Guest guest Posted September 2, 2000 Report Share Posted September 2, 2000 http://www.infotrieve.com/healthworld/std_format.cgi?med90-92+957116+(schisandra\ )+AND+(liver) -- Chinese Herbal Medicine Title Anti-oxidant activity of dibenzocyclooctene lignans isolated from Schisandraceae. Author Lu H; Liu GT Address Department of Pharmacology, Chinese Academy of Medical Sciences, Beijing. Source Planta Med, 58(4):311-3 1992 Aug Abstract The anti-oxidant activity of nine dibenzocyclooctene lignans isolated from Schisandra chinensis, S. rubriflora, and Kadsura longipedunculata, respectively, was studied. Seven of the 9 lignans (1 mM) inhibited iron/cysteine-induced lipid peroxidation (malondialdehyde, MDA, formation) of rat liver microsomes as well as superoxide anion production in the xanthine/xanthine oxidase system. The actions of the 7 lignans were much more potent than vitamin E at the same concentration of 1 mM. Among the lignans, schisanhenol was the most active one. This compound also prevented the decrease of membrane fluidity of liver microsomes induced by iron/cysteine. The results indicated that seven of the lignans such as schisanhenol have anti-oxidant activities. Language Eng Unique Identifier 93066767 MESH Headings Animal ; Antioxidants *PD ; Drugs, Chinese Herbal *PD ; Human ; Lignin *PD ; Lipid Peroxidation ; Male ; Microsomes, Liver DE ; Polycyclic Hydrocarbons CH/PD ; Rats ; Rats, Wistar Publication Type JOURNAL ARTICLE ISSN 0032-0943 Country of Publication GERMANY Quote Link to comment Share on other sites More sharing options...
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