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Indian J Physiol Pharmacol 2001 Oct;45(4):435-41 Related Articles, Books,

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In vivo hepatoprotective activity of active fraction from ethanolic

extract of Eclipta alba leaves.

Singh B, Saxena AK, Chandan BK, Agarwal SG, Anand KK.

Division of Pharmacology, Regional Research Laboratory, Jammu Tawi-180 001.

The alcoholic extract of fresh leaves of the plant Eclipta alba (Ea),

previously reported for is hepatoprotective activity was fractionated into

three parts to chemically identify the most potent bioactive fraction. The

hepatoprotective potential of the fraction prepared from extract was

studied in vivo in rats and mice against carbon tetrachloride induced

hepatotoxicity. The hepatoprotective activity was determined on the basis

of their effects on parameters like hexobarbitone sleep time, zoxazolamine

paralysis time, bromosulphaline clearance, serum transaminases and serum

bilirubin. Fraction EaII (10-80 mg/kg, p.o.) containing coumestan

wedelolactone and desmethylwedelolactone as major components with apigenin,

luteolin, 4-hydroxybenzoic acid and protocateuic acid as minor

constituents exhibited maximum hepatoprotective activity and is the active

fraction for hepatoprotective activity of Eclipta alba leave. The acute

toxicity studies have shown that like Ea, Fraction EaII also high safety

margin.

PMID: 11883149 [PubMed - in process]

 

Zhongguo Zhong Yao Za Zhi 1998 Nov;23(11):680-2, 703 Related Articles, Books,

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[Preliminary studies on chemical constituents and pharmacological action

of Eclipta prostrata L.]

[Article in Chinese]

Han Y, Xia C, Cheng X, Xiang R, Liu H, Yan Q, Xu D.

Jiangsu Provincial Institute of Materia Medica, Nanjing 210009.

OBJECTIVE: To study the pharmacologically active components of Eclipta

prostrata. METHOD: The components were extracted by alcohol and isolated

by silica gel column and subjected to pharmacological screening. RESULT:

Four compounds were isolated from E. prostrata, of which two were

identified as stigmasterol and alpha-terthienyl. CONCLUSION:

alpha-Terthienyl was isolated from the plant for the first time. The EtOAc

part of alcoholic extraction exhibits significant hepatoprotective

activity against carbon terachloride-induced liver injury in rats.

PMID: 11599347 [PubMed - indexed for MEDLINE]

 

J Ethnopharmacol 1993 Dec;40(3):155-61 Related Articles, Books, LinkOut

 

Hepatoprotective effects of Eclipta alba on subcellular levels in rats.

Saxena AK, Singh B, Anand KK.

Department of Pharmacology, Regional Research Laboratory, Jammu-Tawi,

India.

The hepatoprotective effect of the ethanol/water (1:1) extract of Eclipta

alba (Ea) has been studied at subcellular levels in rats against

CCl4-induced hepatotoxicity. Ea significantly counteracted CCl4-induced

inhibition of the hepatic microsomal drug metabolising enzyme amidopyrine

N-demethylase and membrane bound glucose 6-phosphatase, but failed to

reverse the very high degree of inhibition of another drug metabolising

enzyme aniline hydroxylase. The loss of hepatic lysosomal acid phosphatase

and alkaline phosphatase by CCl4 was significantly restored by Ea. Its

effect on mitochondrial succinate dehydrogenase and adenosine

5'-triphosphatase was not significant. The study shows that

hepatoprotective activity of Ea is by regulating the levels of hepatic

microsomal drug metabolising enzymes.

PMID: 8145570 [PubMed - indexed for MEDLINE]

 

 

 

 

 

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