No Evidence that Prozac causes bone fluorosis

[Guest guest]

Hi Alon, & All,

Alon wrote:

> Phil organofluorine compounds that are fluoroalkane based do not

> release F- under biological conditions because of their stability.

 

Thanks for pointing that out.

 

> are you aware of any reports of prozac causing skeletal fluorosis?

 

No.

 

Medline has one case history of a woman with fluorosis but the cause

was attributed to F ingestion from MASSIVE amounts of tea, rather

than from intermittent use of Prozac.:

 

Whyte MP, Totty WG, Lim VT, Whitford GM. Skeletal fluorosis from

instant tea. J Bone Miner Res. 2008 May;23(5):759-69. Div of Bone and

Mineral Diseases, Washington University School of Medicine at Barnes-

Jewish Hospital, St Louis, Missouri, USA. INTRODUCTION: Skeletal

fluorosis (SF) can result from prolonged consumption of well water

with >4 ppm fluoride ion (F(-); i.e., >4 mg/liter). Black and green

teas can contain significant amounts of F(-). In 2005, SF caused by

drinking 1-2 gallons of double-strength instant tea daily throughout

adult life was reported in a 52-yr-old woman. MATERIALS AND METHODS:

A 49-yr-old woman developed widespread musculoskeletal pains,

considered fibromyalgia, in her mid-30s. Additionally, she had

unexplained, increasing, axial osteosclerosis. She reported drinking

2 gallons of instant tea each day since 12 yr of age. Fluoxetine had

been taken intermittently for 5 yr. Ion-selective electrode

methodology quantitated F(-) in her blood, urine, fingernail and

toenail clippings, tap water, and beverage. RESULTS: Radiographs

showed marked uniform osteosclerosis involving the axial skeleton

without calcification of the paraspinal, intraspinal, sacrotuberous,

or iliolumbar ligaments. Minimal bone excrescences affected

ligamentous attachments in her forearms and tibias. DXA Z-scores were

+10.3 in the lumbar spine and +2.8 in the total hip. Her serum F(-)

level was 120 microg/liter (reference range, 20-80 microg/liter), and

a 24-h urine collection contained 18 mg F(-)/g creatinine (reference

value, <3). Fingernail and toenail clippings showed 3.50 and 5.58 mg

F(-)/kg (control means, 1.61 and 2.02, respectively; p(s) < 0.001).

The instant tea beverage, prepared as usual extra strength using tap

water with approximately 1.2 ppm F(-), contained 5.8 ppm F(-).

Therefore, the tea powder contributed approximately 35 mg of the 44

mg daily F(-) exposure from her beverage. Fluoxetine provided at most

3.3 mg of F(-) daily. CONCLUSIONS: SF from habitual consumption of

large volumes of extra strength instant tea calls for recognition and

better understanding of a skeletal safety limit for this modern

preparation of the world's most popular beverage. PMID: 18179362

[PubMed - indexed for MEDLINE]

 

Best regards,