Elk velvet antler for the treatment of osteoarthrosis in dogs.

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Hi All,

 

See this.

 

Phil

 

ElkMed Group: Consider inviting m.moreau to the

group?

 

 

Moreau M, Dupuis J, Bonneau NH, Lecuyer M. Clinical evaluation of a

powder of quality elk velvet antler for the treatment of osteoarthrosis in

dogs. Can Vet J. 2004 Feb;45(2):133-9. Companion Animal Research

Group, Faculte de Medecine veterinaire, Universite de Montreal, 3200

Sicotte, P.O. Box 5000, St-Hyacinthe Quebec J2S 7C6.

m.moreau A powder of quality elk velvet antler (QEVA)

was evaluated on client-owned dogs with osteoarthrosis (OA) in a

clinical, double-blind, and placebo-controlled study. Thirteen dogs

received a placebo for 30 days and then QEVA for 60 days. Twenty-five

other dogs received QEVA for 60 days. Gait analysis measured with a

force plate, clinical signs assessed by an orthopedic surgeon,

performances in daily life activities and vitality assessed by the owners,

and complete blood analyses were obtained at days 0, after 30 days of

placebo and/or 60 days of QEVA. On placebo, the 13 dogs did not show

significant improvement (P < 0.05); however, their gait, their

performances in daily life activities, and their vitality were significantly

improved on QEVA, based on changes in values exceeding those

observed when placebo was administered. The 25 dogs on QEVA for 60

days showed similar improvements. No clinical changes were revealed

on blood analyses. Administration of QEVA was effective in alleviating

the condition in arthritic dogs. PMID: 15025149 [PubMed - indexed for

MEDLINE]

 

Zhou QL, Guo YJ, Wang LJ, Wang Y, Liu YQ, Wang Y, Wang BX.

Velvet antler polypeptides promoted proliferation of chondrocytes and

osteoblast precursors and fracture healing. Zhongguo Yao Li Xue Bao.

1999 Mar;20(3):279-82. Research Centre of New Drug, Changchun

College of Traditional , China. AIM: To study the

effects of velvet antler (VA) total polypeptides (VATP) and VA

polypeptides, VAP-A, VAP-B, and VAP-C on proliferation of

chondrocytes and osteoblast precusors. METHODS: Chondrocytes

(rabbit and human fetus) and osteoblast precusors (chick embryo) were

incubated in the culture medium containing VATP or VAP-A, VAP-B,

and VAP-C. [3H]TdR incorporation into DNA was measured. Fracture

healing-promoting action of VATP was determined in rats. RESULTS:

VATP 50-200 mg.L-1 and VAP-B 12.5, 25, and 50 mg.L-1 showed most

marked proliferation-promoting activity for rabbit costed chondrocytes

and increased incorporation of [3H]TdR from (73 +/- 9) Bq (control

group) to (272 +/- 55), (327 +/- 38), and (415 +/- 32) Bq, respectively (P

< 0.01). The activity of VAP-A was weaker than that of VAP-B, and

VAP-C had no activity. VATP 10 and 20 mg.kg-1 by local injection into

the cross-section fracture area accelerated healing of radial fracture.

The healing rate of VATP-treated group was higher (75%) than that of

control group (25%) (P < 0.05). CONCLUTION: VATP accelerated

fracture healing by stimulating proliferation of chondrocytes and

osteoblast precursors. PMID: 10452108 [PubMed - indexed for

MEDLINE]

 

 

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