RE: Digest Number 1598

[Guest guest]

I have used these herbs for moms with infections, during pregnancy, but

(for the reasons you stated) I avoid berberine contain herbs.

 

Thomas,

 

Here is an interesting abstract on the in vitro use of Huang Qi on

infected amnion cells. Have you or anyone else on the list tried using

Huang Qi for infection during pregnancy?

 

 

Biol Pharm Bull 2002 Jan;25(1):77-80

 

 

Effect of Astragali radix extract on lipopolysaccharide-induced

inflammation in human amnion.

 

Shon YH, Kim JH, Nam KS.

 

Department of Pharmacology, College of Medicine and Intractable Disease

Research Center, Dongguk University, Sukjang-Dong, Kyongju, Korea.

 

The effects of Astragali radix extract on interleukin (IL)-6 and tumor

necrosis factor (TNF)-alpha productions, prostaglandin E2 (PGE2)

biosynthesis, and leukotriene C4 (LTC4) production from

lipopolysaccharide (LPS)-stimulated human amnion cells were

investigated. Amnion cells produced detectable amounts of both IL-6 and

TNF-alpha under LPS-stimulated conditions. Astragalus extract inhibited

the production of IL-6. However, TNF-alpha production was not inhibited

by the extract on L929 cytotoxicity assay. Treatment of amnion cells

with LPS for up to 24 h resulted in an increase in PGE2 release in a

concentration- and time-dependent manner. The extract (150 mg/ml)

significantly inhibited the output of PGE2 by amnion cells (p<0.01). The

arachidonate lipoxygenase metabolite (LTC4) was increased by LPS

treatment of amnion cells. Astragalus extract (30 mg/ml) inhibited LTC4

production by approximately 65% throughout the culture period. These

results suggest that Astragali radix extract may have a role in

inhibiting bacterial infection-associated preterm labor by suppressing

the productions of IL-6, PGE2, and LTC4 by human amnion cells.

 

PMID: 11824562 [PubMed - indexed for MEDLINE]

 

Thanks for all your info!

 

Colleen