent of changes in total plasma homocysteine, glucose,

hemoglobin A1c, and high-sensitivity C-reactive protein levels.

Baseline red cell folate levels and baseline diastolic blood

pressure were related inversely to improvement in flow-mediated

dilation. Serum triglyceride and low-density lipoprotein cholesterol

inversely related to baseline flow-mediated dilation.

The researchers concluded high-dose folate and vitamin B6 normalized

endothelial dysfunction in children with type 1 diabetes; and this

effect was maintained over 8 weeks, with no additional benefit from

combination treatment.

 

 

 

 

 

 

 

 

 

 

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