Guest guest Posted January 16, 2003 Report Share Posted January 16, 2003 Bob et al. The difficulty with the concentration ratios vis-a-vis granular extracts is that they vary not only from company to company but also from medicinal to medicinal. Furthermore, I even suspect that they change from batch to batch by at least a little bit. Some people on this list have said that, for example, KPC make 5:1 extracts. That is only an average. Some are more, others are much less. How do you make a 5:1 extract of Mang Xiao, Shi Jue Ming, Mu Li, etc? Plus, the concentration ratio is generally calculated in the following way: 12 grams of raw herbs are used to produce 2 grams of extract. This then makes a 6:1 concentration. But then comes the real bummer...the starch (wheat starch, corn starch, etc.) is added after the calculation has been made. And the amount of starch added is not small. Generally, it is somewhere around 30-40%. Calculate that into the 6:1 and you end up with more like a 3.5:1. So the concentration ratio of 5:1 is really not a very correct number when it comes to KPC and other Taiwanese production facilities (such as Shen Fong which produces for Evergreen, etc.). In reality, the concentration seems to be much lower. The other problem with doing such a comparative analysis is that not all companies are honest (and they often have good reasons for it...;-)). Checking the amount of starch in a product is exceedingly difficult. Qualitative analysis, such as fingerprinting for identity and certain active ingredients is one thing. Determining the amount of substance (quantitative analysis) is more difficult and especially much more expensive. As the person in charge of quality for Chinese medicinals in a Swiss Chinese medical company, I would like to add my two cents about the impurties issue. Since beginning my job, I have collected quite some experiences with pesticides, heavy metals, aflatoxins, aristolochic acid (AA) etc. Unfortunately, I have to say that especially heavy metals, aflatoxins and aristolochic acid are still a big problem in the herbal products coming from Taiwan. Just because one has a positive TLC picture for, let's say Stephania, Mu Tong, this is by no means proof for negativity as far as AA is concerned. I have seen these kind of tests too many times...if a quarter of the batch comes from an aristolochia plant (and that happens), then the end product contains AA, no matter how the TLC looks. Plus, it is extremely difficult to find, for example, Semen Biotae Orientalis without aflatoxins. As far as crude herbs are concerned, I have yet to see a negative batch. With granules, there are clean batches once in a while. Plus I suggest to interested people to test yan hu suo for aflatoxins. I would almost guarantee a high B1 count (but that is an entirely different story and needs more analysis.) My point is that before beginning to look for ratios, I would check for impurities. The problem in the US is that there are no laws requiring testing (at least not that I am aware of). Sometimes we order products from the US and test them prior to selling them. Unfortunately, I have found all kinds of toxins, most strikingly aflatoxins, cadmium (our limit is 0.5 here, I believe it is higher in the US. However, Cd levels of 0.9 seem a bit high to me), and Aristolochic acid. So even though I support the idea of such a comparative statistic, I am afraid that it would not be a good one unless someone wants to put in a couple of 100,000 US Dollars. Unless the products are tested and verified, this comparative analysis would be as good as useless. Simon Becker Quote Link to comment Share on other sites More sharing options...
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