Osteoblastic proliferative activity of extracts of Qing'e pill and its disassembled formulae

[Guest guest]

Hi All,

 

Have you any experience on the clinical efficacy of " Qing's Pill "

(ingredients: Hetaoren + Buguzhi, Duzhong & Dasuan). Is it

effective to stimulate bone proliferation in fracture, osteoporosis,

etc?

 

See abstract below.

 

Best regards,

Phil

 

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Osteoblastic proliferative activity of extracts of Qing'e Pill and its

disassembled formulae. Xiong, ZL; Guo, XJ; Meng, FH; Li, FM

Pharmaceutical Biology (Netherlands) VOL. 41, NO. 6, 2003, 434-

438. Shenyang Pharmaceut Univ, Sch Pharm, POB 44,103

Wenhua Rd, Shenyang 110016, Peoples R China

fameili Qing'e pill is one of the famous traditional

Chinese compound prescriptions used to treat bone diseases. It

contains four botanical drugs, i.e., the cortex of Eucommia

ulmoides Oliv., the fruit of Psoralea corylifolia L., the seed of

Juglans regia L. and the rhizome of Allium sativum L. In this study,

osteoblastic proliferation activity of extracts from Qing'e pill and its

disassembled formulae was investigated with the osteoblast-like

UMR106 cell line as a model. The extract of Qing'e pill, both

alcohol and aqueous, stimulated cell proliferation in a dose-

responsive manner. The proliferative activity of alcohol extract was

more potent than that of the aqueous one with a maximal growth

stimulation ratio (GSR) of 58.5% versus 38.8%. Eucommia

ulmoides and Psoralea corylifolia produced a maximum proliferative

promotion of 38.7% and 34.0%, respectively, when co-cultured with

UMR106 cells. Neither Juglans regia nor Allium sativum showed a

significant effect on osteoblastic proliferation. When Eucommia

ulmoides and Psoralea corylifolia were combined, the stimulating

action (GSR = 47.2%) became stronger than that of either

individual drug. The enhancement effect was more marked when

Juglans regia or both Juglans regia and Allium sativum were added.

These results demonstrated the synergy of the four botanical drugs

and the rationality of Qing'e pill prescription in a modern scientific

way. This is the first time to study the stimulating osteroblastic

proliferation effect of a traditional Chinese compound prescription

on the basis of disassembled formulae.

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Best regards,

 

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