SARS - NEJM Full Text

May 15, 2003

Dear Jim, Rey, Phil and all who read NEJM articles,

Here's a list of URLs that will lead you to the "full text" of the entire collection of New England Journal of Medicine's articles on SARS. Nice to have the entire collection of full text URLs on one e-mailing. This collection, plus a set of steak knives that never need sharping ....

All the Best, Emmanuel Segmen

Perspective: Managing SARS amidst Uncertainty R.P. Wenzel and M.B. Edmond<http://content.nejm.org/cgi/content/full/348/20/1947?query=TOC>[Free full text of this article]Perspective: SARS-Associated Coronavirus K.V. Holmes<http://content.nejm.org/cgi/content/full/348/20/1948?query=TOC>[Free full text of this article]Perspective: SARS and Carlo Urbani B. Reilley and Others<http://content.nejm.org/cgi/content/full/348/20/1951?query=TOC>[Free full text of this article]=================ORIGINAL ARTICLES=================A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome T.G. Ksiazek and Others<http://content.nejm.org/cgi/content/full/348/20/1953?query=TOC>[Free full text of this article]Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory Syndrome C. Drosten and Others<http://content.nejm.org/cgi/content/full/348/20/1967?query=TOC>[Free full text of this article]A Cluster of Cases of Severe Acute Respiratory Syndrome in Hong Kong K.W. Tsang and Others<http://content.nejm.org/cgi/content/full/348/20/1977?query=TOC>[Free full text of this article]A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong N. Lee and Others<http://content.nejm.org/cgi/content/full/348/20/1986?query=TOC>[Free full text of this article]Identification of Severe Acute Respiratory Syndrome in Canada S.M. Poutanen and Others<http://content.nejm.org/cgi/content/full/348/20/1995?query=TOC>[Free full text of this article]===========================IMAGES IN CLINICAL MEDICINE===========================Radiologic Manifestations of Severe Acute Respiratory Syndrome S. Nicolaou and Others<http://content.nejm.org/cgi/content/full/348/20/2006?query=TOC>[Free full text of this article]

May 17, 2003

Here is a case history of actual muscle damage in a patient taking red yeast rice

Alon

Rhabdomyolysis due to red yeast rice (Monascus purpureus) in a renal transplant recipient.

Transplantation 2002 Oct 27;74(8):1200-1 (ISSN: 0041-1337)

Prasad GV; Wong T; Meliton G; Bhaloo S Division of Nephrology, Department of Medicine, St. Michael's Hospital, University of Toronto, 61 Queen Street East, 9th Floor, Toronto, Ontario M5C 2T2 Canada. prasadr.

Rhabdomyolysis is a known complication of hepatic 3-methylglutaryl coenzyme A reductase (HMG-CoA) inhibitor (statin) therapy for posttransplant hyperlipidemia, and thus monitoring for this effect is indicated. We report a case of an herbal preparation-induced rhabdomyolysis in a stable renal-transplant recipient, attributed to the presence of red yeast rice (Monascus purpureus) within the mixture. The condition resolved when consumption of the product ceased. Rice fermented with red yeast contains several types of mevinic acids, including monacolin K, which is identical to lovastatin. We postulate that the interaction of cyclosporine and these compounds through the cytochrome P450 system resulted in the adverse effect seen in this patient. Transplant recipients must be cautioned against using herbal preparations to lower their lipid levels to prevent such complications from occurring.