vanilla drug tests?

[Guest guest]

If this is what is sounds like, then perhaps vanilla could set off the

test

 

 

http://www.infotrieve.com/healthworld/std_format.cgi?med96-97+317060+(anandamide\

)

 

--

 

Chinese Herbal Medicine

 

 

 

 

 

Title

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide.

Author

Zygmunt PM; Petersson J; Andersson DA; Chuang H; Sørg°ard M; Di Marzo V; Julius D; H¨ogest¨att ED

Address

Department of Clinical Pharmacology, Institute of Laboratory Medicine, University of Lund, Sweden.

Source

Nature, 400(6743):452-7 1999 Jul 29

 

Abstract

The endogenous cannabinoid receptor agonist anandamide is a powerful vasodilator of isolated vascular preparations, but its mechanism of action is unclear. Here we show that the vasodilator response to anandamide in isolated arteries is capsaicin-sensitive and accompanied by release of calcitonin-gene-related peptide (CGRP). The selective CGRP-receptor antagonist 8-37 CGRP, but not the cannabinoid CB1 receptor blocker SR141716A, inhibited the vasodilator effect of anandamide. Other endogenous (2-arachidonylglycerol, palmitylethanolamide) and synthetic (HU 210, WIN 55,212-2, CP 55,940) CB1 and CB2 receptor agonists could not mimic the action of anandamide. The selective 'vanilloid receptor' antagonist capsazepine inhibited anandamide-induced vasodilation and release of CGRP. In patch-clamp experiments on cells expressing the cloned vanilloid receptor (VR1), anandamide induced a capsazepine-sensitive current in whole cells and isolated membrane patches. Our results indicate that anandamide induces vasodilation by activating vanilloid receptors on perivascular sensory nerves and causing release of CGRP. The vanilloid receptor may thus be another molecular target for endogenous anandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.

Language

Eng

Unique Identifier

99366986

 

 

 

 

MESH Headings

Animal ; Arachidonic Acids AI/ME/*PD ; Basilar Artery DE/IR ; Calcitonin Gene-Related Peptide ME/PD ; Calcium Channels ME ; Capsaicin AA/PD ; Cell Line ; Female ; Guinea Pigs ; Hepatic Artery DE/IR ; In Vitro ; Neurons, Afferent DE/*ME ; Peptide Fragments PD ; Rats ; Rats, Wistar ; Receptors, Calcitonin Gene-Related Peptide AI ; Receptors, Drug AG/AI/GE/*ME ; Recombinant Proteins ME ; Support, Non-U.S. Gov't ; Support, U.S. Gov't, P.H.S. ; Vasodilator Agents AI/ME/*PD ; Xenopus

 

 

 

 

Publication Type

JOURNAL ARTICLE

ISSN

0028-0836

Country of Publication

ENGLAND