Medication-induced mitochondrial damage and disease.

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Reference: *Medication and ME/CFS?*

By Margaret Williams

Help ME Circle, 29 August 2008;

Co-Cure:

_http://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind0808e & L=co

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Mol Nutr Food Res. 2008 Jul;52(7):780-8.

 

 

Links Medication-induced mitochondrial damage and disease.

 

 

Neustadt J, Pieczenik SR. Montana Integrative Medicine, Bozeman, MT 59718,

USA. _drneustadt_ (drneustadt)

 

 

Since the first mitochondrial dysfunction was described in the 1960s, the

medicine has advanced in its understanding the role mitochondria play in health

and disease.

 

Damage to mitochondria is now understood to play a role in the pathogenesis

of a wide range of seemingly unrelated disorders such as schizophrenia,

bipolar disease, dementia, Alzheimer's disease, epilepsy, migraine headaches,

strokes, neuropathic pain, Parkinson's disease, ataxia, transient ischemic

attack, cardiomyopathy, coronary artery disease, chronic fatigue syndrome,

fibromyalgia, retinitis pigmentosa, diabetes, hepatitis C, and primary biliary

cirrhosis.

 

Medications have now emerged as a major cause of mitochondrial damage, which

may explain many adverse effects. All classes of psychotropic drugs have

been documented to damage mitochondria, as have statin medications, analgesics

such as acetaminophen, and many others.

 

While targeted nutrient therapies using antioxidants or their precursors (e.

g., N-acetylcysteine) hold promise for improving mitochondrial function,

there are large gaps in our knowledge.

 

The most rational approach is to understand the mechanisms underlying

mitochondrial damage for specific medications and attempt to counteract their

deleterious effects with nutritional therapies.

 

This article reviews our basic understanding of how mitochondria function

and how medications damage mitochondria to create their occasionally fatal

adverse effects.

 

 

PMID: 18626887 [PubMed - indexed for MEDLINE]

 

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