Guest guest Posted January 25, 2002 Report Share Posted January 25, 2002 Wow, What a great project! Interactions with the most commonly prescribed meds such as cardiac, diabetes, birth control pills/ hormone replacement, antibiotics, etc. would be great. I wonder if there is a site that tells what the most commonly prescribed meds are. Which type of interactions would you be interested in? (pharmacokinetics, pharmacodynamics, toxicology, profile of effect) >>>>>I think knowing which enzyme systems are effected is useful. Which herbs are protein bound and than see what happens to blood levels when taken with protein bound drugs. Any laboratory suggestion of toxicity is useful. That sounds so cool, Alon. I also think it is important to find which are more steroid in function. I often get people asking about herbs acting like MAO inhibitors or Calcium channel blockers. This kind of classification would helpful. (I know it's not TCM but this is what people want to know.) Colleen Message: 3 Wed, 23 Jan 2002 17:33:06 +0100 " Patrick Rudolph " <patim.rudolph herb-drug-interactions Dear all, it looks as if I'd have the possibility to investigate herb-drug interactions in the context of a dissertation in a pharmacological institute. A few studies have been made about this. They mostly looked at one single herb and one specific western drug, comparing parameters like the plasma concentration of the drug in relation to time, when applied simultaneously with the herb. The questions are mostly about pharmacokinetics (resorption, distribution, metabolism, elimination). One problem I see with this approach is that we actually never prescribe one single herb. The idea to check Bai Shao with Valproat or Phenytoin, because Bai Shao might be used in the treatment of epilepsy is a start but clinically pretty irrelevant as we don't know what happens when it is inside a formula, with all the interactions happening between the herbs already. I will have to sort this out with the professor which I'll meet in 2 weeks. For the time being I'd like to collect some possible candidates for investigation. So my questions to you are: 1. Of which substances would you like to know interactions, because you think they are of clinical relevance (single herbs or formulas or diseases or syndromes in combination with drugs, specific ones or groups used for certain diseases)? 2. Which type of interactions would you be interested in? (pharmacokinetics, pharmacodynamics, toxicology, profile of effect) Thanks for proposals and comments Patrick ______________________ The questions are mostly about pharmacokinetics >>>>>>The problem with a formula and pharmacokinetics is that you would not know which markers to look at. But as far as interaction you should still be able to. Which type of interactions would you be interested in? (pharmacokinetics, pharmacodynamics, toxicology, profile of effect) >>>>>I think knowing which enzyme systems are effected is useful. Which herbs are protein bound and than see what happens to blood levels when taken with protein bound drugs. Any laboratory suggestion of toxicity is useful. But I think the bottom line is to actually combine herbs, formulas and drugs and see what happens. Too much of the info we have now is theoretical interactions based on known pharmacological mechanisms from drug drug interactions Alon Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 25, 2002 Report Share Posted January 25, 2002 Patrick, Information on herbs potentiating the effects of the drugs would be useful as well. Thank you, Colleen Thursday, January 24, 2002 4:23 AM Digest Number 870 Message: 3 Wed, 23 Jan 2002 17:33:06 +0100 " Patrick Rudolph " <patim.rudolph herb-drug-interactions Dear all, it looks as if I'd have the possibility to investigate herb-drug interactions in the context of a dissertation in a pharmacological institute. A few studies have been made about this. They mostly looked at one single herb and one specific western drug, comparing parameters like the plasma concentration of the drug in relation to time, when applied simultaneously with the herb. The questions are mostly about pharmacokinetics (resorption, distribution, metabolism, elimination). One problem I see with this approach is that we actually never prescribe one single herb. The idea to check Bai Shao with Valproat or Phenytoin, because Bai Shao might be used in the treatment of epilepsy is a start but clinically pretty irrelevant as we don't know what happens when it is inside a formula, with all the interactions happening between the herbs already. I will have to sort this out with the professor which I'll meet in 2 weeks. For the time being I'd like to collect some possible candidates for investigation. So my questions to you are: 1. Of which substances would you like to know interactions, because you think they are of clinical relevance (single herbs or formulas or diseases or syndromes in combination with drugs, specific ones or groups used for certain diseases)? 2. Which type of interactions would you be interested in? (pharmacokinetics, pharmacodynamics, toxicology, profile of effect) Thanks for proposals and comments Patrick Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 25, 2002 Report Share Posted January 25, 2002 acting like MAO inhibitors >>>>There is some animal information on this, although i do not think it is applicable to humans Alon - Colleen Morris Friday, January 25, 2002 12:14 PM RE: Digest Number 870 Wow, What a great project! Interactions with the most commonly prescribedmeds such as cardiac, diabetes, birth control pills/ hormonereplacement, antibiotics, etc. would be great. I wonder if there is asite that tells what the most commonly prescribed meds are.Which type of interactions would you be interested in?(pharmacokinetics,pharmacodynamics, toxicology, profile of effect)>>>>>I think knowing which enzyme systems are effected is useful. Whichherbs are protein bound and than see what happens to blood levels whentaken with protein bound drugs. Any laboratory suggestion of toxicity isuseful.That sounds so cool, Alon. I also think it is important to find whichare more steroid in function.I often get people asking about herbs acting like MAO inhibitors orCalcium channel blockers. This kind of classification would helpful. (Iknow it's not TCM but this is what people want to know.)ColleenMessage: 3 Wed, 23 Jan 2002 17:33:06 +0100 "Patrick Rudolph" <patim.rudolphherb-drug-interactionsDear all,it looks as if I'd have the possibility to investigate herb-druginteractions in the context of a dissertation in a pharmacologicalinstitute. A few studies have been made about this. They mostly lookedatone single herb and one specific western drug, comparing parameters liketheplasma concentration of the drug in relation to time, when appliedsimultaneously with the herb. The questions are mostly aboutpharmacokinetics (resorption, distribution, metabolism, elimination).One problem I see with this approach is that we actually never prescribeonesingle herb. The idea to check Bai Shao with Valproat or Phenytoin,becauseBai Shao might be used in the treatment of epilepsy is a start butclinically pretty irrelevant as we don't know what happens when it isinsidea formula, with all the interactions happening between the herbsalready.I will have to sort this out with the professor which I'll meet in 2weeks.For the time being I'd like to collect some possible candidates forinvestigation.So my questions to you are:1. Of which substances would you like to know interactions, because youthink they are of clinical relevance (single herbs or formulas ordiseasesor syndromes in combination with drugs, specific ones or groups used forcertain diseases)?2. Which type of interactions would you be interested in?(pharmacokinetics,pharmacodynamics, toxicology, profile of effect)Thanks for proposals and commentsPatrick______________________The questions are mostly aboutpharmacokinetics>>>>>>The problem with a formula and pharmacokinetics is that you wouldnot know which markers to look at. But as far as interaction you shouldstill be able to. Which type of interactions would you be interested in?(pharmacokinetics,pharmacodynamics, toxicology, profile of effect)>>>>>I think knowing which enzyme systems are effected is useful. Whichherbs are protein bound and than see what happens to blood levels whentaken with protein bound drugs. Any laboratory suggestion of toxicity isuseful. But I think the bottom line is to actually combine herbs, formulas anddrugs and see what happens. Too much of the info we have now istheoretical interactions based on known pharmacological mechanisms fromdrug drug interactionsAlonChinese Herbal Medicine, a voluntary organization of licensed healthcare practitioners, matriculated students and postgraduate academics specializing in Chinese Herbal Medicine, provides a variety of professional services, including board approved online continuing education. Quote Link to comment Share on other sites More sharing options...
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