An intravascular immune response to Borrelia burgdorferi involves Kupffer cells

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An intravascular immune response to Borrelia

burgdorferi involves Kupffer cells,and iNKT cells

 

Nat Immunol. 2010 Apr;11(4):295-302. Epub 2010 Mar 14.

 

An intravascular immune response to Borrelia burgdorferi involves

Kupffer cells and iNKT cells.

 

Lee WY, Moriarty TJ, Wong CH, Zhou H, Strieter RM, van Rooijen N,

Chaconas G, Kubes P.

 

Department of Physiology & Pharmacology, University of Calgary,

Alberta, Canada.

 

Here we investigate the dynamics of the hepatic intravascular

immune response to a pathogen relevant to invariant natural

killer T cells (iNKT cells).

Immobilized Kupffer cells with highly ramified extended processes

into multiple sinusoids could effectively capture blood-borne,

disseminating Borrelia burgdorferi, creating a highly efficient

surveillance and filtering system.

After ingesting B. burgdorferi, Kupffer cells induced chemokine

receptor CXCR3-dependent clustering of iNKT cells. Kupffer cells

and iNKT cells formed stable contacts via the antigen-presenting

molecule CD1d, which led to iNKT cell activation. An absence of

iNKT cells caused B. burgdorferi to leave the blood and enter the

joints more effectively. B. burgdorferi that escaped Kupffer

cells entered the liver parenchyma and survived despite Ito cell

responses. Kupffer cell-iNKT cell interactions induced a key

intravascular immune response that diminished the dissemination

of B. burgdorferi.

 

http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pu

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PMID: 20228796 [PubMed - in process]