Fwd: Cushing's disease and kidney yin deficiency

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> " danceswithmeena " <jackie

> Fri Jul 04, 2003 01:51:37 PM US/Pacific

>

> Cushing's disease and kidney yin deficiency

>

> I wonder if anyone can help me untangle the following.

>

> In the article:

>

> " Integrating the Traditional Chinese

> Understanding of the Kidneys into Western Herbalism "

>

> Michael Tierra says

>

> " Also like cortisone, the regular and excess use of licorice will

> produce

> the edemic, moon face appearance of Cushing's syndrome, a condition

> which

> can be described as `deficient kidney yang. "

>

> He definately strongly equates cortisol with kidney yin, and the

> following

> medline paper appears to agree with this:

>

> 1: Zhong Yao Cai. 2000 Mar;23(3):164-6. Related Articles,Links

>

> [study on erzhi pill effects on neuro-endocrinologic-immuno network of

> animal of deficiency of yin]

> [Article in Chinese]

> Cao H, Liang S, Rong X, Wu Q.

> Guangzhou University of Traditional , Guangzhou

> 510405.

>

> ....The changes of the animals of deficiency of Yin and the effects

> of the

> Erzhi

> Pill were investigated. RESULT: It showed that rats of deficiency of

> Yin,

> their hemotic, cortisol, insulin, testosterone, beta-endorphin,

> weight of

> adrenal and thymus decreased, cholesterol increased and mouse of

> deficiency

> of Yin, their lymphocyte proliferation and activity of NKC dcreased,

> which

> might be modulated with Erzhi Pill.

> ...............

>

> Others authors disagree however, and believe just the opposite, and

> some

> papers seem to support the opposite view:

>

> [Effect of regulation of kidney-yin and kidney-yang on

> hypothalamus-pituitary-adrenal-thymus axis in monosodium L-glutamate

> rats]

> [Article in Chinese]

> Cai D, Chen X, Liu Y.

> Institute of Integrated Traditional and Western Medicine, Shanghai

> Medical

> University, Shanghai (200040).

>

> OBJECTIVE: To study the interrelationship between

> hypothalamus-pituitary-adrenal-thymus (HPAT) axis and Kidney-Yang and

> Kidney-Yin in arcuate nucleus destroyed rats. METHODS: Monosodium

> glutamate(MSG) 4 mg/g body weight was given subcutaneously to

> neonatal rats

> at 2, 4,6, 8 and 10th day after born to destroy the ARC, and Zuogui

> pill or

> Yougui pill (5 g/kg daily) was given respectively by gastrogavage

> when the

> model

> rats entered adulthood. RESULTS: Immunohistochemical staining showed

> that in

> the model group the number of corticotropin-releasing hormone (CRH)

> positive

> neurons in hypothalamic paraventricular nucleus and anterior pituitary

> adrenotrophin (ACTH) positive secretory cells, which stained deeply,

> were

> more than those in the control group, the adrenal fasciculate zone

> disturbed

> with increased cells and obviously dilated sinusoid. The thymus

> atrophied

> with lymphocyte proliferation apparently lower, blood corticosterone,

> ACTH

> content and hypothalamic CRF level higher in the model than those in

> the

> control. Zuogui pill could improve above-mentioned pathophysiologic

> changes

> effectively but Yougui pill could not. CONCLUSION: Process of

> pathophysiology of HPA axis hyperfunction accompanied cell-mediated

> immunodeficiency may belong to the category of Kidney-Yin Deficiency

> Syndrome.

> ........

>

> I purchased Blue Poppy Press Recent Research Report # 126 hoping to

> resolve

> the issue, and the true disease (as opposed to the pseudo-condition

> brought

> about by corticosteroid use) was described as Liver heat, depression,

> and

> dampness arising from Kidney yin deficiency (as I had been led to

> believe)and treated with a Rehmannia formula (as I would have

> expected).

>

> However the action of Rehmannia on on the adrenals seems similarly

> confused - several authors seem to feel it has been shown to raise

> cortisol

> levels, which of course would be the last thing one would want in a

> hyperadrenocortical condition like Cushing's disease, or indeed

> diabetes (as

> cortisol is antagonistic to insulin). The only papers on the subject

> I can

> find listed on pubmed have no abstracts available.

>

> Can anyone shed further light on this question please?

>

> Many thanks

>

> Jackie Taylor

>

>

>

>

>

 

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