MM and jiang huang

[Guest guest]

while not about myleoma per se, this specific abstract suggest inhibition

of marrow cell proliferation in vitro by turmeric

 

BTW, this is a blood moving herb in TCM

 

J Cancer Res Clin Oncol. 1992;118(6):447-52. Related Articles, Links

 

Protective role of aqueous turmeric extract against mutagenicity of

direct-acting carcinogens as well as benzo [alpha] pyrene-induced

genotoxicity and carcinogenicity.

Azuine MA, Kayal JJ, Bhide SV.

Carcinogenesis Division, Tata Memorial Centre, Parel, Bombay, India.

Turmeric (Curcuma longa Linn.) has been shown to inhibit chemical

carcinogenesis. In this study, we compared the chemopreventive efficacy of

an aqueous turmeric extract (AqTE) and its constituents, curcumin-free

aqueous turmeric extract (CFAqTE) and curcumin, using the Salmonella

typhimurium mutagenicity assay and the bone marrow micronucleus test in

female Swiss mice. AqTE exhibited antimutagenic activity against

direct-acting mutagens, 4-nitro-O-phenylenediamine and

1-methyl-3-nitro-1-nitrosoguanidine, in strains TA 98 and TA 100

respectively. Both AqTE and CFAqTE inhibited the mutagenicity of benzo

[alpha]pyrene in the two strains in the presence of Aroclor-1254-induced

rat liver homogenate. The inhibition in both studies was dose-dependent.

Administration of AqTE, CFAqTE and curcumin at a dose of 3 mg/animal 18 h

prior to i.p. benzo [alpha]pyrene injection (250 mg/kg) significantly

inhibited bone marrow micronuclei formation in female Swiss mice by 43%,

76%, and 65% respectively. Furthermore, the incidence and multiplicity of

forestomach tumours induced by benzo [alpha]pyrene (1 mg/animal, twice

weekly, p.o. for 4 weeks) in female Swiss mice were significantly

inhibited by AqTE, CFAqTE and curcumin given 2 weeks before, during and

after the carcinogen treatment. These data indicate that the protection

against genomic damage by turmeric extract and its components tested could

be necessary for some aspects of its cancer chemoprevention.

 

 

 

Chinese Herbs

 

 

" Great spirits have always found violent opposition from mediocre

minds " -- Albert Einstein