Effect of Testosterone on Metabolic Syndrome

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Effect of Testosterone on Metabolic Syndrome

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Another study suggests testosterone therapy can improve metabolic syndrome,

decreasing the risk of diabetes and heart disease. It also helped erectile

dysfunction. The assumption that treatment with testosterone is adequate when

it simply brings testosterone blood levels into the normal range is also not

valid. Some testosterone dependent functions require higher plasma levels than

others, and, moreover, these thresholds differ among men. Testosterone

levels should be optimized within the normal range.

Andrologia. 2008 Feb;40(1):44-8.

Effects of Testosterone Gel Followed by Parenteral Testosterone Undecanoate

on Sexual Dysfunction and on Features of the Metabolic Syndrome

Saad F, Gooren L, Haider A, Yassin A

The effects of administration of testosterone (T) gel, resulting in plasma T

levels in the low range of reference values, followed by testosterone

undecanoate (TU), producing plasma T levels in the mid-normal range, were

measured

in 27 hypogonadal men aged 47-74 years. T gel had positive effects on the

International Index of Erectile Function, the Aging Males' Symptoms Scale and

International Prostate Symptoms Score and on the metabolic syndrome. The

improvement was larger when TU was administered and plasma T levels were

higher.

The reduction in waist circumference and plasma cholesterol were larger with TU

than with T gel, while the increases in plasma high-density lipoprotein and

sex hormone binding globulin (an indicator of the severity of the metabolic

syndrome) were larger with TU than with T gel. Both T gel and TU appeared safe

on prostate parameters. Plasma haemoglobin and haematocrit were elevated but

remained in the normal range.

Reference:

PMID: 18211301 [PubMed - in process] ]