Guest guest Posted September 2, 2000 Report Share Posted September 2, 2000 http://www.infotrieve.com/healthworld/std_format.cgi?med93-95+218775+(schisandra\ )+AND+(liver) -- Chinese Herbal Medicine Title Effect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in rats. Author Ip SP; Mak DH; Li PC; Poon MK; Ko KM Address Department of Biochemistry, Hong Kong University of Science Technology, Hong Kong. Source Pharmacol Toxicol, 78(6):413-6 1996 Jun Abstract Treatment of rats with a lignan-enriched extract of the fruit of Schisandra chinensis could enhance hepatic antioxidant/detoxification system, as indicated by increases in hepatic reduced glutathione (GSH) level as well as hepatic glutathione reductase and glutathione S-transferase activities. The hepatoprotective action was evident after aflatoxin beta 1 or cadmium chloride (Cd) challenge. Schisandra chinensis pretreatment protected against aflatoxin B1-or Cd-induced hepatocellular damage in rats. However, pretreating rats with alpha-tocopherol acetate (vitamin E) did not protect against hepatic damage induced by both toxins. Results from the present as well as our previous studies demonstrate that the hepatoprotection afforded by Schisandra chinensis pretreatment is not hepatotoxin specific. Schisandra chinensis seems to be more effective than vitamin E in protecting against aflatoxin B1 and Cd toxicity. The mechanism of hepatoprotection afforded by Schisandra chinensis pretreatment may involve facilitation of both antioxidant and detoxification processes in the liver. Language Eng Unique Identifier 96426940 MESH Headings Aflatoxin B1 *AI/TO AFLATOXIN B01 ; Animal ; Anticarcinogenic Agents *PD ; Antioxidants PD ; Cadmium Chloride *AI/TO ; Carcinogens *TO ; Cytosol DE/ME ; Female ; Glutathione ME ; Hepatitis, Toxic ME/*PC ; Male ; Plant Extracts PD ; Plants, Medicinal *CH ; Rats ; Rats, Sprague-Dawley ; Support, Non-U.S. Gov't ; Vitamin E PD Publication Type JOURNAL ARTICLE ISSN 0901-9928 Country of Publication DENMARK Quote Link to comment Share on other sites More sharing options...
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