KANGLAITE in Cancer - Yiyiren? Other Ingredients?

[Guest guest]

Hi All, & Hi Steve, Attilio & Marty,

 

About 1 week ago, Steve alerted us to a new anticancer product

being tested in USA and other countries.

 

He wrote: " Kanlight's basic ingredient is Yi Mi Ren. A huge

promotion campaign is running in China and Russia " .

 

I replied:

> I found no hits on Google Advanced OR Advanced for the

> profile: Kanlight AND (Yi-Mi-Ren OR YiMiRen OR Yi-yi-Ren OR

> YiyiRen) . Where did you hear that Coix seed was the main

> ingredient of Kanlight?

 

Marty Eisen (and Attilio forwarded the mail) wrote:

> Phil: Information on the above can be found at

> http://www.annieappleseedproject.org/kanin.html |

> http://www.annieappleseedproject.org/howkanwor.html |

> http://www.annieappleseedproject.org/tradchinmed1.html and by

> searching using " Kanglaite " and " Kanlaite " .

 

Marty & Attilio, many thanks! Many hands make light work!

 

The problem was with the original spelling. The correct spelling [the

one with most hits on Google] is " KANGLAITE " .

 

Following Marty's tips, I found the following on WWW:

 

" KANGLAITE (marketed by Oncoherb) is the " neutral lipid " of the

endosperm of Yiyiren (Job’s tears S), extracted with an organic

solvent, and further refined and washed in several simple steps,

then combined with glycerol and lecithin from soy or egg to make

an emulsion in water that can be injected intravenously into

patients.

 

ACTIONS: Inhibits mitosis of tumour cells during G2/M phase of

the cell cycle; Induces death of tumour cells; Increases expression

of genes – FAS, Apo-1 – that inhibits the growth of cancer cells

and represses expression of the gene Bel-2 that promotes the

growth of cancer cells; Inhibits formation of new blood vessels that

promote tumour growth; Counteracts weight loss due to cancer;

Reverses multi-resistance of tumour cells to anti-tumour drugs;

significantly improves the efficacy of radiotherapy and

chemotherapy in late-stage, non-lobular lung cancer patients. It is

far less toxic than existing chemotherapeutic agents and is

effective in patients for whom existing treatments did not show any

improvements.

 

BACKGROUND: The anti-tumour action of lipids extracted from the

endosperm of Job’s tears was known much earlier: it was reported

for the first time by Japanese scientists Tyunosin Ukita and Ako

Tanumura in 1961, and again in the 1980s by Chinese scientist, Si

Pei-hai. But the earlier extracts were not economical enough for

the market, and the formulations were not pure enough for clinical

use.

 

The " neutral lipid " turns out to be a rather unremarkable mixture of

triglycerides (over 90%) with smaller amounts of diglycerides

(about 1.5%), monoglycerides (about 6 %) and alkylacylacetin

(about 1%). These lipids have a rather ordinary profile of saturated

and unsaturated long-chain fatty acids (16 and 18 carbons).

Despite the wide spectrum of benefits claimed for the " neutral

lipid " , based both on in vitro studies in cell cultures and in vivo

studies in mice, and later in human subjects, it is unclear whether

different components of the mixture are responsible for specific

effects, or it is the mixture per se that has all those effects. There

is a strong underlying assumption, nevertheless, that the different

effects are due to different components in the grain, and indeed, a

number of pharmacologically and physiologically active substances

have been isolated from different parts of the Coix plant that show

specific anti-inflammatory, anti-tumour, anti-microbial,

hypoglycaemic, and ovulatory effects.

 

A team of researchers at the National Taiwan University has

recently identified 6 phenolic compounds in the hull (shell) of Job’s

tears that have strong anti-oxidant activities. The researchers

showed that different parts of the grain vary in their content of anti-

oxidants, with the greatest amounts in the hull, followed by the

testa (seed membrane) and the bran, and the smallest amounts in

the polished grain. And the six phenolic compounds also had

different degrees of anti-oxidant effects. Antioxidants inhibit the

oxidation of lipids in cell membranes, leading to impairment of cell

function. Antioxidants neutralise reactive oxygen species (ROS)

and oxygen free radicals. Excess ROS is implicated in diseases

such as inflammation, aging, atherosclerosis (hardening of the

arteries), cancer, rheumatoid arthritis, and liver toxicity. (See

Organic agriculture helps fight cancer, ISIS report.)

 

CRITICISM: Despite these clear successes, however, there are

critics who claim, justifiably, that the present penchant for

extracting and purifying herbal medicine is anathema to the very

tradition of Chinese medicine. Chinese herbal medicines frequently

involve not just the single unprocessed herb, but especially

mixtures of many herbs in different proportions, according to the

needs of individual patients (see Globalising Chinese medicine, this

series). The aim is to restore the patient to physiological balance

that’s synonymous with the state of health.

 

The experience of conventional Western medicine has amply

demonstrated that knowing the molecular mechanisms of a

compound is no guarantee that it will have the desired benefit for

the organism, for the simple reason that all parts of the organism

are interconnected and intercommunicating. Nevertheless,

knowledge of molecular mechanisms can contribute to

understanding the whole, once we stop seeing the organism as a

collection of separate molecular nuts and bolts. Besides,

identifying the different components in a mixture could contribute to

quality assurance and standardisation, discouraging forgeries and

malpractice in medications that are going to be increasingly

important for global healthcare.

 

SUGGESTION: In view of the numerous health benefits of this

widely distributed staple food, why not incorporate the Coix grain

into everyone’s diet? It serves to bring home the most distinctive

aspect of traditional Chinese medicine: good nutrition is

indistinguishable from health promotion, and food shades

insensibly into medicine that’s widely available and affordable.

 

I believe that the tension between the analytical reductionist and

the synthetic holistic approaches will be resolved in the spirit of the

organic materialism and eclectic pragmatism characteristic of the

Chinese culture through the ages (see Traditional Chinese

medicine & contemporary western science, this series). The more

important tension is between corporations that want to extract

maximum profit from patented medicines and the health needs of

ordinary people as well as the danger of over-harvesting of wild

plant species.

 

The principal competitive advantage of the new drug is its low

toxicity, which is unique among current cancer therapies available.

Emerging therapies (such as retinoids) that promise to be less

toxic than current therapies, are one to two decades away from

being available to patients. The new drug is poised to enter the

market several years ahead of emerging treatments. In addition to

its injection form, Oncoherb is studying its other formulations, such

as capsule or inhalable form " .

 

For Medline abstracts articles linked to Kanglaite, see

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed & cmd=Di

splay & d opt=pubmed_pubmed & from_uid=12572387

 

[Enter the complete address in your Web Browser, with no blank

spaces]

 

Best regards,

Phil

 

>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

 

My notes on Yiyiren are:

 

Pinyin Name: Yiyiren; Yimiren; Yiren; Yimi; Miren; (See:

Chaoyiyiren)

 

Latin Name: Coicis Lacrymaejobi S

 

Common Name: Coix S, Job’s Tears S; Chinese pearl barley

 

Main Hb Class: Aid Water/Drain Damp~Reduce Swelling

 

Main Actions: (1) Build SP; Diuretic; Expel Damp; Drain

Damp~gentle; Expel Water; Rectify Water Metabolism;

Antioedema;

(2) Build SP; Antidiarrhoea; (3) Antifever; Expel Damp Heat;

Antiarthralgic; Free Channel Bi; Ease Spasm; (4) Clear

Heat+Drain

Sepsis; Expel Sepsis; Drain Abscess; Reduce Swelling; (5)

Also:

Tonic~general; Immunostimulant; Antioxidant/Antiageing; Boost

Lymphoblast Transformation; Boost T-Lymphocyte Production;

Anticancer**; Cancer (BL; cervix/uterus; intestine/LI*; LU*; ST);

Hypoglycaemic; Aid LU; Build Yang Qi;

 

Nature: Sweet; Neutral/Bland; Cool

 

Channels: SJM-SP-ST; LU; KI; LI

 

Dose: Powder/Soup (Oral/Topical); As soup: 10-30g; may use 30-

60g alone as Soup; Common food item in China; Japan; liquor from

fermented S is Antirheumatic; Crude Hb: Expel Damp Heat; Hb can be

cooked w polished nonglutinous rice to thick soup/gruel; take w food

as medicated diet; Chaoyiyiren/parched Hb: Antidiarrhoea

 

Indications: Popular food Hb alone/in Soups in arthralgia,

rheumatism; rheumatoid arthritis; muscle spasm; fever; beriberi;

body~heaviness; LU DysFx; LU~abscess, cough, sputum; pus;

chest~oppressive sensation; SJM-SP-ST DysFxs; SI-LI DysFxs;

epigastrium~oppressive sensation; anorexia; SI- LI~Enteritis~Chronic;

diarrhoea; LI~appendicitis/intestine~abscess; KI/BL DysFxs;

prostatitis/BPH; oedema; dysuria, strangury, KI/BL~uroliths;

Leucorrhoea (Topical); Skin~ (Topical in Dermatitis/eczema; Warts);

 

Combinations: (1) Yiyiren w Fangji, Rz Atractylodis, S Pruni, etc in

SP Xu w Damp Stasis w dysuria, strangury, oedema, beriberi/diarrhoea,

etc; Damp Heat w Strangury, KI/BL~uroliths; Damp Febrile Disease w

fever, body~heaviness, chest~oppressive sensation,

epigastrium~oppressive sensation, anorexia; tongue coat smooth/greasy;

(2) Yiyiren w Baizhu, Fuling, Shanyao, etc in SP Xu w Damp w

diarrhoea; Yiyiren w Shanyao, Qianshi, etc. in Damp/Damp Heat w

leucorrhoea; Yiyiren w Zexie; Baizhu in SP Xu w oedema, dysuria;

diarrhoea; (3) Yiyiren w Expel Wind+Expel Damp Hbs in Channel Bi w

muscle spasm; arthralgia in Wind Damp; Yiyiren w Rz Atractylodis,

Rendongteng, Huangbai, etc in Damp Heat w arthralgia; Yiyiren w

Huashi, Zhuye; Tongcao in San Ren Tang (Three Seeds Soup)/other

Antifever/Expel Damp Heat Hbs in Damp Heat~early w EPF in Qi level w

Febrile Disease; (4) Yiyiren w Taoren, Mudanpi, Lugen, etc/Yiyiren w

Taoren, Weijing, Dongguaren in Qian Jin Wei Jing Tang in Damp Heat

Stasis/Qi-Xue Stasis w LU abscess, cough, sputum; pus; Yiyiren w

Taoren, Mudanpi, Daxueteng, Jinyinhua, etc/Yiyiren w Baijiangcao in

Yiyi Fuzi Baijiang San in Damp Heat Stasis/Qi-Xue Stasis w

LI~appendicitis/intestine~abscess

 

Caution: Pregnancy; Use dry-fried Hb to Build SP

 

 

------- End of forwarded message -------

Best regards,

 

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