Interstitial Pneumonia and Chinese medicine

[Guest guest]

Dear Shinjiro,

Great to hear from you again! Yes, drop me the article, and I'll look

over this info and get back to you with my feedback.

 

 

 

 

>Dear Z'ev:

>

>Once, Bob Damone asked me about " interstitial pneumonia and Xiao Chaihu Tang

>in Japan " .

>The first incident was reported in 1989. Since then, there were more than 80

>cases and 14 deaths reported in Japan. Japanese " NIH " (ko sei sho: Ministry

>of Health and Welfare) has prohibited the use of Xiao Chaihu Tang with

>Interferon. Currently, the doubtful drugs are listed as:

>Da Chaihu Tang, Chaihu Guizhi Ganjiang Tang, Liu Jun Zi Tang, Chai Po Tang,

>Chai Ling Tang, and Banxia Xie Xin Tang.

>I found an article about this in the July, 1999 issue of Japanese Journal

>of Oriental Medicine, which is published by the Japan Society for Oriental

>Medicine. (This organization is for MDs who practice Kanpo in Japan.)

>Here, I will copy the abstract of this article for you, because I thought

>you might be interested in it, too.

>According to this report, as you know well, Xiao Chaihu Tang and Banxia Xie

>Xin Tang are very similar. 5 ingredients are common. The researchers (Okada,

>and others) speculate that Huangqin (Scutellariae) is a problematic

>ingredient.

>The patho-mechanisms of drug induced interstitial pneumonia are generally

>speculated as occurring in two ways:

>1) The cytotoxicity due to anticarcinogens or immunosuppresives,

>2) Hypersensitivity against drugs.

>And Kanpo induced interstitial pneumonia is speculated as a case of 2), Type

>III or Type IV allergic reactions.

>In this report, they found stimulation of Th 1 type cellular immune

>activity.

>I hope you enjoy (?!) this report.

>Yours,

> Shinjiro

> " A Case of Hepatitis and Interstitial Pneumonia Induced by Hangeshashin-to*

>and Shosaiko-to** "

>*Banxia Xie Xin Tang (Pinellia Decoction to Drain the Epigastrium)

>**Xiao Chaihu Tang (Minor Bupleurum Decoction)

>Yumi Okada1), Kenji Watanabe2), Yukio Suzuki1), Kunihiko Suzuki2), Go Ito2),

>Akihiko Muranushi2), Shigeru Kuramochi3), Kanji Tsuchimoto1), Shogo

>Ishino2), Toshihiko Hanawa2)

>1) M.D.s, The Kitasato Institute Hospital

>2) M.D.s, Oriental Medicine Research Institute of the Kitasato

>3) M.D., Division of Diagnostic Pathology, School of Medicine Keio

>University

>Abstract: A 60-year-old male patient visited the Oriental Medicine Research

>Institute of the Kitasato on June 3 because of abdominal discomfort.

>Hangeshashin-to was administered to him and the abdominal discomfort was

>relieved. He continued to take Hangeshashin-to from June to August 1997. He

>had chills, high fever, and fatigue from August 3. He stopped

>Hangeshashin-to and took Sahosaiko for five days because of liver

>dysfunction. He was admitted to our hospital on August 14. Antibiotics and

>stronger neo-minophagen C were administered to him. A chest roentgenogram

>revealed a ground-glass shadow on the left upper lung, and Shosaiko-to was

>discontinued. The patient began to complain of dyspnea and had fine crackles

>on the chest. A chest roentgenogram and chest CT showed interstitial

>pneumonitis. Oral prednisolone therapy was started for hypoxemia and the

>patient improved. A drug lymphocytes stimulation test revealed that

>lymphocytes were stimulated by Shosaiko-to and its components, Saiko* and

>Ogon**.[* Radix Bupleuri (chaihu) ** Radix Scutellatiae (huangqin)] A chest

>roentgenogram just before ingesting Hangeshashin-to revealed the

>interstitial change of the lung. Taken all together, this patient suffered

>from drug-induced hepatitis and pneumonitis as a result of ingesting

>Hangeshashin-to and Shosaiko-to.

>Nihon Toyo Igaku Zasshi (Japanese Journal of Oriental Medicine), 50 (1),

>57-65, 1999

>

>

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[Guest guest]

Dear Z¹ev:

 

Once, Bob Damone asked me about ³interstitial pneumonia and Xiao Chaihu Tang

in Japan².

The first incident was reported in 1989. Since then, there were more than 80

cases and 14 deaths reported in Japan. Japanese ³NIH² (ko sei sho: Ministry

of Health and Welfare) has prohibited the use of Xiao Chaihu Tang with

Interferon. Currently, the doubtful drugs are listed as:

Da Chaihu Tang, Chaihu Guizhi Ganjiang Tang, Liu Jun Zi Tang, Chai Po Tang,

Chai Ling Tang, and Banxia Xie Xin Tang.

I found an article about this in the July, 1999 issue of Japanese Journal

of Oriental Medicine, which is published by the Japan Society for Oriental

Medicine. (This organization is for MDs who practice Kanpo in Japan.)

Here, I will copy the abstract of this article for you, because I thought

you might be interested in it, too.

According to this report, as you know well, Xiao Chaihu Tang and Banxia Xie

Xin Tang are very similar. 5 ingredients are common. The researchers (Okada,

and others) speculate that Huangqin (Scutellariae) is a problematic

ingredient.

The patho-mechanisms of drug induced interstitial pneumonia are generally

speculated as occurring in two ways:

1) The cytotoxicity due to anticarcinogens or immunosuppresives,

2) Hypersensitivity against drugs.

And Kanpo induced interstitial pneumonia is speculated as a case of 2), Type

III or Type IV allergic reactions.

In this report, they found stimulation of Th 1 type cellular immune

activity.

I hope you enjoy (?!) this report.

Yours,

Shinjiro

³A Case of Hepatitis and Interstitial Pneumonia Induced by Hangeshashin-to*

and Shosaiko-to**²

*Banxia Xie Xin Tang (Pinellia Decoction to Drain the Epigastrium)

**Xiao Chaihu Tang (Minor Bupleurum Decoction)

Yumi Okada1), Kenji Watanabe2), Yukio Suzuki1), Kunihiko Suzuki2), Go Ito2),

Akihiko Muranushi2), Shigeru Kuramochi3), Kanji Tsuchimoto1), Shogo

Ishino2), Toshihiko Hanawa2)

1) M.D.s, The Kitasato Institute Hospital

2) M.D.s, Oriental Medicine Research Institute of the Kitasato

3) M.D., Division of Diagnostic Pathology, School of Medicine Keio

University

Abstract: A 60-year-old male patient visited the Oriental Medicine Research

Institute of the Kitasato on June 3 because of abdominal discomfort.

Hangeshashin-to was administered to him and the abdominal discomfort was

relieved. He continued to take Hangeshashin-to from June to August 1997. He

had chills, high fever, and fatigue from August 3. He stopped

Hangeshashin-to and took Sahosaiko for five days because of liver

dysfunction. He was admitted to our hospital on August 14. Antibiotics and

stronger neo-minophagen C were administered to him. A chest roentgenogram

revealed a ground-glass shadow on the left upper lung, and Shosaiko-to was

discontinued. The patient began to complain of dyspnea and had fine crackles

on the chest. A chest roentgenogram and chest CT showed interstitial

pneumonitis. Oral prednisolone therapy was started for hypoxemia and the

patient improved. A drug lymphocytes stimulation test revealed that

lymphocytes were stimulated by Shosaiko-to and its components, Saiko* and

Ogon**.[* Radix Bupleuri (chaihu) ** Radix Scutellatiae (huangqin)] A chest

roentgenogram just before ingesting Hangeshashin-to revealed the

interstitial change of the lung. Taken all together, this patient suffered

from drug-induced hepatitis and pneumonitis as a result of ingesting

Hangeshashin-to and Shosaiko-to.

Nihon Toyo Igaku Zasshi (Japanese Journal of Oriental Medicine), 50 (1),

57-65, 1999