Migu Pian [Densify Bone Tabs] to treat osteoporosis

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Hi All,

 

See this:

 

Dai Y, Shen L. [Effects of Migu Pian [Densify Bone Tablet] on bone

mineral density, serum matrix metalloproteinase-2 level and bone

metabolic markers in postmenopausal osteoporosis] [Article in

Chinese] Zhongguo Zhong Yao Za Zhi. 2007 Nov;32(22):2409-12.

Department of Traditional , Union Hospital of

Huazhong Science and Technology University, Wuhan 430022, China.

daiyifreeman OBJECTIVE: To study the effects of Migu

tablet(MG) on bone mineral density (BMD), serum matrix

metalloproteinase-2 (MMP-2) and bone metabolic markers in Chinese

postmenopausal women. METHOD: According to the criteria of

osteoporosis, 192 Chinese postmenopausal female of the aged 55-62

were randomized into 4 groups: normal group, Migu tablet (MG) group,

Xianling Gubao Capsule (XLGB) group and Leli group. The serum MMP-2,

bone alkaline phosphates (sBAP), osteocalcin (sOC), bone cross-linked

C-telopeptides of type I collagen (sCTx) and urine bone cross-linked

N-telopeptides of type I collagen (uNTx) were measured using ELISA.

BMD were measured using dual energy X-ray absorptiometry before and

after medication at 12 and 24 weeks. RESULT: After treatment, the

values of BMD were significantly higher in MG and XLGB groups

separately, otherwise lower in Leli and normal control groups. At the

same time, serum MMP-2, sCTx, uNTx/Cr concentrations were

significantly lower and sBAP, sOC concentrations were higher, but the

concentrations in Leli and normal control groups were basically same

to the value of before treatment. CONCLUSION: The effects of MG

tablet to treat the PMO were notable, just same to XLGB. But Leli

[calcium tablet] cannot play a role in the treatment of osteoporosis

and do not prevent the loss of bone. Publication Types: English

Abstract Randomized Controlled Trial Research Support, Non-U.S. Gov't

PMID: 18257271 [PubMed - indexed for MEDLINE]

 

PHIL´S NOTES, translated from http://tinyurl.com/c88h4h and other

sources:

 

Migu Pian (Densify Bone Tablet); composition: Duzhong 12g; Hetaorou /

Hutaorou 12g; Buguzhi 12g; Yinyanghuo 12g; Gandihuang 12g; Niuxi

(Huai) 12g; Dose: 5 X 600mg Tabs BID for 3 months; Formula can Enrich

Yinxu + Engender Qi, Aid Yangxu + Aid KI / Transform Water, Densify

Bone + Engender Marrow for Adaptation Disease / Stress Pattern,

osteoporosis, KI Xu loin + back pain; Formula is based on ancient

recipe Qing'e Wan (Jade Lady Pills, viz Duzhong, Hetaorou, Buguzhi);

in TCM, " KI Governs Bone " ; Qing'e Wan can Tone KI + Strengthen Sinew

+ Bone, Govern Xue Vessels, Darken beard + hair, Nourish Complexion

(face) colour to Tx KI Qi Xu + debility, low back pain as if fit to

break / fracture, difficulty rising / lying down, inhibited bending

forward / backward, difficulty changing position [from side to side

in bed]; Migu Pian is augmented Qing'e Wan to Tx osteoporosis; to

Duzhong, Hetaorou, Buguzhi, it adds:

Yinyanghuo [Nourish Jing + Qi, Tone Loin + Knees to boost

calcification + bone formation in osteoporosis;

Gandihuang [Nourish Yin + Xue, Replenish Bone Marrow];

Huainiuxi [Tone SJM-SP-ST, Dispel Loin + Knee Bone pain for leg Wei-

Atrophy w inability to walk properly; Descend Qi-Xue [Lit: Draw

(conduct) Qi-Xue Downward];

 

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XLGB = Xianling Gubao Jiaonong [Epimedium Bone Protector / Preserver

Capsule w Xianlingpi / Yinyanghuo 1167g; Xuduan 167g; Danshen 83g;

Zhimu 83g; Buguzhi 83g; Shudi / Shengdi 83g; 3 X 500mg Caps BID for 4-

6 weeks / course / as prescribed; Tone KI + Strengthen HT, Erect Yang

(aphrodisiac / Tx impotence) + Free Bi-Impediment; Move Xue + Free

Luo; Strengthen Sinew + Bone; Antiosteoporosis; [Danshen: Rectify

Xue; Tone Xue; Move Xueyu; Vascular Aid; Cool Xue; Resolve Carbuncle;

Ease Pain + numbness; Ease Chest / Epigastrium Oppression dt Xueyu;

Anticoagulant; Brighten Eyes]; use in impotence w emissions~ night,

Sinew + Bone Wei-Atrophy + flaccidity, Chest Oppression / tightness +

dizziness, breath shortness + fatigue, Wind Damp (rheumatic) Bi-

Impediment w pain; sexual function flaccid impotence / ED w

emission~ night , CHD, Menopausal hypertension, Chest tightness,

breath shortness + Wind Damp Pattern (rheumatism); also in LV-KI

Insufficiency w Xueyu & Bi-Impediment of Luo / Xueyu w extravasation

causing osteoporosis / arthralgia, loin + spine ache + pain, feet +

knees pain / ache + weakness / flaccidity, fatigue / lassitude /

listlessness, loin + knees pain + weakness, dizziness / vertigo,

tinnitus, bone pain dt osteoprosis / traumatic injury / bone fracture

/ osteoarthritis / ischaemic bone necrosis; CI in severe Ganmao; ;

CI in pregnancy; AVOID raw / Cold / oily foods; CAUTION w history of

allergy; seek medical help if hypertension, CHD, diabetes, LV / KI

disease / other serious chronic diseases exist; Seek hospital care if

no improvement within 2 weeks;

 

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Leli [ www.cnm21.com/00new/list.asp?id=1845 ] is a non-prescription

Vitamin (C + D3) + Mineral supplement to boost bone metabolism & bone

formation; it has calcium + trace minerals chelated w amino acids to

enhance gut absorption + cellular Ca + trace mineral uptake; Vit D3

to promote absorption and utilization of calcium; Vit C and trace

elements to promote bone formation + enhanced bone function; Dose:

Adults: 1-2 tabs / d; children <6 years: 1 Tab / d; use to Px / Tx

various diseases dt calcium and mineral shortage esp osteoporosis,

rickets~ pediatric + hypocalcaemic neuralgia + muscle spasms; Can be

used as calcium and Vit D3 supplement in osteoporosis, pregnancy,

lactation & pediatric rickets; CI in KI DysFx / hypercalcaemia; CI in

cases on digitalis; CAUTION in HT-KI DysFx; may cause occasional ST

upset;

 

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Comparison of Herbs in & Actions of Xianling Gubao Jiaonang versus

Danling Bushen Jiaonang (Chinese Salvia + Hoelen Tone KI Capsule);

both capsules Tone KI, Strengthen Bone & Move Xue, but Danling Bugu

Capsule is better when pain & / S & Ss of SP Xu / SP DysFx are major

signs:

 

Formula + Action Xianling Gubao Jiaonang Danling Bugu Jiaonang

Tone KI Yinyanghuo, Shengdi, Zhimu Yinyanghuo, Shudi

Strengthen Bone Buguzhi, Xuduan Buguzhi, Gusuibu

Move Xue Danshen Danshen

Analgesic Ruxiang, Moyao, Xuejie, Zirantong

Strengthen SP Huangqi, Fuling

 

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Best regards,