Guest guest Posted April 29, 2004 Report Share Posted April 29, 2004 Hi All, Below, see some recent abstracts on AP / TENS. Phil >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> AP and acupressure for the management of chemotherapy-induced nausea and vomiting. Collins KB; Thomas DJ. J Am Acad Nurse Pract VOL. 16, 2004, Feb, 76-80. Univ of Connecticut, USA. PURPOSE: To review existing research, the National Institutes of Health (NIH) consensus statement, and federal regulations regarding the use of AP and acupressure in the management of chemotherapy-induced nausea and vomiting in order to give nurse practitioners (NPs) the information they need to provide the best care for patients undergoing chemotherapy treatment for cancer. DATA SOURCES: Selected scientific literature and Internet sources. CONCLUSIONS: Research supports the effectiveness of AP and acupressure for the treatment of chemotherapy-induced nausea and vomiting. Used in conjunction with current antiemetic drugs, AP and acupressure have been shown to be safe and effective for relief of the nausea and vomiting resulting from chemotherapy. IMPLICATIONS FOR PRACTICE: Even with the best antiemetic pharmacological agents, 60% of cancer patients continue to experience nausea and vomiting when undergoing chemotherapy treatments Because the NIH supports the use of AP for nausea and vomiting, the NP is obligated to be knowledgeable about the use of these and other effective complementary treatments in order to provide the best care. AP for chronic headache in primary care: large, pragmatic, randomised trial. Vickers AJ; Rees RW; Zollman CE; McCarney R; Smith CM; Ellis N; Fisher P; Van Haselen R. BMJ, VOL. 328, NO. 7442, 2004, Mar 27, 744. Integrative Medicine Service, Biostatistics Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, NY, NY 10021, USA. vickersa OBJECTIVE: To determine the effects of a policy of " use AP " on headache, health status, days off sick, and use of resources in patients with chronic headache compared with a policy of " avoid AP " DESIGN: Randomised, controlled trial. SETTING: General practices in England and Wales. PARTICIPANTS: 401 patients with chronic headache, predominantly migraine. Interventions Patients were randomly allocated to receive up to 12 AP treatments over three months or to a control intervention offering usual care. MAIN OUTCOME MEASURES: Headache score, SF-36 health status, and use of medication were assessed at baseline, three, and 12 months. Use of resources was assessed every three months. RESULTS : Headache score at 12 months, the primary end point, was lower in the AP group (16.2, SD 13.7, n = 161, 34% reduction from baseline) than in controls (22.3, SD 17.0, n = 140, 16% reduction from baseline). The adjusted difference between means is 4.6 (95% confidence interval 2.2 to 7.0; P = 0.0002). This result is robust to sensitivity analysis incorporating imputation for missing data. Patients in the AP group experienced the equivalent of 22 fewer days of headache per year (8 to 38). SF-36 data favoured AP , although differences reached significance only for physical role functioning, energy, and change in health. Compared with controls, patients randomised to AP used 15% less medication (P = 0.02), made 25% fewer visits to general practitioners (P = 0.10), and took 15% fewer days off sick (P = 0.2). CONCLUSIONS: AP leads to persisting, clinically relevant benefits for primary care patients with chronic headache, particularly migraine. Expansion of NHS AP services should be considered. AP for chronic low back pain in older patients: a randomized, controlled trial Meng CF; Wang D; Ngeow J; Lao L; Paget S et al Rheumatology VOL. 42, NO. 12, 2003, 1508-1517. Hosp Special Surg, Dept Rheumatol, 535 E 70th St, New York, NY 10021, USA mengc Objective. To determine if AP is an effective , safe adjunctive treatment to standard therapy for chronic low back pain (LBP) in older patients. Methods. The inclusion criteria for subjects were: (i) LBP greater than or equal to12 weeks and (ii) age greater than or equal to60 yr; the exclusion criteria were (i) spinal tumour, infection or fracture and (ii) associated neurological symptoms. The subjects were randomized to two groups. The control group of subjects continued their usual care as directed by their physicians, i.e. NSAIDs, muscle relaxants, paracetamol and back exercises. Subjects in the AP group in addition received biweekly AP with electrical stimulation for 5 weeks. Outcome was measured by the modified Roland Disability Questionnaire (RDQ) at weeks 0, 2, 6 and 9. The primary outcome measure was change in RDQ score between weeks 0 and 6. Results Fifty-five patients were enrolled, with eight drop-outs. Twenty-four subjects were randomized to the AP group and 23 were randomized to the control group. AP subjects had a significant decrease in RDQ score of 4.1 +/- 3.9 at week 6, compared with a mean decrease of 0.7 +/- 2.8 in the control group (P = 0.001). This effect was maintained for up to 4 weeks after treatment at week 9, with a decrease in RDQ of 3.5 +/- 4.4 from baseline, compared with 0.43 +/- 2.7 in the control group (P = 0.007). The mean global transition score was higher in the AP group, 3.7 +/- 1.2, indicating greater improvement, compared with the score in the control group, 2.5 +/- 0.9 (P < 0.001). Fewer AP subjects had medication- related side-effects compared with the control group. Conclusions. AP is an effective , safe adjunctive treatment for chronic LBP in older patients. AP produces analgesic effect on an animal model of arthritis. Koo, S. T.; Lim, K. S.; Chung, K.; Chung, J. M. Society for Neuroscience Abstract Viewer and Itinerary Planner 2003, Abstract No. 66.12 Marine Biomed. Inst. and Dept. of Anat. and Neurosci., Univ. of Texas Med. Br., Galveston, TX, USA SPONSOR- Society of Neuroscience DATE- November 08-12, 2003 CONFERENCE TITLE- 33rd Annual Meeting of the Society of Neuroscience http://sfn.scholarone.com The usage of AP has gained popularity as an alternative method of treatment for certain chronic pain conditions. However, the efficacy of AP in various diseases has not been fully established and the underlying mechanism is not clearly understood. The present study investigates the efficacy and mechanism of analgesic effects of electroAP (EA) in a rat model of knee arthritis.Arthritis was induced by injecting 2% carrageenan into the knee joint of the rat. The weight- bearing force (WBF) of the affected limb during locomotion was measured before and at various times after arthritis induction, and before and at various times after EA applications. EA was applied to an acupoint (ST-36 or GB-31) on the contralateral hind limb with a train of electrical pulses at an intensity of 10 times the muscle twitch threshold for 30 minutes under halothane anesthesia.After arthritis induction, rats showed reduced WBF on the affected limb (<10% of total body weight from the normal 55% WBF), indicating a painful stepping condition. EA applied to the ST-36 point significantly improved the WBF of the arthritic limb lasting for 4 hours. However, such improvement could only be seen when arthritic impairment was mild (pre-EA WBF greater than 20% of total body weight) whereas the EA effect could not be demonstrated when arthritis was severe (pre-EA WBF less than 10%).This analgesic effect of EA in mild arthritis was blocked by intraperitoneal injection of phentolamine. EA applied to the GB-31 point, an acupoint located near ST-36, was not effective These data suggest that EA has analgesic effects on arthritic pain only when arthritis is mild. This EA- induced analgesia is mediated by an adrenergic mechanism and is produced by stimulation of a remote site in a point specific manner. Alternative methods for external cephalic version in the event of breech presentation: review of the literature Boog G. J Gynecol Obstet Biol Reprod (Paris) VOL. 33, 2004, Apr, 94-8. Service de Gynecologie-Obstetrique, CHU de Nantes, 7, quai Moncousu, 44093 Nantes Cedex 1.Fetal breech presentation at term is more and more treated by a planned cesarean section. Considering the increased maternal morbidity and mortality in relation to abdominal delivery versus vaginal birth, natural and innocuous methods have been proposed for the promotion of a spontaneous fetal cephalic version during the last two Months of pregnancy. In order to stimulate fetal motility many techniques have been described, either advising postural methods (passive bridge, Indian version, knee-chest position) or using AP (stimulation of the fifth toe and auricular points). Other techniques like chiropractic manipulations or hypnosis have also been tried. Unfortunately, most publications are retrospective and methodologically inaccurate, but it seems that their results may be favorably compared with that of the external cephalic version, a much more complex procedure, which is potentially dangerous and certainly time consuming and expensive. The only randomized controlled trial with a proven efficacy concerns moxibustion (burning herbs to stimulate the acupoint BL 67 or Zhiyin, located beside the outer corner of the fifth toenail). Cost effectiveness analysis of a randomised trial of AP for chronic headache in primary care. Wonderling D; Vickers AJ; Grieve R; McCarney R. BMJ, VOL. 328 NO. 7442, 2004, Mar 27, 747. Health Services Research Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT. David.Wonderling OBJECTIVE: To evaluate the cost effectiveness of AP in the management of chronic headache. DESIGN: Cost effectiveness analysis of a randomised controlled trial. SETTING: General practices in England and Wales. PARTICIPANTS: 401 patients with chronic headache, predominantly migraine. Interventions Patients were randomly allocated to receive up to 12 AP treatments over three months from appropriately trained physiotherapists, or to usual care alone. MAIN OUTCOME MEASURE: Incremental cost per quality adjusted life year (QALY) gained. RESULTS : Total costs during the one year period of the study were on average higher for the AP group (403 pounds sterling; 768 dollars; 598 euros) than for controls (217 pounds sterling) because of the AP practitioners' costs. The mean health gain from AP during the one year of the trial was 0.021 quality adjusted life years (QALYs), leading to a base case estimate of 9180 pounds sterling per QALY gained. This result was robust to sensitivity analysis. Cost per QALY dropped substantially when the analysis incorporated likely QALY differences for the years after the trial. CONCLUSIONS: AP for chronic headache improves health related quality of life at a small additional cost; it is relatively cost effective compared with a number of other interventions provided by the NHS. Differences of electroAP-induced analgesic effect in normal and inflammatory conditions in rats. Sekido, Reina; Ishimaru, Keisou; Sakita, Masakazu American Journal of VOL. 31, NO. 6, 2003, 955-965. Dept of Surgery, Graduate School of AP and Moxibustion, Meiji Univ of Oriental Medicine, Hiyoshi, Funai, Kyoto, 629-0392, Japan. It has been reported by Stein et al. that the immune system and peripheral opioid receptors are involved in the control of pain accompanying inflammation. ElectroAP (EA) is used to relieve various kinds of pain. However, little is known about the effect of electroAP analgesia (EAA) during hyperalgesia elicited by inflammation. The aim of the present study was to compare (1) the individual variation of EAA, (2) the durability of EAA, and (3) the effect of naloxone on EAA between normal rats and rats subjected to acute inflammatory pain. Carrageenan was subcutaneously administered by intraplantar (i.pl.) injection of the left hind paw to induce a nociceptive response. Nociceptive thresholds were measured using the paw pressure threshold (PPF). Rats received EA at 3 Hz in the left anterior tibial muscles for 1 hour after carrageenan injection. Naloxone was administered by intraperitoneal (i.p.) or i.pl. injection just before EA. EAA was elicited in 15 of 29 normal rats. These rats were divided into responders and non-responders. EAA in the responder group was almost completely antagonized by i.p. injection of naloxone. In contrast, in all the rats with carrageenan-induced inflammation, EAA was elicited, lasted for at least 24 hours after carrageenan injection, and was dose-dependently antagonized by i.pl. injection, but not significantly by i.p. injection of naloxone. It seems likely that the EAA in the rats with carrageenan-induced inflammation differs from that in normal rats, and these findings suggest that peripheral opioid receptors are involved in EAA during inflammatory conditions. Effects of acupoints TENS on heat pain threshold in normal subjects. Wang Ninghua; Hui-Chan, Christina Chinese Medical Journal (English Edition) VOL. 116, NO. 12, December, 2003, 1864-1868. Dept of Physical Medicine and Rehabilitation, First Hospital, Peking Univ, Beijing, 100034, China. Objective: To delineate the influence of transcutaneous electrical nerve stimulation ( TENS ) on heat pain threshold and vibration threshold in human. Methods: Twenty healthy, young subjects, aged from 20 to 39, participated in the study. They were randomly allocated into either TENS or placebo group. Thirty minutes of conventional TENS (200 mus pulses at 100 Hz and 2-3 times sensory threshold) or placebo stimulation was applied to the AP points (LI4) on each subject's left hand. Heat pain and vibration thresholds were measured using Medoc TSA- 2001 and VSA-3000 respectively on the thenar eminence of each subject's left hand. These assessments were done at 30, 20 and 10 minutes before and 0, 10, 20, 30, 40 and 50 minutes after 30 minutes of TENS or placebo treatment Results : This study showed a significant increase in heat pain threshold by 0.81degreec and 1.54degreeC respectively at 0 (P=0.002) and 20 minutes (P=0.004) after 30 minutes of TENS application to the LI4 acupoint of young healthy subjects, compared with placebo stimulation. Interestingly, no significant difference in vibration threshold was found between the TENS and placebo groups. Conclusion: The effect of TENS on the acupoint is to reduce pain but not tactile (specifically vibration) sensibility. Effects of AP on human cerebellum - evidence by fMRI: Deqi vs pain. Hui, K. K. S.; Liu, J.; An, H.; Napadow, V.; Kwong, K. K.; Kennedy, D. N.; Makris, N. Society for Neuroscience Abstract Viewer and Itinerary Planner 2003. Abstract No. 61. Dept. Radiology, Mass Gen. Hosp., Charlestown, MA, USA SPONSOR- Society of Neuroscience MEDIUM- e-file CONFERENCE DATE- November 08- 12, 2003 CONFERENCE TITLE- 33rd Annual Meeting of the Society of Neuroscience URL INFO- http://sfn.scholarone.com LANGUAGE- English The CNS plays an important role in the mechanisms of AP action. Many conditions with strong affective component benefit from AP treatment We first reported that AP modulated the cerebral limbic system as evidenced by fMRI and that the brain response differed markedly between deqi (a unique sensation essential to clinical efficacy ) and pain induced by AP1 The cerebellum is linked to the limbic system and participates in multiple regulatory functions including cognition and affect. Using whole brain fMRI and a new method for cerebellar parcellation2, we demonstrated that the cerebellar response correlated with that of the cerebral limbic network. This is the first report of AP effects on the cerebellum by neuroimaging. Methods: Whole brain fMRI was performed on 22 healthy adults on a 1.5T Siemens Sonata system. Functional scans were acquired by T2*- weighted gradient echo series (TE/TR 30msec/4sec. Manual AP or tactile stimulation (control) was delivered twice to ST 36, 2 min each, separated by a period with needle at rest. Data analysis employed cerebellar parcellation2 and AFNI software. Results : The cerebellum showed signal decreases with deqi and increases with pain in the dentate nucleus and multiple zones in the vermis (III, IV, VI) and hemispheres (IV, V, VI, VII, VIII). Major regions in the cerebral limbic system demonstrated similar response patterns, signal decrease in deqi and signal increase in pain. Conclusion: Cerebellar regions involved with cognition, emotion, autonomic regulation, nociception and sensorimotor functions showed distinct patterns of response to AP The cerebellum may play a concerted role with the cerebral limbic network in the modulatory actions of AP on these functions. References: 1) KKS Hui et al. Hum Brain Mapp 9:13-25, 20002) N Makris et al. J Cogn Neurosci 15:4, 1-16, 2003 Funding: NIH NCCAM. Smoking cessation with ear AP. Descriptive study on patients after a smoking cessation treatment with ear AP Ausfeld-Hafter B; Marti F; Hoffmann S. Forsch Komplementarmed Klass Naturheilkd VOL. 11, 2004, Feb, 8-13. Kollegiale Instanz fur Komplementarmedizin, Universitat Bern, Switzerland. brigitte.ausfeld BACKGROUND: In complementary medicine literature studies on long-term observation of one of its methods are rare. OBJECTIVE: The present study is an evaluation of the smoking behavior of patients treated with ear AP for smoking cessation. Additionally we investigated factors that favor or impede smoking cessation. PATIENTS AND METHODS: 249 patients who had undergone ear AP for smoking cessation between 1985 and 1998 in a practice in Aarau (Switzerland) were asked before the first treatment to fill in a form regarding their smoking behavior and retrospectively in autumn 1998 a questionnaire regarding the success of therapy Ear AP treatment consisted of 2 consultations at an interval of 10 days. The responder rate was 53.8% (134 questionnaires were returned). Finally the data of 126 persons could be evaluated. RESULTS : The Kaplan Meier analysis of the abstinence time yielded a one-year success rate of 41.1%. Men gave up smoking more easily than women. Start of smoking as well as start of treatment between the age of 20 and 40 years were favorable conditions for smoking cessation. People who had smoked 20 cigarettes or more per day before treatment profited the best. For people who smoked as a way of passing the time or because of tediousness it was easier to stop smoking than for people smoking because of nervousness. People living in a non-smoker household were able to stop smoking significantly easier than persons living in a smoker household. CONCLUSIONS: With a one- year success rate of 41.1% ear AP is a competitive alternative to orthodox medicine withdrawal methods. AP treatment can be applied and adapted individually, furthermore it is economical and without side effects ; Copyright 2004 S. Karger GmbH, Freiburg Success of AP and acupressure of the Pc 6 acupoint in the treatment of hyperemesis gravidarum. Habek D; Barbir A; Habek JC; Janculiak D; Bobi- Vukovi M. Forsch Komplementarmed Klass Naturheilkd VOL. 11, 2004, Feb, 20- 3. Clinical Hospital Osijek, Croatia. dubravko.habek OBJECTIVE: The aim of this study was to evaluate the antiemetic effect of AP (AP) and acupressure (APr) of the Pc 6 acupoint in pregnant women with hyperemesis gravidarum (HG). METHODS: A prospective, placebo-controlled trial included 36 pregnant women with HG. Two methods of AP were used: bilateral manual AP of the Pc 6 (Neiguan) acupoint (group 1, n = 10) and bilateral APr of the Pc 6 acupoint (group 2, n = 11); furthermore, superficial intracutaneous placebo AP (group 3, n = 8) and placebo APr (group 4, n = 7) was carried out. RESULTS : Anxiodepressive symptoms occurred in 9 pregnant women with HG from group 1, 8 women from group 2, 7 women from group 3, and 5 women from group 4 (p 60 0.001). The average gestation age at the occurrence of HG symptoms and the beginning of treatment was 7 weeks in group 1 and 8 weeks in groups 2, 3, and 4. Four women from group 1 and 7 women from groups 2, 3, an 4 needed intravenous compensation of liquid and electrolytes. The antiemetic metoclopramide was given intravenously to 1 woman from group 1, 2 women from group 2, 6 women from group 3, and 4 women from group 4. Promethazine was given to 1 woman from group 2, 1 woman from group 3, and to 3 women from group 4. The efficiency of the HG treatment with AP of the point Pc 6 was 90%, with APr of the Pc 6 63.6%, with placebo AP 12.5%, and with placebo APr 0%. CONCLUSION: AP (p 60 0.0001) and acupressure (p 60 0.1) are effective , nonpharmacologic methods for the treatment of HG.; Copyright 2004 S. Karger GmbH, Freiburg The central serotonergic system mediates the analgesic effect of electroAP on zusanli (ST36) acupoints. Chang FC Tsai HY; Yu MC; Yi PL; Lin JG. Journal of Biomedical Science VOL. 11, NO. 2, March-April, 2004, 179-185. jglin; AP Research Center, Institute of Chinese Medical Science, China Medical Univ, No. 91 Hsueh-Shih Road, Taichung, 404, Taiwan. Evidence in the past decade indicates that the mechanisms of anti-nociception of electroAP (EAc) involve actions of neuropeptides (i.e., enkephalin and endorphin) and monoamines (i.e., serotonin and norepinephrine) in the central nervous system. Our present results using a subcutaneous injection of formalin to test pain sensation in mice provide further understanding of the involvement of serotonin in the actions of EAc-induced analgesia. Our observations show that (1) EAc at three different frequencies (2, 10 and 100 Hz) elicited an anti- nociceptive effect as determined by behavioral observations of reduced hindpaw licking; (2) exogenously intracerebroventricular administration of 5- hydroxytryptamine (5-HT) exhibited an analgesic effect , which partially mimicked the analgesic actions of EAc; (3) the anti-nociception of EAc at different frequencies was attenuated after reduced biosynthesis of serotonin by the administration of the tryptophan hydroxylase inhibitor, p-chlorophenylalanine, and (4) the 5-HT1A and 5-HT3 receptor antagonists, pindobind-5-HT1A and LY- 278584, respectively, blocked three different frequencies of EAc-induced analgesic effects , but the anti-nociceptive effect of 100 Hz EAc was potentiated by the 5-HT2 receptor antagonist, ketanserin. These observations suggest that 5-HT1A and 5-HT3 receptors partially mediate the analgesic effects of EAc, but that the 5-HT2 receptor is conversely involved in the nociceptive response. The effect of AP on proinflammatory cytokine production in patients with chronic headache: A preliminary report. Jeong, Hyun-Ja; Hong, Seung-Heon; Nam, Yong-Che; Yang, Hee-Sook; Lyu, Yeoung-Su; Baek, Seung-Hwa; Lee, Hye- Jung; Kim, Hyung-Min American Journal of VOL. 31, NO. 6, 2003, 945-954. hmkim; Dept of Pharmacology, College of Oriental Medicine, Kyung Hee Univ, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, South Korea. AP has been widely used as a treatment for various conditions like headache and stroke, especially in Asian countries such as Korea and China. But few scientific investigations have been carried out. The aim of the present study is to investigate the effect of AP on the production of inflammatory cytokines in patients with chronic headache (CH). Patients with CH were treated with AP during the acute stage. Clinical signs of CH disappeared markedly after three months of treatment with AP Peripheral blood mononuclear cells obtained from a normal group and those from the patients with CH, before and after treatment with AP , were cultured for 24 hours in the presence or absence of lipopolysaccharide (LPS). The amount of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha) in LPS culture supernatant was significantly increased in the patients with CH compared to the healthy control group (p<0.05). But those cytokines came down toward the levels of the healthy group (p<0.05) after treatment with AP , although the levels still remained elevated. Plasma cytokine levels were analyzed to evaluate any change due to AP treatment There was little difference in the levels of IL-1beta or IL-6 due to the treatment with AP in the patients with CH, but significantly reduced plasma levels of TNF-alpha were observed. These data suggest that AP treatment has an inhibitory effect on pro-inflammatory cytokine production in patients with CH. The role of trigger point therapy in knee osteoarthritis. Yentur, E. Alp; Okcu, Guvenir; Yegul, Ibrahim. Pain Clinic VOL. 15, NO. 4, 2003, 385-390. Ayentur; Selcuk 5, Giris 5, D: 12, Mavisehir, Izmir, Turkey Background and objectives: The purpose of this study was to investigate whether injection of trigger points with lidocaine combined with intra-articular hyaluronic acid injection would be more effective in pain reduction and assisting daily activities of patients with knee osteoarthritis then hyaluronic acid injection alone. Methods: Thirty-four, female, osteoarthritis patients were randomly assigned into two groups (hyaluronic acid group, n=17; trigger point group, n=17). Patients in the trigger point group received intraarticular 2 ml Na- hyaluronate injections and trigger point injections, three times with one-week intervals. The hyaluronic acid group received only hyaluronic acid injections. Before the treatment and 7 days after the third injection, the same physician who was blind to the treatment , assessed the intensity of pain at rest or during normal daily activities, activity restrictions, and joint range of motion. Results : A significant improvement of pain and reduction of activity restrictions was observed in the trigger point group (p<0.001) while in the hyaluronic acid group, there were significant improvements only in squatting and walking (p=0.03). A significant improvement in range of movement was observed only in the trigger point group. Treating drug using prison inmates with auricular AP; A randomized controlled trial. Berman AH; Lundberg U; Krook AL; Gyllenhammar C. J Subst Abuse Treat VOL. 26, 2004, Mar, 95- 102.Dept of Psychology, Stockholm Univ, Frescati Hagvag 14, plan 3, S-106 91 Stockholm, Sweden; Center for Health Equity Studies (CHESS), Stockholm Univ/Karolinska Institutet, Sveavagen 160, plan 5, S-106 91, Stockholm, Sweden. This study tested the viability of auricular AP in prisons for alleviating inmates' symptoms of psychological and physical discomfort and reducing their drug use. The experimental NADA-Acudetox protocol was compared with a non-specific helix control protocol in a randomized trial. Over a period of 18 months, a 4-week, 14-session auricular AP treatment program was offered in two prisons to 163 men and women with self-reported drug use. Among treatment completers, no differences by method were found in self-reported symptoms of discomfort. Drug use occurred in the NADA group but not in the helix group. In contrast, confidence in the NADA treatment increased over time while it decreased for the helix treatment No significant negative side effects were observed for either method. Participants in both groups reported reduced symptoms of discomfort and improved nighttime sleep. Future research should compare auricular AP to a non-invasive control in order to attempt to disentangle active effects from placebo. >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> Best regards, Email: < WORK : Teagasc Research Management, Sandymount Ave., Dublin 4, Ireland Mobile: 353-; [in the Republic: 0] HOME : 1 Esker Lawns, Lucan, Dublin, Ireland Tel : 353-; [in the Republic: 0] WWW : http://homepage.eircom.net/~progers/searchap.htm Quote Link to comment Share on other sites More sharing options...
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