Low levels of magnesium & zinc associated with FM pain, fatigue levels

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Low levels of magnesium & zinc associated with FM pain, fatigue levels.

 

Levels of one correlate with number of tender points; and levels of the

other with fatigue severity. But which comes first, symptom or deficiency?

 

The relationship between serum trace element levels and clinical parameters

in patients with Fibromyalgia - Source: Rheumatology International, May 22,

2008

_http://www.immunesupport.com/library/showarticle.cfm?id=8880 & T=CFIDS_FM & B1=EM

052808F_

(http://www.immunesupport.com/library/showarticle.cfm?id=8880 & T=CFIDS_FM & B1=EM05\

2808F)

 

by OF Sendur, et al.

ImmuneSupport.com

 

05-23-2008

 

 

 

(http://www.immunesupport.com/library/ad.cfm?ad_imp_id=8367652 & redir=2 & article_i\

d=8880 & client_id=1)

We examined the association between serum [in the blood] trace elements and

clinical findings such as number of sensitive tender points, severity of

fatigue, and functional status in patients with Fibromyalgia (FM).

Thirty-two patients diagnosed as having FM according to the ACR 1990

criteria and 32 normal healthy controls (NHC) were included in this study.

The demographic data, disease duration, number of tender points and

accompanying symptoms (fatigue, sleep disorders, headache, paresthesia,

irritable

bowel syndrome, sicca symptoms, Raynaud's phenomena) of the patients were

noted.

Visual analog scale (10 cm) was implemented to estimate daily severity of

pain and fatigue. Fibromyalgia impact questionnaire was used for functional

assessment.

Serum selenium (mug/dL) and serum zinc (mug/dL) levels were measured by

atomic absorption spectrometer. Serum magnesium (mmol/L) level was measured by

the original kits of Abbott Aeroset auto-analyzer. The mean age of patients in

FM group and NHC were calculated as 42.9 (SD = 7.7) years and 41.3 (SD = 9.7)

years, respectively.

Serum levels of zinc (P = 0.001) and magnesium (P = 0.002) were

significantly decreased by FM groups, whereas there was no considerable

difference with

selenium levels of both groups (P > 0.05).

Association between serum zinc level and number of tender points (P = 0.008)

and that between fatigue and magnesium level (P = 0.003) was found as

meaningful.

According to the results of this study, it was asserted that serum magnesium

and zinc levels may play an important role in the pathophysiology of FM.

Source: Rheumatology International, May 22, 2008. [Epub ahead of print]

PMID: 18496697, by Sendur OF, Tastaban E, Turan Y, Ulman C. Department of

Physical Medicine and Rehabilitation, Adnan Menderes University Medicine School

Hospital, Aydin, Turkey.