Breast Cancer iodine supplements

[Guest guest]

Hi All, & Chris

 

> As a side note, it has been suggested that virtually all women with

> breat problems are low in iodine. Breast tissue supposedly holds

> more iodine than any tissue other than thyriod. You may choose to do

> some reading on a product called iodoral. [Chris]

 

Trace-element research [in ruminants] was my main professional

specialty for more than 40 years. Excessive intake of iodine can cause

thyrotoxicosis. A supplement of 13mg I/d (as advised on the Iodoral

site) is far too high for humans. IMO, it should be between 1 and 4mg/d

and should not exceed 8mg I/d unless advised by medical specialists in

the field.

 

Briefly, PII [plasma inorganic iodine] is the best blood test of current

iodine nutrition in animals. Using that test, we established that the

optimum I supplementr for Irish cattle is 30-60mg I/600 kg lw.

 

See: http://homepage.eircom.net/~progers/bldlab.htm#milk

http://homepage.eircom.net/~progers/3control.htm#idef

http://homepage.eircom.net/~progers/abattoir.htm

http://homepage.eircom.net/~progers/iodsupp.htm

 

4. I LEVELS IN SAMPLES OF IRISH BULK-TANK MILK

 

Low I levels in bovine milk indicate I deficiency in the diet. Carryover of

dietary I to milk is variable, but milk I levels increase with intake. High

levels in milk may indicate excessive amounts of dietary I, or

contamination of milk by I-based teat dips, or disinfectants on the farm,

in transit to the milk depot, or during milk processing.

 

I in cattle feed is mainly iodide, absorbed more or less totally from all

levels of the digestive tract. Very little I appears in faeces and that which

does is organically bound. Other forms of inorganic I (for example

iodates) are reduced to iodide before absorption. Iodinated amino acids

are well absorbed as such, though slower than iodide. Ethylene-

diamine-dihydro-iodide (EDDI) is very highly absorbed. Recycling

(secretion in saliva, gastric juices etc) is a means of conserving I. Urine

is the main route of I excretion and increasing levels of I are secreted in

milk with increasing inputs of I (Underwood 1962).

 

However, milk products supply up to 50% or more of human dietary I

(as iodide) intake. High I intakes can cause thyrotoxicosis in humans.

The threat is greatest to infants fed large amounts of milk powder with

excessive levels of I. The American NRC recommends a maximum of

1000 ug (= 1mg) I/d as safe for adult humans.

 

From pre-1970 to 1978, milk I levels in American bulk-tanks increased

so that a daily intake of 500-1000 ml milk from some farms (1000-2000

ug/L) and 125-500 ml of heavily contaminated milk (2000-8000 ug/L)

would exceed the safe human adult dose (Hemken 1979).

 

There is great variation in the breakpoints used by different authors to

assess I status in bovine milk. As an index of bovine I supply, the

Grange Labs use:

 

MI level (ug/L) <25 25- 38 39- 50 51-300 301-400 >400

 

MI Status Very Low Low Marginal Normal High Very high

 

Between September 1992 and October 1995, 69 samples of milk from

farm bulk-tanks were tested for milk I levels. Some samples were

grossly deficient in I; others were from herds on an I supplement. The

mean milk I value was 139 (range 2-435, sd 108) ug I/L. On average,

adults would have to drink >7 l milk/d to exceed the safe level of I from

that source. The data indicate no serious national problem with I levels

in Irish bulk-tank milk.

 

Teagasc recommends a maximum supplement of 60 mg I/cow/d but

EU Feed Regulations allow up to 165 mg/cow/d. Contamination by I in

teat dips and disinfectants, or from excessive use of I supplements in

dairy herds, can increase milk I levels. I can also enter milk after the

bulk-tank. Non-dietary I (teat dips, disinfectants, post-farm I

contamination) is a greater source of I in milk than is dietary I. Hemken

(1979) cites several studies that suggest that iodophor use increases

mean MI level by 35-390 ug/L between farms or 174-285 ug/L between

studies. See: http://homepage.eircom.net/~progers/i_report.htm

 

Best regards,

 

[Guest guest]

phil, so is id supplementation a good idea at all? well, x for us soymilk

imbibers. lynn

 

[] wrote:

Hi All, & Chris

 

> As a side note, it has been suggested that virtually all women with

> breat problems are low in iodine. Breast tissue supposedly holds

> more iodine than any tissue other than thyriod. You may choose to do

> some reading on a product called iodoral. [Chris]

 

Trace-element research [in ruminants] was my main professional

specialty for more than 40 years. Excessive intake of iodine can cause

thyrotoxicosis. A supplement of 13mg I/d (as advised on the Iodoral

site) is far too high for humans. IMO, it should be between 1 and 4mg/d

and should not exceed 8mg I/d unless advised by medical specialists in

the field.

 

Briefly, PII [plasma inorganic iodine] is the best blood test of current

iodine nutrition in animals. Using that test, we established that the

optimum I supplementr for Irish cattle is 30-60mg I/600 kg lw.

 

See: http://homepage.eircom.net/~progers/bldlab.htm#milk

http://homepage.eircom.net/~progers/3control.htm#idef

http://homepage.eircom.net/~progers/abattoir.htm

http://homepage.eircom.net/~progers/iodsupp.htm

 

4. I LEVELS IN SAMPLES OF IRISH BULK-TANK MILK

 

Low I levels in bovine milk indicate I deficiency in the diet. Carryover of

dietary I to milk is variable, but milk I levels increase with intake. High

levels in milk may indicate excessive amounts of dietary I, or

contamination of milk by I-based teat dips, or disinfectants on the farm,

in transit to the milk depot, or during milk processing.

 

I in cattle feed is mainly iodide, absorbed more or less totally from all

levels of the digestive tract. Very little I appears in faeces and that which

does is organically bound. Other forms of inorganic I (for example

iodates) are reduced to iodide before absorption. Iodinated amino acids

are well absorbed as such, though slower than iodide. Ethylene-

diamine-dihydro-iodide (EDDI) is very highly absorbed. Recycling

(secretion in saliva, gastric juices etc) is a means of conserving I. Urine

is the main route of I excretion and increasing levels of I are secreted in

milk with increasing inputs of I (Underwood 1962).

 

However, milk products supply up to 50% or more of human dietary I

(as iodide) intake. High I intakes can cause thyrotoxicosis in humans.

The threat is greatest to infants fed large amounts of milk powder with

excessive levels of I. The American NRC recommends a maximum of

1000 ug (= 1mg) I/d as safe for adult humans.

 

From pre-1970 to 1978, milk I levels in American bulk-tanks increased

so that a daily intake of 500-1000 ml milk from some farms (1000-2000

ug/L) and 125-500 ml of heavily contaminated milk (2000-8000 ug/L)

would exceed the safe human adult dose (Hemken 1979).

 

There is great variation in the breakpoints used by different authors to

assess I status in bovine milk. As an index of bovine I supply, the

Grange Labs use:

 

MI level (ug/L) <25 25- 38 39- 50 51-300 301-400 >400

 

MI Status Very Low Low Marginal Normal High Very high

 

Between September 1992 and October 1995, 69 samples of milk from

farm bulk-tanks were tested for milk I levels. Some samples were

grossly deficient in I; others were from herds on an I supplement. The

mean milk I value was 139 (range 2-435, sd 108) ug I/L. On average,

adults would have to drink >7 l milk/d to exceed the safe level of I from

that source. The data indicate no serious national problem with I levels

in Irish bulk-tank milk.

 

Teagasc recommends a maximum supplement of 60 mg I/cow/d but

EU Feed Regulations allow up to 165 mg/cow/d. Contamination by I in

teat dips and disinfectants, or from excessive use of I supplements in

dairy herds, can increase milk I levels. I can also enter milk after the

bulk-tank. Non-dietary I (teat dips, disinfectants, post-farm I

contamination) is a greater source of I in milk than is dietary I. Hemken

(1979) cites several studies that suggest that iodophor use increases

mean MI level by 35-390 ug/L between farms or 174-285 ug/L between

studies. See: http://homepage.eircom.net/~progers/i_report.htm

 

Best regards,