Guest guest Posted September 2, 2000 Report Share Posted September 2, 2000 http://www.infotrieve.com/healthworld/std_format.cgi?med85-89+1632698+(schisandr\ a)+AND+(liver) -- Chinese Herbal Medicine Title Inhibitory effect of TJN-101 ((+)-(6S,7S,R-biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy -6,7-dimethyl-10,11- methylenedioxy-6-dibenzo[a,c]cyclooctenol) on immunologically induced liver injuries. Author Ohkura Y; Mizoguchi Y; Sakagami Y; Kobayashi K; Yamamoto S; Morisawa S; Takeda S; Aburada M Address Third Department of Internal Medicine, Osaka City University Medical School, Japan. Source Jpn J Pharmacol, 44(2):179-85 1987 Jun Abstract TJN-101, which is a lignan component isolated from schisandra fruits, inhibits hepatotoxic chemicals-induced liver injuries. In this study, effects of TJN-101 on immunologically induced liver injuries were investigated in vivo and in vitro. When a small dose of lipopolysaccharide was injected into mice previously injected with heat-killed Propionibacterium acnes, most of the animals died with acute hepatic failure which was produced by cytotoxic factors from activated adherent cells, and liver cells were injured by antibody-dependent cell-mediated cytotoxic (ADCC) reaction or activated macrophages in vitro. TJN-101 reduced the mortality of the mice with acute hepatic failure dose-dependently. Histologically, necrosis was suppressed by the treatment of TJN-101, but infiltration of non-specific inflammatory cells was not. TJN-101 inhibited the isolated liver cell injuries induced by ADCC reaction or activated macrophages in vitro. These results suggest that TJN-101 can be markedly protective against immunological liver injuries. Language Eng Unique Identifier 88011860 MESH Headings Alanine Transaminase BL ; Animal ; Antibody-Dependent Cell Cytotoxicity *DE ; Aspartate Transaminase BL ; Guinea Pigs ; Lipopolysaccharides AI ; Liver Diseases *DT/IM/PA ; Macrophage Activation *DE ; Male ; Mice ; Mice, Inbred BALB C ; Polycyclic Hydrocarbons *PD ; Proteins ME Publication Type JOURNAL ARTICLE ISSN 0021-5198 Country of Publication JAPAN Quote Link to comment Share on other sites More sharing options...
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